Novel drug selective polystyrene membrane for simultaneous potentiometric determination of ciprofloxacin and tinidazole in pure form and pharmaceutical formulations

Sakur, Amir Alhaj; Dabbeet, Hashem A.; Noureldin, Imad

doi:10.5958/0974-360x.2020.01041.0

Cited by 3 publications

(10 citation statements)

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“…Moreover, Table 1 shows the performed preliminary studies on the influence of a plasticizer choice as it affects electrode performances. However, the results of the determinations of the SC-TPB or SC-PTA plasticized with O -NPOE were compared with those obtained in the case of DOP, and their performance characteristics were evaluated according to the IUPAC recommendations [ 23 , 24 , 25 , 26 ]. Of the two tested plasticizers, O -NPOE shows the highest total potential change.…”

Section: Resultsmentioning

confidence: 99%

“…As reported for the PVC surface membranes, the ions’ presence undergoes mobility restriction owing to their complexation with long-chain complexing agents [ 18 , 26 ]. Hence, the partition coefficients of the SC and the existence of the interfering ions between the membrane and the measured aqueous phase are the main reasons for the observed sensor selectivity.…”

Section: Resultsmentioning

confidence: 99%

“…Second, preprepared plasticized poly(vinyl chloride, PVC) membranes were coated into graphite rods and were highly sensitive, selective, reproducible, and accurate toward any of the resulting reaction mixtures of SC-TPB and/or SC-PTA in their solid states. Furthermore, O-nitrophenyl octyl ether (O-NPOE) is classically used as a plasticizer with PVC; many reports have highlighted that dioctyl phthalate (DOP) showed good results with PVC, especially if used in pencil graphite support electrodes [ 20 , 24 , 25 , 26 ]. Thus, both O-NPOE and DOP were tested in our study.…”

Section: Introductionmentioning

confidence: 99%

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Two Versatile Pencil Graphite–Polymer Sensor Electrodes Coupled with Potentiometry and Potentiometric Titration Methods: Profiling Determinations of Vitamin V in Tablets and Urine Samples

Hassan

Hamd

El-Maghrabey

et al. 2022

Sensors

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Herein, we developed a new pencil graphite ion-selective electrode strategy for the broadly used erectile dysfunction medication, sildenafil citrate (SC, vitamin V), for its automated potentiometry and potentiometric titration profiling in marketed tablets and human urine samples. The method was based on ion-pair complexation between SC and sodium tetraphenylborate (Na-TPB) or phosphotungstic acid (PTA), embedded into a pencil-fabricated graphite sensor electrode coated with poly(vinyl chloride, PVC) matrix, which is pre-plasticized with two different pre-studied plasticizers. The modern fabricated electrodes have a proven fast near-Nernstian response for SC over the concentration range of 1.0 × 10−6 to 1.0 × 10−2 and 1.0 × 10−5 to 1.0 × 10−2 M, with LODs of 6.5 × 10−7 and 5.5 × 10−6 over a pH 3–6 for (SC-TPB)- and (SC-PTA)-based membrane sensors, of O-nitrophenyl octyl ether (O-NPOE) and dioctyl phthalate (DOP), respectively. The selectivity coefficients for different interferents, including many inorganic cations, sugars, and/or nitrogenous compounds, were tested and confirmed. Applications of the proposed method were conducted on the determination of SC in its tablets and urine samples under the proper conditions. The percent recovery values were compared with those obtained by an official method and showed an RSD ≤ 0.3% (n = 5).

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Two Versatile Pencil Graphite–Polymer Sensor Electrodes Coupled with Potentiometry and Potentiometric Titration Methods: Profiling Determinations of Vitamin V in Tablets and Urine Samples

Hassan

Hamd

El-Maghrabey

et al. 2022

Sensors

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“…is promoted us to develop a new simple, sensitive, selective, rapid, and green potentiometric technique using a pencil graphite sensor for the analysis of the two drugs in their coformulated tablets. Electrochemical methods have a lot of advantages compared with the other analytical methods because of their selectivity, sensitivity, simplicity, and the wide linear range which allow the analyst to determine drugs and ions in small concentrations [22][23][24][25][26]. Among all the electrochemical techniques, pencil graphite electrodes have many features such as the small size, their fast response time, and the long lifetime [14,27] compared to those classical ion-selective electrodes [28][29][30][31].…”

Section: Introductionmentioning

confidence: 99%

“…Electrochemical methods have a lot of advantages compared with the other analytical methods because of their selectivity, sensitivity, simplicity, and the wide linear range which allow the analyst to determine drugs and ions in small concentrations [22][23][24][25][26]. Among all the electrochemical techniques, pencil graphite electrodes have many features such as the small size, their fast response time, and the long lifetime [14,27] compared to those classical ion-selective electrodes [28][29][30][31]. e main purpose of the study is to draw attention to the ability of electrochemical methods for quantitative estimation of drugs in their combination forms competitively with the other common analytical techniques used to determine combination forms such as HPLC and spectrophotometric methods, which were considered as complex, timeconsuming, and organic solvent-consuming methods.…”

Section: Introductionmentioning

confidence: 99%

Selective Consecutive Determination of Desloratadine and Montelukast Sodium in Their Pure and Binary Dosage Form Based on Pencil Graphite Electrochemical Sensors

Sakur

Nashed

Noureldin

2021

Journal of Analytical Methods in Chemistry

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In this study, we present a new, green electrochemical method for potentiometric estimation of desloratadine and montelukast sodium in their pure and binary dosage form. For that, three pencil graphite sensors were fabricated; the first one was prepared to analyse desloratadine drug (DES) by coating the graphite bar with the coating membrane, which comprises the ion pair of desloratadine and ammonium reineckate reagent (RNK), the polymer poly vinyl chloride (PVC), and the plasticizers dibutyl phthalate (DBP). The second one, which was used to analyse montelukast (MON), was constructed by using the ion pair of cadmium chloride reagent (Cd.) with montelukast and the same earlier named polymer and plasticizer. As a trial to analyse both of the drugs by the same sensor consecutively, we have constructed a combined pencil graphite electrode, which contains the two earlier suggested ion pairs, that is, we can use this electrode to selectively analyse for each drug. The proposed electrodes were effectively used for analysis of DES and MON as a single dosage form and as combined pharmaceutical preparation, without any need for prior separation that was performed depending on the difference in the efficient pH range for each sensor. The proposed sensors exhibited a Nernstian equation slopes of −30.11, 27.70, (−29.16, 29.79) mv. decade−1 in the linearity range 5.00 × 10−5−1.00 × 10−2 and 1.00 × 10−5 − 1.00 × 10−2 M, respectively. The sensors exhibit high sensitivity according to LOD values ((0.036–0.018) − (0.025-0.026) µM), respectively, and important selectivity toward the studied drugs in presence of interfering ions and excipients. The optimum circumstances were studied, and the method was validated by application of ICH rules. Finally, the method was compared with a documented method, and the required statistical values were calculated.

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Perfluorosulfonic Acid Membranes Modified with Polyaniline and Hydrothermally Treated for Potentiometric Sensor Arrays for the Analysis of Combination Drugs

et al. 2023

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A novel potentiometric multisensory system for the analysis of sulfamethoxazole and trimethoprim combination drugs was developed. The potentiometric sensors (Donnan potential (DP) was used as an analytical signal) with an inner reference solution were based on perfluorosulfonic acid (PFSA) membranes modified with polyaniline (PANI) by in situ oxidative polymerization. The order of the membrane treatment with precursor solutions and their concentrations was varied. Additionally, the PFSA/PANI composite membranes were hydrothermally treated at 120 °C. The influence of the preparation conditions and the composition of membranes on their sorption and transport properties was studied. We estimated the factors affecting the sensitivity of DP-sensors based on the PFSA/PANI composite membranes to ions of sulfamethoxazole and trimethoprim simultaneously presented in solutions. A developed multisensory system provided a simultaneous determination of two analytes in aqueous solutions without preliminary separation, derivatization, or probe treatment. The re-estimation of the calibration characteristics of the multisensory system did not show a statistically significant difference after a year of its use. The limits of detection of sulfamethoxazole and trimethoprim were 1.4 × 10−6 and 8.5 × 10−8 M, while the relative errors of their determination in the combination drug were 4 and 5% (at 5 and 6% relative standard deviation), respectively.

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Novel drug selective polystyrene membrane for simultaneous potentiometric determination of ciprofloxacin and tinidazole in pure form and pharmaceutical formulations

Cited by 3 publications

References 0 publications

Two Versatile Pencil Graphite–Polymer Sensor Electrodes Coupled with Potentiometry and Potentiometric Titration Methods: Profiling Determinations of Vitamin V in Tablets and Urine Samples

Two Versatile Pencil Graphite–Polymer Sensor Electrodes Coupled with Potentiometry and Potentiometric Titration Methods: Profiling Determinations of Vitamin V in Tablets and Urine Samples

Selective Consecutive Determination of Desloratadine and Montelukast Sodium in Their Pure and Binary Dosage Form Based on Pencil Graphite Electrochemical Sensors

Perfluorosulfonic Acid Membranes Modified with Polyaniline and Hydrothermally Treated for Potentiometric Sensor Arrays for the Analysis of Combination Drugs

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