Abstract:The synthesis of
kynurenic acid derivatives with potential
biological
effect was investigated and optimized for one-batch, two-step microwave-assisted
reactions. Utilizing both chemically and biologically representative
non-, methyl-, methoxy-, and chlorosubstituted aniline derivatives,
in catalyst-free conditions, syntheses of seven kynurenic acid derivatives
were achieved in a time frame of 2–3.5 h. In place of halogenated
reaction media, tuneable green solvents were introduced for each analogue.
The potenti… Show more
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