Novel enzymatic graphene oxide based biosensor for the detection of glutathione in biological body fluids

Cheraghi, Somaye; Taher, Mohammad Ali; Karimi-Maleh, Hassan; Karimi, Fatmeh; Shabani-Nooshabadi, Mehdi; Alizadeh, Marzieh; Al‐Othman, Amani; Erk, Nevin; Raman, Praveen Kumar Yegya; Karaman, Ceren

doi:10.1016/j.chemosphere.2021.132187

Cited by 173 publications

(39 citation statements)

References 40 publications

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“…In the work of Cheraghi et al, glutathione peroxidase was adsorbed to the GO surface covalently via EDC and NHS onto a glassy carbon electrode (GCE) functionalized with GO and nafion polymer. The resulting biosensor demonstrated great sensitivity to glutathione and was successfully used in real samples with acceptable data and results confirmed with statistical tests (F-test and t -test) [ 41 ].…”

Section: Graphene and Bioapplications In Biosensorsmentioning

confidence: 75%

Graphene Biosensors—A Molecular Approach

et al. 2022

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Graphene is the material elected to study molecules and monolayers at the molecular scale due to its chemical stability and electrical properties. The invention of scanning tunneling microscopy has deepened our knowledge on molecular systems through imaging at an atomic resolution, and new possibilities have been investigated at this scale. Interest on studies on biomolecules has been demonstrated due to the possibility of mimicking biological systems, providing several applications in nanomedicine: drug delivery systems, biosensors, nanostructured scaffolds, and biodevices. A breakthrough came with the synthesis of molecular systems by stepwise methods with control at the atomic/molecular level. This article presents a review on self-assembled monolayers of biomolecules on top of graphite with applications in biodevices. Special attention is given to porphyrin systems adsorbed on top of graphite that are able to anchor other biomolecules.

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Section: Graphene and Bioapplications In Biosensorsmentioning

confidence: 75%

Graphene Biosensors—A Molecular Approach

et al. 2022

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“…Tracking and quantifying biological molecules demands extremely sensitive, reliable platforms, which, at times, may not be catered for by conventional approaches. This has driven researchers to explore unique systems, such as combined carbon nanotubes of malt-extracted hydrogel [ 30 ] capable of simultaneously monitoring the various growth phases of microorganisms, graphene to recognize body fluids such as glutathione [ 31 , 32 ], and membranes inserted by nanorods [ 33 ] that aid in the detection of membrane potential. The latter setup of membrane sensing has been successfully translated to peptide-coated nanorods to detect the mean modulation response of a cell’s membrane through quantum confined Stark effect.…”

Section: Transformational Applications Of Nanomaterials For Sensing P...mentioning

confidence: 99%

Sensing beyond Senses: An Overview of Outstanding Strides in Architecting Nanopolymer-Enabled Sensors for Biomedical Applications

Malini¹,

Roy

Raj³

et al. 2022

Polymers

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Nano-enabled sensing is an expanding interdisciplinary field of emerging science with dynamic multifunctional detecting capabilities, equipped with a wide range of multi-faceted nanomaterial having diverse dimensions and composition. They have proven to be highly robust, sensitive, and useful diagnostic tools ranging from advanced industrial processes to ordinary consumer products. As no single nanomaterial has proved to be unparalleled, recent years has witnessed a large number of nanomaterial-based sensing strategies for rapid detection and quantification of processes and substances with a high degree of reliability. Nano-furnished platforms, because of easy fabrication methods and chemical versatility, can serve as ideal sensing means through different transduction mechanisms. This article, through a unified experimental-theoretical approach, uses literature of recent years to introduce, evaluate, and analyze significant developments in the area of nanotechnology-aided sensors incorporating the various classes of nanomaterial. Addressing the broad interests, the work also summarizes the sensing mechanisms using schematic illustrations, attempts to integrate the performance of different categories of nanomaterials in the design of sensors, knowledge gaps, regulatory aspects, future research directions, and challenges of implementing such techniques in standalone devices. In view of a dependency of analysis and testing on sustained growth of sensor-supported platforms, this article inspires the scientific community for more attention in this field.

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“…TiO2 nanoparticles have also been applied in wide potential windows, improving the electrode's stability, increasing the electrode response's repeatability [36,37]. Combining metallic characteristics' electronic conductivity and electroactivity with Nafion's (NFN) high ionic conductivity and ion-exchange capacity opens up many possibilities for nanoparticle design in NFN modified electrodes with unique features and uses [38]. This study employed the SPE electrodes and the promising development of a susceptible electrochemical sensor based on titanium dioxide nanoparticles and Nafion.…”

Section: Scheme 1 the Chemical Structure Of Olopatadinementioning

confidence: 99%

Construction of a simple and selective electrochemical sensor based on Nafion/TiO2 for the voltammetric determination of olopatadine

Mehmandoust

Erk

2021

J. Electrochem. Sci. Eng.

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A selective and facile voltammetric method based on titanium dioxide nanoparticles and Nafion (Nafion/TiO2 NPs) on the screen-printed electrode (SPE) was proposed for olopatadine determination. Followed by the synthesis of TiO2 nanoparticles, various methods, including high-resolution transmission electron microscopy (HR-TEM), ultraviolet-visible spectroscopy (UV-Vis), energy-dispersive X-ray (EDX) Raman spectrum, and electrochemical impedance spectroscopy (EIS) were utilized to characterize the nanomaterials. Nafion/TiO2 on the screen-printed electrode (NFN/TiO2/SPE) was used to determine olopatadine in concentration ranges of 0.01 to 0.07 and 0.07 to 14.6 µM with a limit of quantification as low as 7.0 nM, via differential pulse voltammetry technique. The NFN/TiO2/SPE offered a high-performance ability to determine olopatadine in the eye drop sample with satisfactory recovery data of 98.2–99.0 %. Also, the developed electrode showed good reproducibility, repeatability, and high selectivity features. The obtained results indicate that NFN/TiO2/SPE could be utilized as an appropriate candidate for electrochemical olopatadine sensing.

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Novel enzymatic graphene oxide based biosensor for the detection of glutathione in biological body fluids

Cited by 173 publications

References 40 publications

Graphene Biosensors—A Molecular Approach

Graphene Biosensors—A Molecular Approach

Sensing beyond Senses: An Overview of Outstanding Strides in Architecting Nanopolymer-Enabled Sensors for Biomedical Applications

Construction of a simple and selective electrochemical sensor based on Nafion/TiO2 for the voltammetric determination of olopatadine

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