Novel Developments in Bacteriocins from Lactic Acid Bacteria

Nes, Ingolf F.; Gabrielsen, Christina; Brede, Dag Anders; Diep, Dzung B.

doi:10.1002/9781118868386.ch5

Cited by 15 publications

(14 citation statements)

References 144 publications

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“…Extracellular proteases or peptidases produced by bacteriocin-resistant strains can degrade bacteriocins, reducing or diminishing their antimicrobial activity (Nes et al . 2015 ). Similarly, Sedgley, Clewell and Flannagan ( 2009 ) demonstrated that gelatinase secreted by E. faecalis is responsible for the degradation and inactivation of pediocin-like bacteriocins.…”

Section: Mechanisms Of Action and Emergence Of Resistance To Bacteriomentioning

confidence: 99%

Bacteriocins as a new generation of antimicrobials: toxicity aspects and regulations

Soltani

Hammami

Cotter

et al. 2020

FEMS Microbiology Reviews

323

246

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In recent decades, bacteriocins have received substantial attention as antimicrobial compounds. Although bacteriocins have been predominantly exploited as food preservatives, they are now receiving increased attention as potential clinical antimicrobials and as possible immune-modulating agents. Infections caused by antibiotic-resistant bacteria have been declared as a global threat to public health. Bacteriocins represent a potential solution to this worldwide threat due to their broad or narrow spectrum activity against antibiotic-resistant bacteria. Notably, despite their role in food safety as natural alternatives to chemical preservatives, nisin remains the only bacteriocin legally approved by regulatory agencies as a food preservative. Moreover, insufficient data on the safety and toxicity of bacteriocins represents a barrier against the more widespread use of bacteriocins by the food and medical industry. Here we focus on the most recent trends relating to the application of bacteriocins, their toxicity and impacts.

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Section: Mechanisms Of Action and Emergence Of Resistance To Bacteriomentioning

confidence: 99%

Bacteriocins as a new generation of antimicrobials: toxicity aspects and regulations

Soltani

Hammami

Cotter

et al. 2020

FEMS Microbiology Reviews

323

246

View full text Add to dashboard Cite

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“…In particular, bacteriocins are ribosomally synthetized peptides with antimicrobial properties allowing their producer to exclude a competitor from a shared ecological niche. These compounds are frequently found in lactic acid bacteria [16,17] which are of high biotechnological interest for the food and medical industries [18]. It is therefore essential to consider the presence of bacteriocins when designing mixed microbial culture systems.…”

Section: Introductionmentioning

confidence: 99%

Invert emulsions alleviate biotic interactions in bacterial mixed culture

et al. 2023

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The large application potential of microbiomes has led to a great need for mixed culture methods. However, microbial interactions can compromise the maintenance of biodiversity during cultivation in a reactor. In particular, competition among species can lead to a strong disequilibrium in favor of the fittest microorganism. In this study, an invert emulsion system was designed by dispersing culture medium in a mixture of sunflower oil and the surfactant PGPR. Confocal laser scanning microscopy revealed that this system allowed to segregate microorganisms in independent droplets. Granulomorphometric analysis showed that the invert emulsion remains stable during at least 24 h, and that the introduction of bacteria did not have a significant impact on the structure of the invert emulsion. A two-strain antagonistic model demonstrated that this invert emulsion system allows the propagation of two strains without the exclusion of the less-fit bacterium. The monitoring of single-strain cultures of bacteria representative of a cheese microbiota revealed that all but Brevibacterium linens were able to grow. A consortium consisting of Lactococcus lactis subsp. lactis biovar diacetylactis, Streptococcus thermophilus, Leuconostoc mesenteroides, Staphylococcus xylosus, Lactiplantibacillus plantarum and Carnobacterium maltaromaticum was successfully cultivated without detectable biotic interactions. Metabarcoding analysis revealed that the system allowed a better maintenance of alpha diversity and produced a propagated bacterial consortium characterized by a structure closer to the initial state compared to non-emulsified medium. This culture system could be an important tool in the field of microbial community engineering.

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“…Therefore, in this study more detaily different properties of EMo 1-1Nik strain have been studied with the aspect of its safety or its bacteriocin activity. As it is known, bacteriocins are proteinaceous substances with inhibitory effect against more or less relative bacteria (Nes et al 2014) which were successfully used in different niches such as food (Lauková and Vlaemynck 2003), environment (Lauková et al 2002) and also animals (Pogány Simonová et al 2020), horses involving (as formerly mentioned, Lauková et al 2020Lauková et al , 2022 to optimize their health status. EMo 1-1Nik looks as a promissing candidate strain.…”

Section: Introductionmentioning

confidence: 99%

Enterococcus moraviensis EMo 1-1Nik of horse origin:characteristics and potential bacteriocin-producing strain

et al. 2023

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Nowadays, developed more precisious identi cation techniques have allowed to identify and validate newer enterococcal species. Among those species, also the species Enterococcus moraviensis was validated, the representat of which was rstly isolated from surface waters. However, in this study, characteristic and bacteriocin potential of E. moraviensis strain EMo 1-1Nik isolated from buccal mucosa of Slovak warm-blood horse breed has been studied. BLASTn analysis allotted EMo 1-1Nik strain to the species E. moraviensis with percentage identity BLASTn 16S rRNA sequence in the strain up to 100% (99.93% similarity with E. moraviensis NR113937.1 strain). The EMo 1-1Nik strain has been provided with GenBank accession number MW326085 (for nucleotide sequence SUB8683960 Seq1). EMo 1-1Nik strain is hemolysis-negative (γ -hemolysis), DNase negative and gelatinase negative; absent of virulence factor genes, low-grade bio lm-positive (0.133 ± 0.36), mostly susceptible to tested antibiotics. Moreover, 60% of EMo1-1Nik colonies were found as bacteriocin-producing against the principal indicator Enterococcus avium EA5. EMo1-1Nik concentrated substance pH 4.5 (CS) showed the inhibitory activity against EA5 strain (200 AU/mL); CSs with pH 6.3 and 7.3 reached inhibitory activity 100 AU/mL against EA5 strain.Oppositelly, EMo 1-1Nik was susceptible to Mundticin EM41/3 (800 AU/mL) produced by fecal horses strain E. mundtii EM41/3. In spite of the preliminary results, it has been shown bacteriocin potential of safe E. moraviensis EMo1-1Nik strain. The additional studies are in processing.

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Novel Developments in Bacteriocins from Lactic Acid Bacteria

Cited by 15 publications

References 144 publications

Bacteriocins as a new generation of antimicrobials: toxicity aspects and regulations

Bacteriocins as a new generation of antimicrobials: toxicity aspects and regulations

Invert emulsions alleviate biotic interactions in bacterial mixed culture

Enterococcus moraviensis EMo 1-1Nik of horse origin:characteristics and potential bacteriocin-producing strain

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