Novel DNA methylome biomarkers associated with adalimumab response in rheumatoid arthritis patients
Ishtu Hageman,
Femke Mol,
Sadaf Atiqi
et al.
Abstract:Background and aimsRheumatoid arthritis (RA) patients are currently treated with biological agents mostly aimed at cytokine blockade, such as tumor necrosis factor-alpha (TNFα). Currently, there are no biomarkers to predict therapy response to these agents. Here, we aimed to predict response to adalimumab (ADA) treatment in RA patients using DNA methylation in peripheral blood (PBL).MethodsDNA methylation profiling on whole peripheral blood from 92 RA patients before the start of ADA treatment was determined u… Show more
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