Novel drug targets for treatment of cryptosporidiosis

Potential Immunomodulatory Effect of Single and Combined Therapies Against Cryptosporidium Infection in Immunosuppressed Mouse Model

“…Considerable morbidity and mortality are frequently reported, specifically in immunodeficient individuals as a result of disease complications (Laurent and Lamande, 2017). Best possible therapy for cryptosporidiosis includes attention to fluids and electrolytes, antimotility agents, anti-parasitic drugs, nutritional support, and/or reversal of immunosuppression if achievable (Checkley et al, 2015;Wang et al, 2020). Effective drug treatment, particularly for infections in immunodeficient patients, has not been uni-formly successful.…”

Intestinal Parasitic Infections Among Egyptian Patients With Chronic Liver Diseases At Zagazig University Hospital

“…This Diarrhea is usually self-limiting in immunocompetents, but with lethal outcomes in immunocompromised. Being affecting the overall health of such cases, chief advances have been conveyed in screening, and early detection with precise diagnostic tools [12,36]. In this study, the main parasite detected was Cryptosporidium spp.…”

“…However, enteric protozoa as Cryptosporidium species and Giardia lamblia are the most conjoint worldwide intestinal protozoa affecting man. In developing countries cryptosporidiosis as an opportunistic infection hits mainly immunocompromised hosts having direct impact on chronic debilitating diseases, extending from causing only watery diarrhea to biliary tract affection and dysplastic changes of liver parenchyma [11,12,13]. Giardiasis causes fatty, offensive, foamy diarrhea, frequently with nausea, gurgling, bloating and weight loss resulting from fat and sugar malabsorption.…”

Proteome-wide prediction and analysis of the Cryptosporidium parvum protein–protein interaction network through integrative methods

“…Due to limited experimental progress, researches on drug targets need clues from diverse development-related pathways [68] . Several attempts have been focused on the minimalistic metabolic capacities of Cryptosporidium , aiming at suppressing parasite development.…”