Novel Concepts About the Role of Lectins in the Plant Cell

Dammes, Els J. M. Van; Fouquaert, Elke; Lannoo, Nausicaä; Vandenborre, Gianni; Schouppe, Dieter; Peumans, Willy J.

doi:10.1007/978-1-4419-7877-6_13

Cited by 26 publications

(23 citation statements)

References 119 publications

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“…Plants express a huge number of highly diverse lectins, exhibiting different molecular structures and binding specificities toward endogenous (plant) glycans as well as to glycans from exogenous (non-plant) origin (Van Damme et al, 2008, 2011). …”

Section: Pathogen Recognition Based On Protein–carbohydrate Interactionsmentioning

confidence: 99%

Lectin domains at the frontiers of plant defense

2014

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Plants are under constant attack from pathogens and herbivorous insects. To protect and defend themselves, plants evolved a multi-layered surveillance system, known as the innate immune system. Plants sense their encounters upon perception of conserved microbial structures and damage-associated patterns using cell-surface and intracellular immune receptors. Plant lectins and proteins with one or more lectin domains represent a major part of these receptors. The whole group of plant lectins comprises an elaborate collection of proteins capable of recognizing and interacting with specific carbohydrate structures, either originating from the invading organisms or from damaged plant cell wall structures. Due to the vast diversity in protein structures, carbohydrate recognition domains and glycan binding specificities, plant lectins constitute a very diverse protein superfamily. In the last decade, new types of nucleocytoplasmic plant lectins have been identified and characterized, in particular lectins expressed inside the nucleus and the cytoplasm of plant cells often as part of a specific plant response upon exposure to different stress factors or changing environmental conditions. In this review, we provide an overview on plant lectin motifs used in the constant battle against pathogens and predators during plant defenses.

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Section: Pathogen Recognition Based On Protein–carbohydrate Interactionsmentioning

confidence: 99%

Lectin domains at the frontiers of plant defense

2014

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“…The endogenous function of ricin within the plant remains elusive; based on the cytotoxic activity it is speculated that it might function in the defense against all sorts of plant-eating or -damaging organisms [98,99,100,101]. …”

Section: Ricin a Toxic Lectin From Ricinus Communismentioning

confidence: 99%

Ricinus communis Intoxications in Human and Veterinary Medicine—A Summary of Real Cases

Worbs

Köhler

Pauly

et al. 2011

Toxins

192

177

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Accidental and intended Ricinus communis intoxications in humans and animals have been known for centuries but the causative agent remained elusive until 1888 when Stillmark attributed the toxicity to the lectin ricin. Ricinus communis is grown worldwide on an industrial scale for the production of castor oil. As by-product in castor oil production ricin is mass produced above 1 million tons per year. On the basis of its availability, toxicity, ease of preparation and the current lack of medical countermeasures, ricin has gained attention as potential biological warfare agent. The seeds also contain the less toxic, but highly homologous Ricinus communis agglutinin and the alkaloid ricinine, and especially the latter can be used to track intoxications. After oil extraction and detoxification, the defatted press cake is used as organic fertilizer and as low-value feed. In this context there have been sporadic reports from different countries describing animal intoxications after uptake of obviously insufficiently detoxified fertilizer. Observations in Germany over several years, however, have led us to speculate that the detoxification process is not always performed thoroughly and controlled, calling for international regulations which clearly state a ricin threshold in fertilizer. In this review we summarize knowledge on intended and unintended poisoning with ricin or castor seeds both in humans and animals, with a particular emphasis on intoxications due to improperly detoxified castor bean meal and forensic analysis.

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“…The complex also contains eight genes annotated as Curculin-like (mannose-binding) lectin (IPR001480). Lectin synthesis has been observed to occur in plants in response to specific environmental stresses and lectins are involved in stress signaling (Van Damme et al, 2004 ; Lannoo and Van Damme, 2010 ; Van Dammes et al, 2011 ) and in plant symbiosis development (De Hoff et al, 2009 ).…”

Section: Resultsmentioning

confidence: 99%

“…In addition, terpenoids have been linked to interactions with plant roots and root morphology (Umehara et al, 2008 ). N-linked glycans (N-Glycan Biosynthesis, map00510) play an important role in cell-cell interaction (Van Damme et al, 2004 ; Lannoo and Van Damme, 2010 ; Van Dammes et al, 2011 ) and N-linked glycans are potentially associated with the sugar-binding lectins in sensor protein complex A. The Biosynthesis of Phenylpropanoids (map01061) includes compounds such as catechin, epicatechin, and 4-hydroxybenzoate 4-OP-glucoside which have been identified as crucial in plant-fungal interactions, particularly for early mycorrhization (Campbell and Ellis, 1992 ; Weiss et al, 1997 ).…”

Section: Resultsmentioning

confidence: 99%

Multi-Omics Approach Identifies Molecular Mechanisms of Plant-Fungus Mycorrhizal Interaction

et al. 2016

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In mycorrhizal symbiosis, plant roots form close, mutually beneficial interactions with soil fungi. Before this mycorrhizal interaction can be established however, plant roots must be capable of detecting potential beneficial fungal partners and initiating the gene expression patterns necessary to begin symbiosis. To predict a plant root—mycorrhizal fungi sensor systems, we analyzed in vitro experiments of Populus tremuloides (aspen tree) and Laccaria bicolor (mycorrhizal fungi) interaction and leveraged over 200 previously published transcriptomic experimental data sets, 159 experimentally validated plant transcription factor binding motifs, and more than 120-thousand experimentally validated protein-protein interactions to generate models of pre-mycorrhizal sensor systems in aspen root. These sensor mechanisms link extracellular signaling molecules with gene regulation through a network comprised of membrane receptors, signal cascade proteins, transcription factors, and transcription factor biding DNA motifs. Modeling predicted four pre-mycorrhizal sensor complexes in aspen that interact with 15 transcription factors to regulate the expression of 1184 genes in response to extracellular signals synthesized by Laccaria. Predicted extracellular signaling molecules include common signaling molecules such as phenylpropanoids, salicylate, and jasmonic acid. This multi-omic computational modeling approach for predicting the complex sensory networks yielded specific, testable biological hypotheses for mycorrhizal interaction signaling compounds, sensor complexes, and mechanisms of gene regulation.

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Novel Concepts About the Role of Lectins in the Plant Cell

Cited by 26 publications

References 119 publications

Lectin domains at the frontiers of plant defense

Lectin domains at the frontiers of plant defense

Ricinus communis Intoxications in Human and Veterinary Medicine—A Summary of Real Cases

Multi-Omics Approach Identifies Molecular Mechanisms of Plant-Fungus Mycorrhizal Interaction

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