Novel conditioning regimens for bone marrow transplantation

Abstract

Bone marrow transplantation (BMT) has evolved into an effective strategy for the treatment of hematological and oncological disorders. Radiotherapy and chemotherapy are used as conditioning regimens prior to BMT to suppress host immunity and reduce tumor burden. High doses of total body irradiation are conventionally administered along with alkylating agents, ie, the myeloablative regimen, to help ensure rapid engraftment of donor cells and to prevent relapse. However, the toxicity of the myeloablative conditioning regimen and unacceptable nonrelapse mortality rules out this approach for older patients by whom less intense preparative regimens are likely to be better tolerated. The reduced-intensity and nonmyeloablative conditioning regimens have been demonstrated by many investigators to be novel approaches resulting in a lower nonrelapse mortality rate and lower incidence of severe acute graft versus host disease. Here, we review the conditioning regimens employed as a pretreatment for BMT, and focus on the novel conditioning regimens and cutting edge developments.

Autologous hematopoietic stem cell transplantation conditioning regimens and chimeric antigen receptor T cell therapy in various diseases

“…To eliminate the damaged cells in the body, HSCT conditioning requires chemotherapy and/or radiation, but this procedure can have life-threatening side effects. Therefore, HSCT is primarily used to treat malignant illnesses where its advantages outweigh its potentially deadly hazards[ 9 ]. As an alternative to the traditional conditioning regimen, a reduced-intensity and non-myeloablative con ditioning regimen has been presented[ 10 ].…”