Novel crosslinked thermoresponsive hydrogels with controlled poly(ethylene glycol)—poly(propylene glycol) multiblock copolymer structure

Anghelache, Alina Maria; Teodorescu, Mircea; Stănescu, Paul Octavian; Drăghici, Constantin; Vuluga, Dumitru Mircea

doi:10.1007/s00396-013-3128-1

Cited by 12 publications

(10 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Vuluga and co-workers reported the synthesis of a novel thermoresponsive crosslinked hydrogel based on different molecular weight of poly(propylene glycol)s (PPG) and diepoxy-terminated poly(ethylene glycol)s (PEG) to control the multi-block copolymer structure [64]. In an ideal situation, the hydrogel structure is expected to contain one PPG block and two PEG chains linked to the same amine group, leading to a structure with each PPG block surrounded by four PEG blocks, while each PEG block has two PPG blocks and two PEG blocks as neighbors.…”

Section: Synthetic Hydrogelsmentioning

confidence: 99%

Hydrogels for Biomedical Applications: Their Characteristics and the Mechanisms behind Them

Chai

Jiao

2017

Gels

756

452

View full text Add to dashboard Cite

Hydrogels are hydrophilic, three-dimensional networks that are able to absorb large quantities of water or biological fluids, and thus have the potential to be used as prime candidates for biosensors, drug delivery vectors, and carriers or matrices for cells in tissue engineering. In this critical review article, advantages of the hydrogels that overcome the limitations from other types of biomaterials will be discussed. Hydrogels, depending on their chemical composition, are responsive to various stimuli including heating, pH, light, and chemicals. Two swelling mechanisms will be discussed to give a detailed understanding of how the structure parameters affect swelling properties, followed by the gelation mechanism and mesh size calculation. Hydrogels prepared from natural materials such as polysaccharides and polypeptides, along with different types of synthetic hydrogels from the recent reported literature, will be discussed in detail. Finally, attention will be given to biomedical applications of different kinds of hydrogels including cell culture, self-healing, and drug delivery.

show abstract

Section: Synthetic Hydrogelsmentioning

confidence: 99%

Hydrogels for Biomedical Applications: Their Characteristics and the Mechanisms behind Them

Chai

Jiao

2017

Gels

756

452

View full text Add to dashboard Cite

show abstract

“…Results depicted comb-type grafted hydrogels with the fastest response rates [26]. In addition, the volume phase transition temperature [VPTT] of the hydrogels depended mostly on the PEG-PPG ratio [6,8]. In this study, PEG-PPG based thermoand pH sensitive comb-type grafted cationic hydrogels were successfully prepared via amine-epoxy ring opening reaction by varying PPG ratio.…”

Section: Introductionmentioning

confidence: 96%

“…Normal types of temperature sensitive PEG / PPG based hydrogels with different structure have been extensively prepared. [6,20,22,23]. However, in terms of fast response with respect to the stimuli responsiveness, one of the useful ways to improve response rates is via the adaptation of the hydrogel's structure at molecular level by grafting on the backbone of the polymers [17,18].…”

Section: Introductionmentioning

confidence: 99%

pH and thermoresponsive comb-type grafted hydrogels based on polyethylene glycol diglycidyl ether and monoamino/diamino terminated jeffamines: synthesis, characterization and physicochemical properties

Erdem

2020

Cumhuriyet Science Journal

View full text Add to dashboard Cite

In the present study, the synthesis of thermo-and pH-sensitive comb-type grafted hydrogels based on polyetheramine was performed using polyethylene glycol diglycidyl ether [PEGDGE] as the activator. Monoamino terminated Jeffamine® M2005 was used as the polyether to incorporate the hydrophobic and thermo-sensitive character in the copolymer, while diamino terminated Jeffamine® ED600 was used as the crosslinker to initiate the amineepoxy ring-opening reaction. These polyethylene glycol [PEG]-polypropylene glycol [PPG] hydrogels present pH responsive properties and thermo-sensitivity due to the presence of cationic functional groups and the Jeffamine moieties, respectively. Fourier-transform infrared (FTIR) spectroscopy and swelling behavior at different pH [2-10] and temperatures [4-50 °C] were applied to examine the physicochemical properties of the hydrogels. The volume-phase transition temperature [VPTT] of the hydrogels was determined based on PPG content and pH of the solution. The physicochemical features of the hydrogels depended on the Jeffamine used and the ratio of Jeffamine units introduced. The maximum swelling capacity of the hydrogels as a function of time was determined at 4 °C and pH 5, while the optimum deswelling capacity was obtained at 40 °C and pH 7.4. Results showed that the dual responsive PEG-PPG based hydrogels may be suitable for potential application as drug delivery system sensors.

show abstract

“…Several modification techniques have been explored in the synthesis of crosslinked polymeric organogels, which includes the wide usage of acrylic and vinylic benzene monomers via free radical polymerization 14–16 . This polymerization process is highly air‐sensitive and occurs under small‐scale atmospheric regulated conditions 17,18 . Recently, polycondensation and polyaddition polymerizing reactions have demonstrated to be suitable alternative methods for which organogels can be easily prepared 19,20 .…”

Section: Introductionmentioning

confidence: 99%

“…However, amine functionalized PPG‐based materials with good hydrophobic properties, variety, and simplicity in reaction ability as well as cost‐effectiveness, have been explored to a lesser extent in terms of use as hydrophobic absorbents for solvent recovery from wastewater. These amine functionalized materials also known as Jeffamines, have been widely reacted with epoxides, isocyanates, or aldehydes to form amide or imide bonded gel networks 18,34,35 . Nevertheless, aza‐Michael addition has demonstrated to be an effective coupling reaction alternative in reacting Jeffamines with maleimides.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of polypropylene glycol‐based novel organogels as effective materials for the recovery of organic solvents

Erdem

2020

J of Applied Polymer Sci

View full text Add to dashboard Cite

In this study, novel hydrophobic organogels were successfully prepared via the aza‐Michael addition reaction method using diamino terminated polypropylene glycol and diphenylmethane bismaleimide as monomers, in the presence of a tri‐amino functional polypropylene glycol as a crosslinking agent. The chemical structures, surface morphology, and thermal stability of the synthesized organogels were analyzed using Fourier transform infrared spectroscopy and solid‐state CPMAS 13C‐NMR, scanning electron microscope, and thermal gravimetric analysis technique, respectively. The effects of various parameters, such as the monomer ratio, amount of crosslinker, and as well as swelling properties of organogels by solvent absorption tests were studied. According to obtained results, the solvent uptake capacity increased with decreasing crosslinker ratio up to 30 wt%. The maximum solvent absorbency of the synthesized organogels were determined as 730%, 504%, 271%, 224%, 95%, and 17% for dichloromethane, tetrahydrofuran, benzene, acetone, gasoline and diesel oil, under optimum conditions, respectively. In addition, reusability of the organogels was evaluated for 10 cycles, depicting no significant loss in absorbance capacity. The fabricated organogels showed high solvent absorption efficiency with prospects as suitable material for the recovery of a wide range of organic solvents.

show abstract

Novel crosslinked thermoresponsive hydrogels with controlled poly(ethylene glycol)—poly(propylene glycol) multiblock copolymer structure

Cited by 12 publications

References 51 publications

Hydrogels for Biomedical Applications: Their Characteristics and the Mechanisms behind Them

Hydrogels for Biomedical Applications: Their Characteristics and the Mechanisms behind Them

pH and thermoresponsive comb-type grafted hydrogels based on polyethylene glycol diglycidyl ether and monoamino/diamino terminated jeffamines: synthesis, characterization and physicochemical properties

Synthesis and characterization of polypropylene glycol‐based novel organogels as effective materials for the recovery of organic solvents

Contact Info

Product

Resources

About