Novel Dy2O3/ZnO-Au ternary nanocomposites: Green synthesis using pomegranate fruit extract, characterization and their photocatalytic and antibacterial properties

Khormali, Keyvan; Mizwari, Zirar M.; Ghoreishi, Seyedeh Masoumeh; Mortazavi‐Derazkola, Sobhan; Khezri, Behrooz

doi:10.1016/j.bioorg.2021.105204

Cited by 50 publications

(13 citation statements)

References 34 publications

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“…The hyperglycemia and amino acid elevation in the hemolymph appear before the onset of alterations in feeding. This observation suggests that nutrient mobilization from wasted organs in the Ras V12 ; scrib −/− tumor-bearing larvae is mainly attributed to a long-range action of the tumor rather than starvation [115,137]. Collectively, this cohort of alterations of the organ structure and the systemic metabolism defines a wasting phenotype that is also observed in cancer patients who suffer from cachexia, establishing Drosophila as a relevant model to investigate the cachexia-associated mechanism (reviewed in [139]).…”

Section: Wasting Through Systemic Induced Autophagy Is Needed For Tumor Growthmentioning

confidence: 98%

“…Ras V12 ; scrib −/− tumor-bearing larvae suffer weight loss, impaired motility and decreased feeding over time [115,137]. The energy-storing organs, such as the muscle and the fat body in the larva, progressively deteriorate over time so that many muscles shrink or rupture, and adhesion of fat body cells decreases and attains a "pearl-like" phenotype during the late stages of tumorigenesis [115,126,137]. The reduction of energy storage accompanies structural defects in these organs.…”

Section: Wasting Through Systemic Induced Autophagy Is Needed For Tumor Growthmentioning

confidence: 99%

“…In contrast, lipid storage as triacylglycerides in the fat body seems to be stable, as lipidfree cytoplasm shrinks and lipid droplet aggregation ensues [115,126]. These changes correlate with an increase of amino acid and sugar levels in the larval hemolymph (insect blood), a phenotype shared with a high-sugar diet-induced Ras V12 , csk −/− larval tumor model [115,[135][136][137][138]. The hyperglycemia and amino acid elevation in the hemolymph appear before the onset of alterations in feeding.…”

Section: Wasting Through Systemic Induced Autophagy Is Needed For Tumor Growthmentioning

confidence: 99%

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RasV12; scrib−/− Tumors: A Cooperative Oncogenesis Model Fueled by Tumor/Host Interactions

Dillard

Reis

Rusten

2021

IJMS

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The phenomenon of how oncogenes and tumor-suppressor mutations can synergize to promote tumor fitness and cancer progression can be studied in relatively simple animal model systems such as Drosophila melanogaster. Almost two decades after the landmark discovery of cooperative oncogenesis between oncogenic RasV12 and the loss of the tumor suppressor scribble in flies, this and other tumor models have provided new concepts and findings in cancer biology that has remarkable parallels and relevance to human cancer. Here we review findings using the RasV12; scrib−/− tumor model and how it has contributed to our understanding of how these initial simple genetic insults cooperate within the tumor cell to set in motion the malignant transformation program leading to tumor growth through cell growth, cell survival and proliferation, dismantling of cell–cell interactions, degradation of basement membrane and spreading to other organs. Recent findings have demonstrated that cooperativity goes beyond cell intrinsic mechanisms as the tumor interacts with the immediate cells of the microenvironment, the immune system and systemic organs to eventually facilitate malignant progression.

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Section: Wasting Through Systemic Induced Autophagy Is Needed For Tumor Growthmentioning

confidence: 98%

Section: Wasting Through Systemic Induced Autophagy Is Needed For Tumor Growthmentioning

confidence: 99%

Section: Wasting Through Systemic Induced Autophagy Is Needed For Tumor Growthmentioning

confidence: 99%

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RasV12; scrib−/− Tumors: A Cooperative Oncogenesis Model Fueled by Tumor/Host Interactions

Dillard

Reis

Rusten

2021

IJMS

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“…The use of nanotechnology is growing rapidly in many fields such as health, medicine, chemistry, food, textile and water treatment [1,2] . The properties of nanostructures are varied according to their shape, size and morphology.…”

Section: Introductionmentioning

confidence: 99%

“…The use of nanotechnology is growing rapidly in many fields such as health, medicine, chemistry, food, textile and water treatment. [1,2] The properties of nanostructures are varied according to their shape, size and morphology. Various nanostructures can be synthesized using various materials such as protein, DNA, polymer, metal, plants.…”

Section: Introductionmentioning

confidence: 99%

A Novel Biomaterial for Decolorization of Azo Dyes: Myoglobin‐Zn(II) Assisted Hybrid Nanoflowers

Altınkaynak

Turk

Yangin

et al. 2023

Chemistry & Biodiversity

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Protein‐inorganic hybrid nanoflowers are new multifunctional materials shown enhanced catalytic performance. Specially, they are used as catalyst and dye decolorizer via Fenton reaction. In this study, the Myoglobin‐Zn (II) assisted hybrid nanoflowers (MbNFs@Zn) were fabricated by using myoglobin and zinc (II) ions in different synthesis conditions. The optimum morphology was characterized SEM, TEM, EDX, XRD, and FT‐IR. The hemisphere and uniform morphology was obtained at pH 6 and 0.1 mg mL−1. The size of MbNFs@Zn are 5–6 μm. The encapsulation yield was ∼95 %. In the presence of H2O2, the peroxidase mimic activity of MbNFs@Zn was spectrophotometrically investigated in the different pH values (4–9). The highest peroxidase mimic activity was found as 3.378 EU/mg at pH 4. MbNFs@Zn was exhibited 0.28 EU/mg after eight cycles. MbNFs@Zn has lost about 92 % of its activity. The usability of MbNFs@Zn for decolorization of azo dyes such as Congo red (CR), and Evans blue (EB) was researched at different times, temperatures and concentrations. The decolorization efficiency was found maximum as 92.3 % and 88.4 % for EB and CR dyes, respectively. MbNFs@Zn has perfect properties such as enhanced catalytic performance, high decolorization efficiency, stability and reusability, and can be excellent potential materials for many industrial applications.

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Synergistic antibacterial and anticancer activity in gadolinium–chitosan nanocomposite films: A novel approach for biomedical applications

Khalil,

Bashal,

Habeeb

et al. 2024

Applied Organom Chemis

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Driven by the continuous search for materials with antibacterial and anticancer applications, this study focuses on the fabrication of nanocomposite films using chitosan as the basis material, with the addition of gadolinium oxide nanoparticles at varying weight percentages (5 and 10 wt.% Gd2O3/CS). The films were made using the coprecipitation‐solution cast approach. The structural characteristics of the Gd2O3/CS films that were formed were investigated and confirmed using a range of analytical techniques, including Fourier transform infrared, X‐ray diffraction, and scanning electron microscopy–energy‐dispersive X‐ray spectroscopy. The X‐ray diffraction study provided unambiguous evidence of an increased degree of crystallinity in chitosan with the inclusion of gadolinia. The particle size was determined using the Debye–Scherrer formula, resulting in an estimated value of 36 nm. Following this, a thorough examination was undertaken to evaluate the antibacterial effectiveness against one strain of Gram‐positive bacteria and two strains of Gram‐negative bacteria. Our research has revealed that the efficacy of the inspected Gd2O3/CS as bactericides is superior to that of CS alone. Furthermore, the MCF‐7, HCT‐116, and HepG‐2 cell lines exhibited anticancer activity when exposed to the Gd2O3/CS nanocomposites. In addition, nanocomposites exhibit significant antioxidant activity in comparison with the conventional vitamin C. These findings provide evidence for the viability of our nanocomposites in combating breast cancer.

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Novel Dy2O3/ZnO-Au ternary nanocomposites: Green synthesis using pomegranate fruit extract, characterization and their photocatalytic and antibacterial properties

Cited by 50 publications

References 34 publications

RasV12; scrib−/− Tumors: A Cooperative Oncogenesis Model Fueled by Tumor/Host Interactions

RasV12; scrib−/− Tumors: A Cooperative Oncogenesis Model Fueled by Tumor/Host Interactions

A Novel Biomaterial for Decolorization of Azo Dyes: Myoglobin‐Zn(II) Assisted Hybrid Nanoflowers

Synergistic antibacterial and anticancer activity in gadolinium–chitosan nanocomposite films: A novel approach for biomedical applications

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