Novel DNA methylation biomarkers for early diagnosis of oral tongue squamous cell carcinoma (OTSCC)

Alafaria, Hayat Ali Abdullah; Jalal, Areej Saud

doi:10.1007/s13353-024-00830-x

Cited by 1 publication

(1 citation statement)

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“…These may enable the modification of a patient's surveillance interval and the identification of patients with UC who require close monitoring ( 33 ). According to Alafaria and Jalal ( 103 ), MGMT may be a predictive biomarker for non-invasive oral cancer screening and early tongue squamous cell carcinoma diagnosis in the clinical setting. Nonetheless, APC gene promoter methylation, identified as a possible marker in lung cancer, may not be appropriate for screening individuals for lung cancer in general due to its low sensitivity ( 104 ).…”

Section: Roles Of Dnam In Ibdmentioning

confidence: 99%

Effects of DNA methylation and its application in inflammatory bowel disease (Review)

Akanyibah,

Zhu,

Wan

et al. 2024

Int J Mol Med

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Inflammatory bowel disease (IBD) is marked by persistent inflammation, and its development and progression are linked to environmental, genetic, immune system and gut microbial factors. DNA methylation (DNAm), as one of the protein modifications, is a crucial epigenetic process used by cells to control gene transcription. DNAm is one of the most common areas that has drawn increasing attention recently, with studies revealing that the interleukin (IL)-23/IL-12, wingless-related integration site, IL-6-associated signal transducer and activator of transcription 3, suppressor of cytokine signaling 3 and apoptosis signaling pathways are involved in DNAm and in the pathogenesis of IBD. It has emerged that DNAm-associated genes are involved in perpetuating the persistent inflammation that characterizes a number of diseases, including IBD, providing a novel therapeutic strategy for exploring their treatment. The present review discusses DNAm-associated genes in the pathogenesis of IBD and summarizes their application as possible diagnostic, prognostic and therapeutic biomarkers in IBD. This may provide a reference for the particular form of IBD and its related methylation genes, aiding in clinical decision-making and encouraging therapeutic alternatives.

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Section: Roles Of Dnam In Ibdmentioning

confidence: 99%