Novel crosslinked nanoparticles of chitosan oligosaccharide and dextran sulfate for ocular administration of dorzolamide against glaucoma

Pardeshi, Sagar R.; More, Mahesh P.; Pardeshi, Chandrakantsing V.; Chaudhari, Prashant; Gholap, Amol D.; Patil, Ankit; Patil, Pritam; Naik, Jitendra

doi:10.1016/j.jddst.2023.104719

Cited by 5 publications

(1 citation statement)

References 71 publications

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“…There have been severe deteriorations in clinical conditions caused by drug-resistant bacteria 12 – 14 . To solve these problems and improve human health, various nanotechnological methods were employed 15 .…”

Section: Introductionmentioning

confidence: 99%

Nanoengineered chitosan functionalized titanium dioxide biohybrids for bacterial infections and cancer therapy

Shabib Akhtar,

Chandrasekaran,

Saminathan

et al. 2024

Sci Rep

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Nanoengineered chitosan functionalized titanium dioxide biohybrids (CTiO2@NPs) were prepared with Amomum subulatum Roxb extract via one-pot green method and assessed by UV–Vis spectroscopy, XRD, SEM and EDAX analyses. As revealed by XRD pattern, the nanohybrids exhibits a rutile TiO2 crystallites around 45 nm in size. The emergence of the Ti–O–Ti bond is identified by observing a peak between 400 and 800 cm−1. A wide bandgap (4.8 eV) has been observed in CTiO2@NPs, due to the quantum confinement effects and the oxygen vacancies reveal the intriguing potential of developed nanohybrids for various applications. Surface flaws were identified by observing an emission band at 382, 437, 482, 517, and 556 nm. They also exhibit better antibacterial performances using well diffusion method against Staphylococcus aureus, Bacillus substilis, Klebsiella pneumonia, and Escherichia coli. CTiO2@NPs were discovered to have free radical scavenging activity on DPPH analysis and exhibit IC50 value as 95.80 μg/mL and standard (Vitamin C) IC50 is 87.62 μg/mL. CTiO2@NPs exhibited better anticancer properties against the osteosarcoma (MG-63) cell line. All these findings suggest that there is a forum for further useful therapeutic applications. Therefore, we claim that nano-engineered carbohydrated TiO2 phytohybrid is a promising solution for bacterial infections and bone cancer.

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Section: Introductionmentioning

confidence: 99%

Nanoengineered chitosan functionalized titanium dioxide biohybrids for bacterial infections and cancer therapy

Shabib Akhtar,

Chandrasekaran,

Saminathan

et al. 2024

Sci Rep

Self Cite

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Magnetic dextran-spermine nanoparticles as pH-sensitive carriers for antibiotic delivery

Abri,

Vasheghani-Farahani,

Shaki

et al. 2024

J Nanopart Res

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Advances in Polysaccharide-Based Microneedle Systems for the Treatment of Ocular Diseases

Bao,

Zhang,

Hao

et al. 2024

Nano-Micro Lett.

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The eye, a complex organ isolated from the systemic circulation, presents significant drug delivery challenges owing to its protective mechanisms, such as the blood-retinal barrier and corneal impermeability. Conventional drug administration methods often fail to sustain therapeutic levels and may compromise patient safety and compliance. Polysaccharide-based microneedles (PSMNs) have emerged as a transformative solution for ophthalmic drug delivery. However, a comprehensive review of PSMNs in ophthalmology has not been published to date. In this review, we critically examine the synergy between polysaccharide chemistry and microneedle technology for enhancing ocular drug delivery. We provide a thorough analysis of PSMNs, summarizing the design principles, fabrication processes, and challenges addressed during fabrication, including improving patient comfort and compliance. We also describe recent advances and the performance of various PSMNs in both research and clinical scenarios. Finally, we review the current regulatory frameworks and market barriers that are relevant to the clinical and commercial advancement of PSMNs and provide a final perspective on this research area.

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Novel crosslinked nanoparticles of chitosan oligosaccharide and dextran sulfate for ocular administration of dorzolamide against glaucoma

Cited by 5 publications

References 71 publications

Nanoengineered chitosan functionalized titanium dioxide biohybrids for bacterial infections and cancer therapy

Nanoengineered chitosan functionalized titanium dioxide biohybrids for bacterial infections and cancer therapy

Magnetic dextran-spermine nanoparticles as pH-sensitive carriers for antibiotic delivery

Advances in Polysaccharide-Based Microneedle Systems for the Treatment of Ocular Diseases

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