Novel coronavirus associated with severe respiratory disease: Case definition and public health measures

Danielsson, Niklas; Team, Ecdc Internal Response; Catchpole, Michael

doi:10.2807/ese.17.39.20282-en

Cited by 41 publications

(42 citation statements)

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“…On 16 January 2013, WHO re-published its earlier case definition for the novel coronavirus in humans along with its interim surveillance recommendations for human infection of December 2012 [20]. This has included a category for 'patient under investigation'.…”

Section: Interim Case Definitions -Case-finding Strategy and Surveillmentioning

confidence: 99%

Specific serology for emerging human coronaviruses by protein microarray

et al. 2013

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We present a serological assay for the specific detection of IgM and IgG antibodies against the emerging human coronavirus hCoV-EMC and the SARS-CoV based on protein microarray technology. The assay uses the S1 receptor-binding subunit of the spike protein of hCoV-EMC and SARS-CoV as antigens. The assay has been validated extensively using putative cross-reacting sera of patient cohorts exposed to the four common hCoVs and sera from convalescent patients infected with hCoV-EMC or SARS-CoV.

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Section: Interim Case Definitions -Case-finding Strategy and Surveillmentioning

confidence: 99%

Specific serology for emerging human coronaviruses by protein microarray

et al. 2013

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“…A recent example is the Middle East respiratory syndrome coronavirus (MERS-CoV), which emerged in 2012 in the Arabian Peninsula [3]. The consecutive importation of MERS-CoV cases to the United Kingdom (UK) [4,5], Germany [6], France [7], Italy [8], Greece [9], the Netherlands [10], United States (US) [11] and Malaysia [12] required considerable public health resources with wide public health follow-up of contacts, extensive virological testing and international risk assessments.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the surveillance system for undiagnosed serious infectious illness (USII) in intensive care units, England, 2011 to 2013

2014

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Emerging infections are a potential risk during mass gathering events due to the congregation of large numbers of international travellers. To mitigate this risk for the London 2012 Olympic and Paralympic Games, a sentinel surveillance system was developed to identify clusters of emerging infections presenting as undiagnosed serious infectious illness (USII) in intensive care units (ICUs). Following a six month pilot period, which had begun in January 2011, the surveillance was operational for a further 18 months spanning the Games. The surveillance system and reported USII cases were reviewed and evaluated after this 18 month operational period including assessment of positive predictive value (PPV), timeliness, acceptability and sensitivity of the system. Surveillance records were used to review reported cases and calculate the PPV and median reporting times of USII surveillance. Sensitivity was assessed through comparison with the pilot period. Participating clinicians completed a five-point Likert scale questionnaire about the acceptability of surveillance. Between 11 July 2011 and 10 January 2013, 34 cases were reported. Of these, 22 remained classified as USII at the time of the evaluation, none of which were still hospitalised. No clusters were identified. The 22 USII cases had no association with the Games, suggesting that they represented the background level of USII in the area covered by the surveillance. This corresponded to an annualised rate of 0.39 cases/100,000 population and a PPV of 65%. Clinicians involved in the surveillance reported high acceptability levels. The USII surveillance model could be a useful public health tool in other countries and during mass gathering events for identifying potential clusters of emerging infections.

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“…Middle East Respiratory Syndrome (MERS) is an emerging respiratory disease caused by a newly identified coronavirus the MERS coronavirus (MERS-CoV) (1)(2)(3). The outbreak has mainly remained in Saudi Arabia since 2012, with 1,106 laboratory confirmed cases to date, which have resulted in 421 deaths as of April 16, 2015 Initially, bats were considered the main reservoir (4).…”

Section: Communicated By Masayuki Saijomentioning

confidence: 99%