Novel Coronavirus (COVID-19)-Associated Guillain–Barré Syndrome: Case Report

Rana, Sandeep; Lima, Arthur Azevedo; Chandra, Rahul; Valeriano, James; Desai, Troy; Freiberg, William; Small, George W.

doi:10.1097/cnd.0000000000000309

Cited by 53 publications

(59 citation statements)

References 9 publications

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“… -Arreflexia tendones profundos EEII. -Insuficiencia respiratoria (+) PCR, hisopo nasofaríngeo -Ig Favorable Rana S. EE.UU., 2020 28 RC 1 Masculino 54 años -Cuadraparesia y debilidad muscular progresiva -Arreflexia -Dificultad para orinar -Oftalmoparesia leve -Dificultad respiratoria→ Intubación (+) PCR (-) LCR -Hidroxicloroquina -Azitromicina -Ig Favorable Reyes-Bueno J.A. España, 2020 12 RC 1 Femenino 51 años -Debilidad muscular extremidades inferiores -Paraparesia -Arreflexia global -Paresia facial inferior bilateral -Disfunción autonómica (boca seca, diarrea, PA inestable) -Poliradiculoneuropatía (-) PCR (+) IgG (test ELISA) -Ig -Gabapentina Favorable Sancho-Saldaña A.…”

Section: Resultsunclassified

Relación entre COVID-19 y síndrome de Guillain-Barré en adultos. Revisión sistemática

Gittermann¹,

Feris²,

Giacoman³

2020

Neurología

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Introducción Se han reportado distintos casos de pacientes con cuadro de síndrome de Guillain-Barré asociado a COVID-19, pero falta mucha información aún sobre esta asociación y sus implicancias, el objetivo de esta revisión es analizar la evidencia disponible en esta temática en la población adulta. Material y Métodos Se realizó una revisión sistemática de estudios publicados en buscadores científicos: PubMed, Cochrane, Science Direct, Medline, OMS COVID-19. Resultados Se identificaron 45 estudios, los cuales se analizaron y completaron utilizando la plataforma Covidence, incluyendo para el análisis final 24 artículos y sumando un total de 30 pacientes. Conclusiones Se demuestra una asociación fuerte entre ambas patologías, además, los estudios analizados recalcan diferencias en la presentación de la enfermedad con mayor gravedad en los cuadros de síndrome de Guillain-Barré asociados a COVID-19.

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Section: Resultsunclassified

Relación entre COVID-19 y síndrome de Guillain-Barré en adultos. Revisión sistemática

Gittermann¹,

Feris²,

Giacoman³

2020

Neurología

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“…Some cases of polyneuropathy caused by other types of coronavirus have been published in the literature [7 , 8] and some authors support a potential neurotropic role of the virus during the active infection [9] . In the past months a substantial number of case reports of polyneuropathies consistent with GBS during or after infection by COVID-19 have been published [3 , 10 , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] (see supplementary Table 1 and all case report references in the supplementary appendix). To note, the great majority of the cases reported (86.5%) were older than 50 years with a male predominance.…”

Section: Discussionmentioning

confidence: 99%

Guillain-Barré-Strohl syndrome and COVID-19: Case report and literature review

Diez-Porras

Vergés

Gil

et al. 2020

Neuromuscular Disorders

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“…Autonomic disturbances were rarely reported (16.7%, 12/72). In cases with MFS/MFS-GBS overlap, areflexia, oculomotor disturbances, and ataxia were present in 100% (9/9), 66.7% (6/9) and 66.7% (6/9), respectively [8,19,23,30,32,33,43,44]. The median of time to nadir was calculated in 40 patients with available data and resulted 4 days (IQR 3-9) ( Table 1).…”

Section: Clinical Features Of Gbs Spectrummentioning

confidence: 99%

Guillain–Barré syndrome spectrum associated with COVID-19: an up-to-date systematic review of 73 cases

et al. 2020

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Since coronavirus disease-2019 (COVID-19) outbreak in January 2020, several pieces of evidence suggested an association between the spectrum of Guillain-Barré syndrome (GBS) and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Most findings were reported in the form of case reports or case series, whereas a comprehensive overview is still lacking. We conducted a systematic review and searched for all published cases until July 20th 2020. We included 73 patients reported in 52 publications. A broad age range was affected (mean 55, min 11-max 94 years) with male predominance (68.5%). Most patients showed respiratory and/or systemic symptoms, and developed GBS manifestations after COVID-19. However, asymptomatic cases for COVID-19 were also described. The distributions of clinical variants and electrophysiological subtypes resemble those of classic GBS, with a higher prevalence of the classic sensorimotor form and the acute inflammatory demyelinating polyneuropathy, although rare variants like Miller Fisher syndrome were also reported. Cerebrospinal fluid (CSF) albuminocytological dissociation was present in around 71% cases, and CSF SARS-CoV-2 RNA was absent in all tested cases. More than 70% of patients showed a good prognosis, mostly after treatment with intravenous immunoglobulin. Patients with less favorable outcome were associated with a significantly older age in accordance with previous findings regarding both classic GBS and COVID-19. COVID-19-associated GBS seems to share most features of classic post-infectious GBS and possibly the same immune-mediated pathogenetic mechanisms. Nevertheless, more extensive epidemiological studies are needed to clarify these issues.

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Novel Coronavirus (COVID-19)-Associated Guillain–Barré Syndrome: Case Report

Cited by 53 publications

References 9 publications

Relación entre COVID-19 y síndrome de Guillain-Barré en adultos. Revisión sistemática

Relación entre COVID-19 y síndrome de Guillain-Barré en adultos. Revisión sistemática

Guillain-Barré-Strohl syndrome and COVID-19: Case report and literature review

Guillain–Barré syndrome spectrum associated with COVID-19: an up-to-date systematic review of 73 cases

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