Abstract:The application of small interfering (si)RNAs as potential therapeutic agents requires safe and effective methods for their delivery to the cytoplasm of the target cells and tissues. Recent studies have shown significant progress in the development of targeting reagents that facilitate the recognition of, and siRNA delivery to, specific cell types. Among recently reported delivery approaches, polymers with amphipathic properties have been used to enable endosome escape and cytosolic delivery. Here, we describe… Show more
“…The addition of NR1H3 agonists into differentiation cocktails might also be beneficial for the generation of functional hepatocyte-like cells from other stem cell resources and for further studies of hepatocyte transplantation in end-stage liver disease. Finally, it is also possible to accelerate liver regeneration in vivo by liver-specific target delivery of NR1H3 agonists, such as to package agonists into liver-specific vehicles [54,55].…”
“…The addition of NR1H3 agonists into differentiation cocktails might also be beneficial for the generation of functional hepatocyte-like cells from other stem cell resources and for further studies of hepatocyte transplantation in end-stage liver disease. Finally, it is also possible to accelerate liver regeneration in vivo by liver-specific target delivery of NR1H3 agonists, such as to package agonists into liver-specific vehicles [54,55].…”