Novel Electrospun Nanofibers Composed of Polyelectrolyte Complexes

Penchev, Hristo; Paneva, Dilyana; Manolova, Nevena; Rashkov, Iliya

doi:10.1002/marc.200700844

Cited by 36 publications

(34 citation statements)

References 24 publications

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“…In our previous studies we have shown that for preparation of PEC nanofibers from chitosan and strong polyacid the addition of a low-molecular-weight salt is required. 15 In the present study, when the strong polyacid PAMPS is used as a partner in the PEC TMCh/PAMPS for the preparation of a homogeneous common spinning solution the use of a 85 wt.% HCOOH solvent system and the addition of a low molecular weight salt (1.5 wt. % CaCl 2 ) were found to be appropriate.…”

Section: Preparation and Characterization Of Electrospun Nanofibers Bmentioning

confidence: 99%

Novel antibacterial electrospun materials based on polyelectrolyte complexes of a quaternized chitosan derivative

et al. 2015

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† Electronic Supplementary Information (ESI) available: UV-VIS spectra of AgNPs prepared in 85% HCOOH in the presence or absence of TMCh and digital photographs of antibacterial activity against S. aureus and E. coli of PEC nanofibrous materials with or without AgNPs. See Novel nanofibrous materials composed of polyelectrolyte complexes (PECs) between N,N,N-trimethylchitosan iodide (TMCh) and poly(acrylic acid) (PAA) or poly(2-acrylamido-2-methylpropanesulfonic acid) (PAMPS) were prepared. This was achieved by facile one-pot electrospinning of solutions of the oppositely charged polyelectrolyte partners. It was rendered possible by using solvent system containing formic acid and/or by adding a strongly ionized low-molecular-weight salt (CaCl2). Use of formic acid enabled TMCh/PAA nanofibers containing in situ synthesized silver nanoparticles (AgNPs) to be electrospun. AgNPs were with an average diameter of 3.0±0.8 nm and were uniformly distributed in the nanofibers as evidenced by the performed transmission electron microscopic (TEM) analyses. The prepared nanofibers preserved their morphology and did not dissolve in a phosphate-buffered saline (PBS). Hybrid AgNPs-containing PEC nanofibrous materials showed good antibacterial activity against Gram-positive bacteria Staphylococcus aureus and Gram-negative bacteria Escherichia coli and possessed higher efficacy than that of the nanofibers of the same composition without AgNPs and TMCh.

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Section: Preparation and Characterization Of Electrospun Nanofibers Bmentioning

confidence: 99%

Novel antibacterial electrospun materials based on polyelectrolyte complexes of a quaternized chitosan derivative

et al. 2015

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“…PECs are a type of composite fiber produced by mixing two polymers with opposite charges stabilized by strong electrostatic interactions between the polycation and polyanion. [ 7 , 14 , 15 , 16 , 17 , 18 ]. The materials based on PECs are often characterized by a degree of swelling depending on pH and external ionic concentration [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Production of Chitosan/Hyaluronan Complex Nanofibers. Characterization and Physical Properties as a Function of the Composition

et al. 2020

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In this work, optimized conditions for preparation of chitosan and hyaluronan polyelectrolyte complex are proposed. The objective was to produce new biomaterials being biocompatible and bioresorbable in the body as well as approaching the extracellular matrix (ECM) structure. These materials will be tested for chondrocyte development in tissue engineering and wound healing applications. Nanofibers made of the polyelectrolyte complex (PEC) were successfully manufactured by electrospinning, and casted films were used as a model for properties comparison. To our knowledge, it is the first time that stable chitosan/hyaluronan fibers are produced, which were observed to be long-lasting in buffer at pH~7.4. The role of thermal treatment at 120 °C for 4 h is examined to control the degree of swelling by crosslinking of the two polysaccharides by H-bonds and amide bonds formation. The properties of the materials are tested for different PEC compositions at different pH values, based on swelling and solubility degrees, diameters of nanofibers and mechanical performances. The influence of the solvent (acidic potential and composition) utilized to process biomaterials is also examined. Acid formic/water 50/50 v/v is observed to be the more appropriated solvent for the carried-out procedures.

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“…To stabilize fibrous hydrogels in aqueous media, thermal or vapor‐phase crosslinking is required which impedes their applications. Polyelectrolyte complexes have been used to improve the stability of fibrous hydrogels in aqueous solutions . A polyelectrolyte complex is formed by mixing oppositely charged polyelectrolytes such as poly(acrylic acid) (PAA) and poly(allyl amine hydrochloric acid) or PAA and chitosan (CS) in solutions with controlled polymer ratio and pH.…”

Section: Introductionmentioning

confidence: 99%

“…A polyelectrolyte complex is formed by mixing oppositely charged polyelectrolytes such as poly(acrylic acid) (PAA) and poly(allyl amine hydrochloric acid) or PAA and chitosan (CS) in solutions with controlled polymer ratio and pH. The electrostatic interactions between partially charged polymeric chains lead to the formation of a polymer hydrogel network without covalent crosslinkers . However, when exposed to solutions with high salt concentration and extreme pH, the disruption of the electrostatic interactions between polycations and polyanions results in the dissolution of the fibers.…”

Section: Introductionmentioning

confidence: 99%

Bioinspired Metal Ion Coordinated Polyelectrolyte Fibrous Nanoreactors

Malhotra

Bera

Zhai

2016

Adv Materials Inter

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improve the stability of hydrogel fibers and introduce multiple functionality to hydrogel fibers.Hydrogel fibers have similar properties to the natural macromolecules in extracellular matrix (ECM) such as large surface area, high porosity, and high content of water. They have been applied in mimicking 3D ECM [28][29][30][31][32][33][34][35][36][37] for tissue engineering, sensors, [38,39] immobilizing biocatalysts, [40] sustained releasing of proteins and drugs, [41][42][43] and wound healing. [44][45][46] Among three common ways of synthesizing fibers, self-assembly, electrospinning and phase separation, electrospinning is the most versatile, simple and cost effective technique. However, the application of electrospun hydrogel fibers (EHFs) faces challenges of low stability in aqueous solutions, liability to harsh chemical conditions and limitations in further functionalization.The EHFs of one polyelectrolyte component are water soluble, all subsequent chemical reactions have to be performed under solvent-free conditions or in non-aqueous media. To stabilize fibrous hydrogels in aqueous media, thermal or vaporphase crosslinking is required which impedes their applications. Polyelectrolyte complexes have been used to improve the stability of fibrous hydrogels in aqueous solutions. [32,[47][48][49][50][51][52][53][54] A polyelectrolyte complex is formed by mixing oppositely charged polyelectrolytes such as poly(acrylic acid) (PAA) and poly(allyl amine hydrochloric acid) or PAA and chitosan (CS) in solutions with controlled polymer ratio and pH. The electrostatic interactions between partially charged polymeric chains lead to the formation of a polymer hydrogel network without covalent crosslinkers. [47][48][49][55][56][57] However, when exposed to solutions with high salt concentration and extreme pH, the disruption of the electrostatic interactions between polycations and polyanions results in the dissolution of the fibers.Functionalizing EHFs requires a simpler and more versatile method to introduce a variety of functional materials such as nanoparticles, peptides, polymers onto the fibers for various applications. Current approaches include in situ fabrication where nanoparticles or polymers/peptides are added to polymer solutions before electrospinning, and post fabrication where nanoparticles or polymers/peptides are introduced onto fibers via reactions in solutions. Post fabrication approaches are not sufficient in obtaining uniform and controlled functionalization in large scale while the amount of nanoparticles in fibers is limited by the dispersity of nanoparticles in polymer solutions in preloading fabrication approaches. [58][59][60] Therefore, Inspired by natural metal ion/ligand interactions, stable electrospun hydrogel fibers (EHFs) are produced from polyelectrolyte complexes coordinated with various metal ions. This development provides a novel and promising approach to advance hydrogel fiber applications by creating fibers with high stability in solutions and controlled interfacial reactions. The e...

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Novel Electrospun Nanofibers Composed of Polyelectrolyte Complexes

Cited by 36 publications

References 24 publications

Novel antibacterial electrospun materials based on polyelectrolyte complexes of a quaternized chitosan derivative

Novel antibacterial electrospun materials based on polyelectrolyte complexes of a quaternized chitosan derivative

Production of Chitosan/Hyaluronan Complex Nanofibers. Characterization and Physical Properties as a Function of the Composition

Bioinspired Metal Ion Coordinated Polyelectrolyte Fibrous Nanoreactors

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