Novel design of osmotic chitosan capsules characterized by asymmetric membrane structure for in situ formation of delivery orifice

Wang, Gen Ming; Chen, Chien Ho; Ho, Hsiu O.; Wang, Sheng Shi; Sheu, Ming Thau

doi:10.1016/j.ijpharm.2006.03.041

Cited by 7 publications

(2 citation statements)

References 13 publications

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“…osmotic pressure. [26] Stability studies Based on the International Conference on Harmonization guidelines [27] the stability studies were carried out in an environmental chamber (Tempo Instruments, India). The OPT was stored at 40°C ± 2°C and 75% ±5% RH for a period of 6 months.…”

Section: Effect Of Osmotic Pressure On the Drug Releasementioning

confidence: 99%

Development of asymmetric membrane capsules of metformin hydrochloride for oral osmotic controlled drug delivery

Srinivasan¹,

Deveswaran²,

Veerbadraiah³

et al. 2014

Asian J Pharm

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A symmetric membrane capsules are one of the novel osmotic delivery devices which offer the delivery of a wide range of drugs in a controlled manner. In the present work, we developed a semi-automatic process by fabricating a hydraulic assisted mechanical robotic arm for the manufacturing of asymmetric membrane capsules and the process was validated in comparison with the manual procedure of manufacturing. The capsule walls were made by dip coating phase inversion process using cellulose acetate butyrate as polymer and propylene glycol as plasticizer/pore forming agent. The comparative examination of physical parameters in manual and semi-automatic process confirmed the consistency, reproducibility and efficiency of the semi-automatic process over manual procedure. The resulting asymmetric membrane wall was evaluated by scanning electron microscopy studies revealed the thin dense region supported on a thicker porous region. Fourier transform infrared studies showed phase inversion of the asymmetric membrane as compared to plain membrane. Osmotic release study and in vitro behavior was studied for controlled delivery of metformin hydrochloride as a model drug. In vitro release studies of the formulations showed that drug release was dependent on the concentration of pore forming agent, level of osmogents and independent of the media pH and agitation. The effect of the process variables on the drug release was optimized using 2 3 full factorial design and the release kinetics of the optimized formulation confirmed zero order kinetics with a controlled drug delivery of 13 h and the mechanism of drug release was found to be super case II transport.

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Section: Effect Of Osmotic Pressure On the Drug Releasementioning

confidence: 99%

Development of asymmetric membrane capsules of metformin hydrochloride for oral osmotic controlled drug delivery

Srinivasan¹,

Deveswaran²,

Veerbadraiah³

et al. 2014

Asian J Pharm

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“…Wang et al . [ 4 ] encapsulated the chitosan, which has poor solubility in water, to increase the efficiency of drug delivery. Chan et al [ 5 ] synthesized chitosan-g-poly(ethylene glycol) as an alternative drug delivery system with the intention that conjugation to poly(ethylene glycol) would increase the solubility of chitosan.…”

Section: Introductionmentioning

confidence: 99%

Simulation of Doxorubicin Delivery via Glucosamine(ethylene glycol) Carrier

Pirawattana

Srinophakun

2008

IJMS

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This article focuses on the molecular modeling of the release of doxorubicin from capsules composed of glucosamine(ethylene glycol) oligomers. Doxorubicin forms micelle structures with glucosamine(ethylene glycol), and the drug release mechanism can be studied through the modeling of oligomeric bond breaking under acidic, neutral, or basic conditions. Under these conditions, the activation energies were calculated to be 145.51, 135.78, and 287.60 kcal/mol, respectively, at the B3LYP/6-31G//PM3 level. Based on these values, doxorubicin can be released into acidic and neutral solutions but not into basic solution. Ethylene glycol chain length in glucosamine(ethylene glycol) also effects drug release. As the length of ethylene glycol increases, the amount of drug released increases under acidic conditions, but decreases under neutral and basic conditions. When the drug is released from glucosamine(ethylene glycol) oligomers, the drug molecule and glucosamine(ethylene glycol) molecules form a micelle structure. Studies found that, as the length of the ethylene glycol chains increases, the micelle structure is more easily formed. The ethylene glycol group can deliver doxorubicin to cancer cells in micelle form.

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Controlled Release of Drugs from Tablet Coatings

Altınkaya

2010

Pharmaceutical Sciences Encyclopedia

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Controlled‐release technology for drug delivery applications is designed to target the drug to particular places or cells in the body and to control the duration and level of the drug in the body within a specified therapeutic window. Controlled‐release dosage forms provide sustained drug release and require less frequent drug loading than conventional forms. This article presents a review of manufacturing methods for the application of coating materials on tablets, characterization methods used to evaluate tablet coatings, techniques used for manufacturing asymmetric‐type membranes, and modeling approaches employed for optimization of the tablet coating formulations.

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Novel design of osmotic chitosan capsules characterized by asymmetric membrane structure for in situ formation of delivery orifice

Cited by 7 publications

References 13 publications

Development of asymmetric membrane capsules of metformin hydrochloride for oral osmotic controlled drug delivery

Development of asymmetric membrane capsules of metformin hydrochloride for oral osmotic controlled drug delivery

Simulation of Doxorubicin Delivery via Glucosamine(ethylene glycol) Carrier

Controlled Release of Drugs from Tablet Coatings

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