Novel conformation of hyaluronic acid with improved cosmetic efficacy

Abstract

Background: Hyaluronic acid presents a valuable cosmetic ingredient that occurs naturally. Its direct links to skin aging has led to its broad application. The aim of this study was to improve the cosmetic efficacy of high molecular weight hyaluronic acid (HMWHA) without chemical modifications and evaluate such improvements through clinical and in vitro studies. Methods:A novel formulation of HMWHA (SCAI-HA) was prepared and investigated to comparatively assess 6 clinical and 2 in vitro parameters concerning its dermatological cosmetic efficacy and biological properties. The dermatological and cellular parameters examined in this study include skin hydration, transepidermal water loss (TEWL), skin elasticity, wrinkles, facial sagging, dermal density, cytotoxicity, and collagen synthesis.Results: SCAI-HA exhibited the ability to improve the tested dermatological parameters (hydration, elasticity, wrinkles, and density) to magnitudes comparable to those of HMWHA. In addition, SCAI-HA showed notably improved capacities for attenuating facial sagging and TEWL and promoting cellular collagen synthesis in normal human dermal fibroblasts. Conclusion:SCAI-HA presents a novel conformation of HMWHA with improved cosmetic efficacy in mitigating (i) facial sagging, (ii) TEWL, and promoting, and (iii) collagen synthesis. These findings denote the enhancement of SCAI-HA as a cosmetic ingredient with potential anti-aging properties.

3D printed scaffolds based on hyaluronic acid bioinks for tissue engineering: a review

“…Injectable-grade HA produced by microbial fermentation can be crosslinked using a chemical crosslinking agent, such as 1,4-butanediol diglycerol ether, to form a stable 3D network. The crosslinks are irreversible bonds and thus are considered “permanent.” These biological materials are used to develop cosmetic products, such as volumetric dermal fillers, through a series of processes, including purification and sterilization, to obtain granulated crosslinked HA gels [ 105 , 106 ]. Wang et al [ 69 ] synthesized HAMA by grafting methacrylic anhydride onto the HA backbone.…”