Novel dental implant modifications with two-staged double benefits for preventing infection and promoting osseointegration in vivo and in vitro

Huang, Xiaoyu; Yang, Ge; Yang, Bo; Han, Qi; Zhou, Wen; Liang, Jingou; Li, Mingyun; Peng, Xian; Ren, Biao; Yang, Bangcheng; Weir, Michael D.; Guo, Qiang; Wang, Haohao; Zhou, Xinxuan; Lu, Xiong Gang; Oates, Thomas W.; Xu, Hockin H.K.; Deng, Dongmei; Zhou, Xuedong; Cheng, Lei

doi:10.1016/j.bioactmat.2021.04.041

Cited by 9 publications

(7 citation statements)

References 71 publications

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“…Accordingly, several studies try to address the anticaries effect of different chemicals on biofilm formation. A turning point in this regard was a dual strategy using microarc oxidation + poly (amidoamine)-loading dimethylaminododecyl methacrylate (PD) to combat biofilm formation that achieved promising results against peri-implantitis [ 87 , 98 ]. Prates et al stated that using protoporphyrin derivative as an antimicrobial photodynamic therapy agent exhibits 30% dental bone recovery [ 99 ].…”

Section: Animal Studies Of Chemical Materials In Oral Biofilm Treatmentsmentioning

confidence: 99%

The Current Antimicrobial and Antibiofilm Activities of Synthetic/Herbal/Biomaterials in Dental Application

Moghaddam

Ranjbar

Yazdanian

et al. 2022

BioMed Research International

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Herbal and chemical products are used for oral care and biofilm treatment and also have been reported to be controversial in the massive trials conducted in this regard. The present review is aimed at evaluating the potential of relevant herbal and chemical products and comparing their outcomes to conventional oral care products and summarizing the current state of evidence of the antibiofilm properties of different products by evaluating studies from the past eleven years. Chlorhexidine gluconate (CHX), essential oils (EOs), and acetylpyridinium chloride were, respectively, the most commonly studied agents in the included studies. As confirmed by all systematic reviews, CHX and EO significantly control the plaque formation and gingival indices. Fluoride is another interesting reagent in oral care products that has shown promising results of oral health improvement, but the evidence quality needs to be refined. The synergy between natural plants and chemical products should be targeted in the future to accede to the formation of new, efficient, and healthy anticaries strategies. Moreover, to discover their biofilm-interfering or biofilm-inhibiting activities, effective clinical trials are needed. In this review article, therapeutic applications of herbal/chemical materials in oral biofilm infections are discussed in recent years (2010-2022).

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Section: Animal Studies Of Chemical Materials In Oral Biofilm Treatmentsmentioning

confidence: 99%

The Current Antimicrobial and Antibiofilm Activities of Synthetic/Herbal/Biomaterials in Dental Application

Moghaddam

Ranjbar

Yazdanian

et al. 2022

BioMed Research International

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“…According to animal model selection guides, , the femoral condyle of New Zealand rabbits is fit to implant osseointegration evaluation. − Rabbits were fed, anesthetized, operated, and nursed as prior described, under the ethical approval by The Biomedical Ethics Committee of Medical College, Xi’an Jiaotong University (No. 2021–1564).…”

Section: Experimental Methodsmentioning

confidence: 99%

Nanoscaled Titanium Oxide Layer Provokes Quick Osseointegration on 3D-Printed Dental Implants: A Domino Effect Induced by Hydrophilic Surface

Shu,

Wang,

et al. 2023

ACS Nano

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Three-dimensional printing is a revolutionary strategy to fabricate dental implants. Especially, 3D-printed dental implants modified with nanoscaled titanium oxide layer (H-SLM) have impressively shown quick osseointegration, but the accurate mechanism remains elusive. Herein, we unmask a domino effect that the hydrophilic surface of the H-SLM facilitates blood wetting, enhances the blood shear rate, promotes blood clotting, and changes clot features for quick osseointegration. Combining computational fluid dynamic simulation and biological verification, we find a blood shear rate during blood wetting of the hydrophilic H-SLM 1.2-fold higher than that of the raw 3D-printed implant, which activates blood clot formation. Blood clots formed on the hydrophilic H-SLM demonstrate anti-inflammatory and pro-osteogenesis effects, leading to a 1.5-fold higher bone-to-implant contact and a 1.8-fold higher mechanical anchorage at the early stage of osseointegration. This mechanism deepens current knowledge between osseointegration speed and implant surface characteristics, which is instructive in surface nanoscaled modification of multiple 3D-printed intrabony implants.

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“…BacLight Live/Dead Bacterial Viability Kit (Molecular Probes; Eugene, OR, USA) was used in the study ( Huang et al., 2021 ). Live bacteria cells were stained with SYTO 9 to produce green fluorescence, and cells with compromised membranes were stained red by propidium iodide.…”

Section: Methodsmentioning

confidence: 99%

Novel dental resin infiltrant containing smart monomer dodecylmethylaminoethyl methacrylate

Huang

Liang

Zhou

et al. 2022

Front. Cell. Infect. Microbiol.

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ObjectivesWhite spot lesions (WSLs) are prevalent and often lead to aesthetic problems and progressive caries. The objectives of this study were to: (1) develop a novel resin infiltrant containing smart monomer dodecylmethylaminoethyl methacrylate (DMAEM) to inhibit WSLs, and (2) investigate the effects of DMAEM incorporation on cytotoxicity, mechanical properties, biofilm-inhibition and protection of enamel hardness for the first time.MethodsDMAEM was synthesized using 1-bromododecane, 2-methylamino ethanol and methylmethacrylate. DMAEM with mass fractions of 0%, 1.25%, 2.5% and 5% were incorporated into a resin infiltant containing BisGMA and TEGDMA. Cytotoxicity, mechanical properties and antibacterial effects were tested. After resin infiltration, bovine enamel was demineralized with saliva biofilm acids, and enamel hardness was measured.ResultDMAEM infiltration did not increase the cytotoxicity or compromise the physical properties when DMAEM mass fraction was below 5% (p > 0.05). Biofilm metabolic activity was reduced by 90%, and biofilm lactic acid production was reduced by 92%, via DMAEM (p < 0.05). Mutans streptococci biofilm CFU was reduced by 3 logs (p < 0.05). When demineralized in acid and then under biofilms, the infiltrant + 5% DMAEM group produced an enamel hardness (mean ± sd; n = 6) of 2.90 ± 0.06 GPa, much higher than 0.85 ± 0.12 GPa of the infiltrant + 0% DMAEM group (p < 0.05).SignificanceA novel resin infiltrant with excellent mechanical properties, biocompability, strong antibacterial activity and anti-demineralization effect was developed using DMAEM for the first time. The DMAEM resin infiltrant is promising for inhibiting WSLs, arresting early caries, and protecting enamel hardness.

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Novel dental implant modifications with two-staged double benefits for preventing infection and promoting osseointegration in vivo and in vitro

Cited by 9 publications

References 71 publications

The Current Antimicrobial and Antibiofilm Activities of Synthetic/Herbal/Biomaterials in Dental Application

The Current Antimicrobial and Antibiofilm Activities of Synthetic/Herbal/Biomaterials in Dental Application

Nanoscaled Titanium Oxide Layer Provokes Quick Osseointegration on 3D-Printed Dental Implants: A Domino Effect Induced by Hydrophilic Surface

Novel dental resin infiltrant containing smart monomer dodecylmethylaminoethyl methacrylate

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