Novel Endodontic Disinfection Approach Using Catalytic Nanoparticles

Bukhari, Sarah; Kim, Dongyeop; Liu, Yuan; Karabucak, Bekir; Koo, Hyun

doi:10.1016/j.joen.2017.12.003

Cited by 51 publications

(28 citation statements)

References 38 publications

(51 reference statements)

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“…Iron oxide nanoparticles with peroxidase‐like activities have been experimentally used as catalysts for activation of H 2 O 2 in root canal treatment. [ 266 ] Compared with conventional dental antibacterial irrigants used for disinfecting root canals, an irrigating solution comprising the nanoparticle‐H 2 O 2 assemblies is capable of killing significantly more Entercoccus faecalis , a type of bacteria that is commonly located in infected root canals that fail to heal after root canal treatment.…”

Section: Metal‐based Nanocompoundsmentioning

confidence: 99%

Metal‐Based Nanomaterials in Biomedical Applications: Antimicrobial Activity and Cytotoxicity Aspects

Makvandi

Wang

Zare

et al. 2020

Adv Funct Materials

476

368

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Microbial colonization on material surfaces is ubiquitous. Biofilms derived from surface-colonized microbes pose serious problems to the society from both an economical perspective and a health concern. Incorporation of antimicrobial nanocompounds within or on the surface of materials, or by coatings, to prevent microbial adhesion or kill the microorganisms after their attachment to biofilms, represents an important strategy in an increasingly challenging field. Over the last decade, many studies have been devoted to preparing meta-based nanomaterials that possess antibacterial, antiviral, and antifungal activities to combat pathogen-related diseases. Herein, an overview on the state-of-the-art antimicrobial nanosized metal-based compounds is provided, including metal and metal oxide nanoparticles as well as transition metal nanosheets. The antimicrobial mechanism of these nanostructures and their biomedical applications such as catheters, implants, medical delivery systems, tissue engineering, and dentistry are discussed. Their properties as well as potential caveats such as cytotoxicity, diminishing efficacy, and induction of antimicrobial resistance of materials incorporating these nanostructures are reviewed to provide a backdrop for future research.

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Section: Metal‐based Nanocompoundsmentioning

confidence: 99%

Metal‐Based Nanomaterials in Biomedical Applications: Antimicrobial Activity and Cytotoxicity Aspects

Makvandi

Wang

Zare

et al. 2020

Adv Funct Materials

476

368

View full text Add to dashboard Cite

show abstract

“…4 Despite these advances in metallurgy and design, around 10% to 50% of surfaces are not reached by these instruments. [5][6][7][8] Consequently irrigation plays a major role in the debridement of the areas not reached by mechanical conformation. 9 An ideal irrigation agent should be organic and able to dissolve necrotic tissue, bactericide, lubricant, biocompatible, nontoxic and non-caustic for periapical tissues.…”

Section: Introductionmentioning

confidence: 99%

Irrigation trends among members of the Chilean Endodontic Society

et al. 2018

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Introduction: The aim of this study is to determine the current trends of irrigation during root canal therapy by specialists who are members of the Chilean Endodontic Society. Materials and Method: A survey (Survey Monkey®-SurveyMonkey.com) was e-mailed to the 485 members of the Chilean Endodontic Society. The instrument was translated and adapted from the survey "Irrigation trends among American Association of Endodontists members: A web-based survey" applied in the USA in 2012. Participants answered a set of 16 questions that included irrigant selection, irrigant concentration, the adopted protocol, techniques or devices for irrigant activation. Results: 99% of respondents use sodium hypochlorite as the main irrigant. Data indicate that 74% of respondents use hypochlorite at a concentration of 5%. Most respondents (94%) also include EDTA in their usual practice. In addition, 90% of respondents reported that they activate the irrigating agent, and 94% confirmed that they perform a final irrigation protocol. Conclusion: The majority of respondents use sodium hypochlorite as the main irrigant at a concentration of 5%, use ethylenediaminetetraacetic acid (EDTA) as a smear removal agent, activate the irrigant, and perform a final irrigation protocol.

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“…Compared to 5.25% NaOCl, nano-MgO (5 mg/L) and chitosan NPs exhibited statistically significant long-term efficiency in the elimination of E. faecalis in the root canal system [57,58]. A previous study showed that the biomimetic iron oxide NPs with peroxidase-like activity enhanced antibacterial activity on root canal surfaces and in dentinal tubules [59].…”

Section: Antimicrobial Applications In Dentistrymentioning

confidence: 99%

Application of Antimicrobial Nanoparticles in Dentistry

2019

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Oral cavity incessantly encounters a plethora of microorganisms. Plaque biofilm—a major cause of caries, periodontitis and other dental diseases—is a complex community of bacteria or fungi that causes infection by protecting pathogenic microorganisms from external drug agents and escaping the host defense mechanisms. Antimicrobial nanoparticles are promising because of several advantages such as ultra-small sizes, large surface-area-to-mass ratio and special physical and chemical properties. To better summarize explorations of antimicrobial nanoparticles and provide directions for future studies, we present the following critical review. The keywords “nanoparticle,” “anti-infective or antibacterial or antimicrobial” and “dentistry” were retrieved from Pubmed, Scopus, Embase and Web of Science databases in the last five years. A total of 172 articles met the requirements were included and discussed in this review. The results show that superior antibacterial properties of nanoparticle biomaterials bring broad prospects in the oral field. This review presents the development, applications and underneath mechanisms of antibacterial nanoparticles in dentistry including restorative dentistry, endodontics, implantology, orthodontics, dental prostheses and periodontal field.

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Novel Endodontic Disinfection Approach Using Catalytic Nanoparticles

Abstract: The results reveal the potential to exploit nanocatalysts with enzymelike activity as a potent alternative approach for the treatment of endodontic infections.

Cited by 51 publications

References 38 publications

Metal‐Based Nanomaterials in Biomedical Applications: Antimicrobial Activity and Cytotoxicity Aspects

Metal‐Based Nanomaterials in Biomedical Applications: Antimicrobial Activity and Cytotoxicity Aspects

Irrigation trends among members of the Chilean Endodontic Society

Application of Antimicrobial Nanoparticles in Dentistry

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