Novel coronavirus-related acute respiratory distress syndrome in a patient with twin pregnancy: A case report

Mehta, Harsh; Ivanovic, Sasa; Cronin, Aaron; VanBrunt, Lindsey; Mistry, Nirav; Miller, Richard C.; Yodice, Paul; Rezai, Fariborz

doi:10.1016/j.crwh.2020.e00220

Cited by 36 publications

(43 citation statements)

References 7 publications

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“…national average of 98.9%. 32 Notably, the only six neonates with 5 min Apgars below 7 were born very premature, 8 , 33 , 34 , 35 and even several studies including critically ill mothers reported normal Apgar scores in newborns. 29 , 31 , 36 , 37 SARS-CoV-2 in mothers does appear to be associated with a slightly higher risk of delivering preterm, but this difference seems to be driven by maternal disease severity in critically ill mothers.…”

Section: Outcomes In Newborns Born To Mothers With Positive/suspectedmentioning

confidence: 96%

“…PCR-confirmed infected newborns have been documented to show typical mild to moderate symptoms associated with SARS-CoV-2, including cough, respiratory distress, fever, and pneumonia, 36 , 40 , 41 , 42 but some newborns are asymptomatic. 8 , 35 , 39 , 43 , 44 , 45 Symptomatic newborns generally recover in one to two weeks with no subsequently reported negative health outcomes, though long-term follow-up is currently lacking. One exception is a neonate born at 30 5/7 weeks gestation to a critically ill mother who tested negative at birth, but developed pneumonia and tested positive at day of life (DOL) 7.…”

Section: Outcomes In Newborns Born To Mothers With Positive/suspectedmentioning

confidence: 99%

“…BF w/ mask Rec. no NR NR* Polónia-Valente et al, 2020 95 Portugal 5/11/20 1 0 0 0 NR NR Mild 0 Formula Yes NR DOL 3 Baergen & Heller, 2020 96 U.S. (NY) 5/12/20 21 6 4 0 NR NR Mild to moderate 0 NR NR NR NR* Taghizadieh et al., 2020 97 Iran 5/13/20 1 1 1 0 NR NR Severe NR NR NR NR NR* Kirtsman et al, 2020 62 Canada 5/14/20 1 1 1 1 3 NR Mild symptoms Recovered Moderate 0 BF with mask No NR DOL 30 Dória et al., 2020 98 Portugal 5/15/20 10 6 0 0 NR NR Asx to mild 0 NR NR NR NR* Mehta et al., 2020 35 U.S. (NJ) 5/16/20 2 2 ...…”

Section: Introductionmentioning

confidence: 99%

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A review of newborn outcomes during the COVID-19 pandemic

Kyle

Glassman

Khan

et al. 2020

Seminars in Perinatology

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As the COVID-19 pandemic continues to spread worldwide, it is crucial that we determine populations that are at-risk and develop appropriate clinical care policies to protect them. While several respiratory illnesses are known to seriously impact pregnant women and newborns, preliminary data on the novel SARS-CoV-2 Coronavirus suggest that these groups are no more at-risk than the general population. Here, we review the available literature on newborns born to infected mothers and show that newborns of mothers with positive/suspected SARS-CoV-2 infection rarely acquire the disease or show adverse clinical outcomes. With this evidence in mind, it appears that strict postnatal care policies, including separating mothers and newborns, discouraging breastfeeding, and performing early bathing, may be more likely to adversely impact newborns than they are to reduce the low risk of maternal transmission of SARS-CoV-2 or the even lower risk of severe COVID-19 disease in otherwise healthy newborns.

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Section: Outcomes In Newborns Born To Mothers With Positive/suspectedmentioning

confidence: 96%

Section: Outcomes In Newborns Born To Mothers With Positive/suspectedmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A review of newborn outcomes during the COVID-19 pandemic

Kyle

Glassman

Khan

et al. 2020

Seminars in Perinatology

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“…12 The infant was asymptomatic and there were no complications at birth. 62,63,[80][81][82][83][84][85][86][87] Negative cases 4,68,79,81,88-103 Mix-feeding 3 7 10 Positive cases [104][105][106] Negative cases 107 Not reported feeding practice 76 596 672 Positive cases 63,67, Negative cases 5,10,47,75,111,114,119,120,122, Positive cases 83,193,199,200 Mix-feeding 3 0 3 Positive cases 193,201 Not reported e feeding practice 125 2 127…”

Section: Participantsmentioning

confidence: 99%

Transmission of SARS‐CoV‐2 through breast milk and breastfeeding: a living systematic review

Centeno‐Tablante

Medina‐Rivera

Finkelstein

et al. 2020

Annals of the New York Academy of Sciences

145

123

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The pandemic of coronavirus disease 2019 (COVID-19) is caused by infection with a novel coronavirus strain, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). At present, there is limited information on potential transmission of the infection from mother to child, particularly through breast milk and breastfeeding. Here, we provide a living systematic review to capture information that might necessitate changes in the guidance on breast milk and breastfeeding given the uncertainty in this area. Our search retrieved 19,414 total records; 605 were considered for full-text eligibility and no ongoing trials were identified. Our review includes 340 records, 37 with breast milk samples and 303 without. The 37 articles with analyzed breast milk samples reported on 77 mothers who were breastfeeding their children; among them, 19 of 77 children were confirmed COVID-19 cases based on RT-PCR assays, including 14 neonates and five older infants. Nine of the 68 analyzed breast milk samples from mothers with COVID-19 were positive for SARS-CoV-2 RNA; of the exposed infants, four were positive and two were negative for COVID-19. Currently, there is no evidence of SARS-CoV-2 transmission through breast milk. Studies are needed with longer follow-up periods that collect data on infant feeding practices and on viral presence in breast milk.

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“…Viruses can exert dynamic fluctuations in the immune environment of the placenta throughout pregnancy and contribute to changes in fetal susceptibility 27 . Thus, SARS-COV-2 has also become a major concern in pregnancy, although few case reports with a small number of subjects have shown positive results in placental tissue or in newborns 14,19,21 .…”

Section: Resultsmentioning

confidence: 99%

Current evidence of SARS-CoV-2 vertical transmission: an integrative review

Oliveira

Silva

Lopes

et al. 2020

Rev. Assoc. Med. Bras.

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SUMMARY OBJECTIVE To review the current scientific evidence of vertical transmission related to coronavirus disease 2019 (COVID-19). METHODS An integrative review was performed by two independent researchers, based on the literature available in the MEDLINE (via PubMed) and LILACS databases, using the descriptors “pregnancy” AND “COVID-19” AND “vertical transmission”. This search included case reports or case series published up until 17th June 2020 in English or Portuguese. After reading the articles available in their entirety, those related specifically to the potential risks of vertical transmission of COVID-19 during pregnancy were selected. We initially found a total of 57 articles; 26 were carefully screened and 15 were finally selected. RESULTS Pregnancy can make women more susceptible to infections, especially by viral pathogens, given the various physiological and immunological changes that occur to maintain maternal-fetal balance. It is speculated that the fetus may be a possible target for COVID-19. Few studies (3 out of 15) in our analysis have found positive results for SARS-CoV-2 in fetal membranes, placenta, and in newborns right after birth. Additionally, no difference was noticed when comparing different modes of delivery, and seems reasonable to assume that pregnant women with stable clinical conditions can be encouraged for vaginal delivery. CONCLUSION Further studies with a great number of cases are warranted to elucidate whether the virus may be vertically transmitted to the fetus and if any maternal conditions can influence that. Our findings seem to demonstrate that vertical transmission is possible but quite unusual.

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Novel coronavirus-related acute respiratory distress syndrome in a patient with twin pregnancy: A case report

Cited by 36 publications

References 7 publications

A review of newborn outcomes during the COVID-19 pandemic

A review of newborn outcomes during the COVID-19 pandemic

Transmission of SARS‐CoV‐2 through breast milk and breastfeeding: a living systematic review

Current evidence of SARS-CoV-2 vertical transmission: an integrative review

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