Novel device for male infertility screening with single-ball lens microscope and smartphone

Kobori, Yoshitomo; Pfanner, Peter; Prins, Gail S.; Niederberger, Craig S.

doi:10.1016/j.fertnstert.2016.05.027

Cited by 69 publications

(67 citation statements)

References 17 publications

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“…This enabled analysis of a semen sample with the use of a personal computer for manual counting and motility assessment. They demonstrated the use of this method correlated with the results from a computer-assisted semen analysis machine for concentration, motility and total motile count (P<0.01) (3). The use of the single-ball microscope developed by Roy et al obviates the need for a bulky, expensive conventional table microscope which some platforms require (7).…”

mentioning

confidence: 88%

Editorial on “An automated smartphone-based diagnostic assay for point-of-care semen analysis”

Vij

Agarwal

2017

Ann. Transl. Med.

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The semen analysis is the cornerstone for the diagnosis of male infertility. Manual microscopic testing and computerassisted semen analysis technology are expensive and require significant technical skill to use. Men are less likely to seek medical attention for fertility concerns than their female partners (1). Those who do seek medical attention tend to be better educated with higher status occupations (1). A delay in diagnosis of male factor infertility may prolong the infertility treatment process for the couple and result in unnecessary interventions for the female partner. A contributing factor to the hesitancy to seek medical help is the need to provide a specimen in an office setting which may cause embarrassment for some men. The idea of an 'at-home', affordable testing platform to screen for an abnormal semen analysis would obviate the need for a clinic visit and provide preliminary data to guide referrals. This might then hasten the time to treatment for any modifiable conditions causing infertility or sub-fertility. Existing modalities for "male fertility assessment" include the ® Fertile Count™ and Sperm Check ® , both of which provide an indirect measurement of sperm concentration using chemical labeling of sperm-specific proteins. These tests do not provide a quantitative assessment of the sperm concentration nor do they provide motility or velocity assessments. Furthermore, these tests have not been studied extensively for their accuracy. Su et al. described a lightweight and compact lens-free microscope for use at home or in clinics without access to a formal andrology lab (2). Testing of this model was done in a small number of semen specimens, some of which had been cryopreserved and the analysis required an experienced user which limits its applicability (2). Smartphones are an ideal platform given that they are abundant, have computing power and internet access, have high resolution cameras and accommodate several types of attachments (3). Additionally, most adults globally are quite familiar with smartphones and should be able to transmit their results directly to a provider through this modality. The use of mobile phones as a testing device in the medical realm has been applied for blood tests, bacterial detection, biomarker detection, viral detection and others (4-6). Kobori et al. describe a single-ball lens attachment for smart phones to enhance the magnification of the smart phone's built-in camera. This enabled analysis of a semen sample with the use of a personal computer for manual counting and motility assessment. They demonstrated the use of this method correlated with the results from a computer-assisted semen analysis machine for concentration, motility and total motile count (P<0.01) (3). The use of the single-ball microscope developed by Roy et al. obviates the need for a bulky, expensive conventional table microscope which some platforms require (7). This low cost attachment can be used at home if the patient has access to a computer in addition to the smartphone. Limitations...

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confidence: 88%

Editorial on “An automated smartphone-based diagnostic assay for point-of-care semen analysis”

Vij

Agarwal

2017

Ann. Transl. Med.

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“…Thus, low-cost, portable devices for quantitative sperm analysis have been developed during the last decade [28][29][30][31][32][33][34]. Optical systems using these devices in sperm motility analyses are presented in Figure 2.…”

Section: Smartphone-based Optical Systemsmentioning

confidence: 99%

“…Hence, lens-free imaging systems are preferred for low-cost, lightweight POC systems ( Figure 2A, 2B, and 2C). Comparison of optical systems for optical sperm imaging systems; (A) Lens-free holographic on-chip microscope [29], (B) 3D tracking system for human sperm [30], (C) Lens-free shadow-based CCD imaging system [31], (D) Mobile or smartphone-based clinical microscopic system to detect fluorescence from samples [28], (E) Smartphone-based optical device using diffraction patterns [32], (F) Smartphone-based sperm observation system using a single ball lens [33].…”

Section: Smartphone-based Optical Systemsmentioning

confidence: 99%

“…In 2015, Im et al developed a smartphone-based optical device that exploits diffraction patterns generated by microbeads following binding to biological targets, and detected human papillomavirus DNA. [32] To apply smartphone-based, low-cost microscopic devices, a single--ball lens of 0.8 mm diameter was purchased for less than 10 USD and was installed on a smartphone to analyse motile sperm concentrations [33]. Kobori et al correlated measurements of motility from a smartphone-based device, conventional CASA [33].…”

Section: Smartphone-based Optical Systemsmentioning

confidence: 99%

“…[32] To apply smartphone-based, low-cost microscopic devices, a single--ball lens of 0.8 mm diameter was purchased for less than 10 USD and was installed on a smartphone to analyse motile sperm concentrations [33]. Kobori et al correlated measurements of motility from a smartphone-based device, conventional CASA [33]. Moreover, the Apple iOS application iSperm uses an optical lens attachment and is commercially available for animal husbandry applications [34].…”

Section: Smartphone-based Optical Systemsmentioning

confidence: 99%

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Advances in mobile biosensors, integrating developments in materials science and instrumentation, are fueling an expansion in health data being collected and analyzed in decentralized settings. For example, semiconductor‐based sensors are enabling measurement of vital signs, and microfluidic‐based sensors are enabling measurement of biochemical markers. As biosensors for mobile health are becoming increasingly paired with smart devices, it can become critical for researchers to design biosensors—with appropriate functionalities and specifications—to work seamlessly with accompanying connected hardware and software. Here, recent research in biosensors, as well as current mobile health devices in use is described and classified into four distinct system architectures that take into account the biosensing and data processing functions required in personal mobile health devices. The path forward for integrating biosensors into smartphone‐based mobile health devices is also discussed.

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Novel device for male infertility screening with single-ball lens microscope and smartphone

Cited by 69 publications

References 17 publications

Editorial on “An automated smartphone-based diagnostic assay for point-of-care semen analysis”

Editorial on “An automated smartphone-based diagnostic assay for point-of-care semen analysis”

Recent advances in microfluidic diagnostic and treatment systems for assisted reproductive technologies in developing countries

Biosensors for Personal Mobile Health: A System Architecture Perspective

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