Novel drying of formulated naproxen sodium using microwave radiation: Characterization and energy comparison

Al-Ali, Maha; Selvakannan, P. R.; Parthasarathy, Rajarathinam

doi:10.1016/j.powtec.2018.04.040

Cited by 9 publications

(2 citation statements)

References 24 publications

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“…The common feature of evaporation approaches is the removal of small droplets or thin layers of the solvent from different surfaces. It may lead to the crystal growth of oriented morphology as described for droplet evaporative crystallization or microwave-accelerated evaporative crystallization [38,39,40]. The crystallization of the celocoxib–PVP mixture was found to generate drug crystals of improved dissolution characteristics [41].…”

Section: Introductionmentioning

confidence: 99%

The Self-Assembly Phenomenon of Poloxamers and Its Effect on the Dissolution of a Poorly Soluble Drug from Solid Dispersions Obtained by Solvent Methods

et al. 2019

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The self-assembly phenomenon of amphiphiles has attracted particular attention in recent years due to its wide range of applications. The formation of nanoassemblies able to solubilize sparingly water-soluble drugs was found to be a strategy to solve the problem of poor solubility of active pharmaceutical ingredients. Binary and ternary solid dispersions containing Biopharmaceutics Classification System (BCS) class II drug bicalutamide and either Poloxamer®188 or Poloxamer®407 as the surface active agents were obtained by either spray drying or solvent evaporation under reduced pressure. Both processes led to morphological changes and a reduction of particle size, as confirmed by scanning electron microscopy and laser diffraction measurements. The increase in powder wettability was confirmed by means of contact angle measurements. The effect of an alteration of the crystal structure was followed by powder X-ray diffractometry while thermal properties were determined using differential scanning calorimetry. Interestingly, bicalutamide exhibited a polymorph transition after spray drying with the poloxamer and polyvinylpyrrolidone (PVP), while the poloxamer underwent partial amorphization. Moreover, due to the surface activity of the carrier, the solid dispersions formed nanoaggregates in water, as confirmed using dynamic light scattering measurements. The aggregates measuring 200–300 nm in diameter were able to solubilize bicalutamide inside the hydrophobic inner parts. The self-assembly of binary systems was found to improve the amount of dissolved bicalutamide by 4- to 8-fold in comparison to untreated drug. The improvement in drug dissolution was correlated with the solubilization of poorly soluble molecules by macromolecules, as assessed using emission spectroscopy.

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Section: Introductionmentioning

confidence: 99%

The Self-Assembly Phenomenon of Poloxamers and Its Effect on the Dissolution of a Poorly Soluble Drug from Solid Dispersions Obtained by Solvent Methods

et al. 2019

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“…Such restrictions have motivated studies into the next generation of drying technologies that can be applied to the manufacture of biotherapeutic products. Microwave drying technology has been widely used in many applications in the pharmaceutical industry such as drying, synthesis, extraction, and sterilization because of its high efficiency, low environmental impact, and energy efficiency [3,4].…”

Section: Introductionmentioning

confidence: 99%

Dynamic absorption efficiency of paracetamol powder in microwave drying

Zhai

Zhang

Wei

et al. 2019

High Temperature Materials and Processes

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In microwave drying technology, research into the dynamic absorbing properties of the powder is indispensable. In this study, the reflection loss coefficient of paracetamol powder under different temperature, water content, and thickness was calculated based on the principle of electromagnetic wave transmission. The results show that the absorption performance of powder fluctuates dynamically with a series of absorption peaks, and the position of the absorption peak shifts toward the smaller thickness direction as the water content increases or the temperature rises. Because of the influence of the powder thickness on absorbing efficiency, the powder thickness should be adjusted in real time to increase drying efficiency. This study provides the thickness range for which the absorption performance of paracetamol powder under different conditions is over 99%. This study is of great significance for understanding the drying mechanism and optimizing process parameters for microwave drying of pharmaceutical powder.

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