Novel concept of the smart NIR-light–controlled drug release of black phosphorus nanostructure for cancer therapy

Qiu, Meng; Wang, Dou; Liang, Weiyuan; Liu, Liping; Zhang, Yin; Chen, Xing; Sang, David K.; Xing, Chenyang; Li, Zhongjun; Dong, Biqin; Feng, Xiqi; Fan, Dianyuan; Bao, Shaowen; Zhang, Han; Cao, Yihai

doi:10.1073/pnas.1714421115

Cited by 678 publications

(416 citation statements)

References 55 publications

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“…In recent years, a new type of 2D single‐element material has been successfully prepared and widely used in the field of photodetectors due to its graphene‐like electronic structure and excellent optical and electronic properties. BP is currently the most popular single‐element 2D material with an adjustable direct bandgap . When the thickness of the bulk BP is reduced to a single layer, its bandgap is increased from 0.3 to 2.0 eV .…”

Section: Pec‐type Photodetectors Based On 2d Materialsmentioning

confidence: 99%

Self‐Powered Photodetectors Based on 2D Materials

Qiao

Huang

Ren

et al. 2019

Advanced Optical Materials

Self Cite

257

216

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Self‐powered photodetectors are considered as a new type of photodetectors enabling self‐powered photodetection without external power. The excellent photoresponsivity, fast photoresponse rate, low dark current, and large light on/off ratio of these photodetectors have attracted wide interest among scholars. 2D materials are widely used in self‐powered photodetectors due to their excellent optical and electrical properties, unique 2D structures, and their capabilities to exhibit excellent photodetection performance. According to the self‐driving mechanism of 2D material‐based self‐powered photodetectors, they are divided into three categories: p–n junction photodetectors, Schottky junction photodetectors, and photoelectrochemical photodetectors. From these three perspectives, the research progress of 2D material‐based self‐powered photodetectors is summarized in detail here. Research reports indicate that 2D material‐based self‐powered photodetectors have excellent self‐powered photoresponse behavior, good light on/off characteristics, and wideband spectral response ranges. The excellent photoresponse performance of 2D material‐based self‐powered photodetectors facilitates their potential applications in the field of optoelectronic devices. In particular, self‐powered photodetectors have great potential as novel emerging self‐driven optoelectronic devices. Finally, directions for the further development of 2D material‐based self‐powered photodetectors are anticipated.

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Section: Pec‐type Photodetectors Based On 2d Materialsmentioning

confidence: 99%

Self‐Powered Photodetectors Based on 2D Materials

Qiao

Huang

Ren

et al. 2019

Advanced Optical Materials

Self Cite

257

216

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“…In recent years, nanocarriers have been intensively investigated for cancer therapeutics . To date, many mechanisms have been proposed to regulate the time, rate and location of the drugs . Recently, we developed a free‐blockage controlled release system by integrating water channel with mesoporous nanocarriers, which realized controlled releasing chemotherapeutic agents in tumor cells .…”

Section: Methodsmentioning

confidence: 99%

Dual Stimuli‐Responsive Controlled Release Nanocarrier for Multidrug Resistance Cancer Therapy

Jiao

Wang

et al. 2019

ChemPhysChem

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Multidrug resistance of cancer cells is a major obstacle for cancer chemotherapy. Herein, we present a nanocarrier that can release chemotherapeutic agents to induce tumor cell death and generate NO under NIR to overcome multidrug resistance in cancer chemotherapy. Owing to the unique structure of the water channel in this controlled release system for chemotherapeutic agents, the nanocarrier surface is equipped with more active sites to graft NO donor molecules. The released NO performs very well in reversing multidrug resistance by inhibiting P‐gp expression. Our findings provide new insight into multidrug resistance cancer therapy and controlled release nanocarriers for multiple drugs.

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“…[112] The CarHC domains tetramerize when binding to adenosylco balamin (AdoB12) in the dark and can readily dissociate into monomers accompanied with a drastic protein conformational change caused by the cleavage of the CCo bond on exposure to green (522 nm) or white light. [113] Copyright 2012, American Chemical Society. Mater.…”

Section: Controlled Drug Releasementioning

confidence: 99%

“…[113] NIRinduced (808 nm) heating due to the photothermal con version of BP results in hydrolysis and subsequent melting of the hydrogel, which triggers the controlled release of encap sulated doxorubicin (DOX) ( Figure 3A). Cao and co workers developed an NIRlightcontrolled drug delivery plat form based on the composite hydrogels of lowmeltingpoint agarose and PEGylated black phosphorous (BP) nanosheets.…”

Section: Controlled Drug Releasementioning

confidence: 99%

Design and Applications of Photoresponsive Hydrogels

2019

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materials with diverse applications in var ious fields due to their tunable chemistry structure and physical properties as well as excellent biocompatibility. [2][3][4][5] Hydrogel research has evolved from static mate rials to smart ones, whose structures and property show responsiveness to external stimuli, including temperature, pH, light, electric or magnetic fields, and the pres ence of enzymes or ion concentrations. [6][7][8][9][10][11] This unprecedented level of control over material properties has driven both med ical and industrial fields into the realm of possibility: controlled drug delivery, [12] chemical sensors, [13] soft actuators or robotics, [14][15][16] or scaffolds for dynamic 3D cell culture. [17] Photoresponsiveness is attractive due to the inherent advan tages of light as stimulus. Light is non invasive and allows remote manipulation of materials without requiring additional reagents, thus, with limited byproducts. Modulation of irradiation parameters, such as light intensity and irradiation time, permits the pre cise control of irradiation dosage, thereby, the degree of photo reactions. Spatial control can be achieved in both 2D and 3D, and temporal control is possible by simply turning the respec tive light source on or off. Wavelengthselective photo chemical reactions can be used for orthogonal photomediation of hydrogel properties. [18] Photoresponsive hydrogels, as externally tunable materials, strongly contribute to the field of soft smart materials in regard to the abovementioned applications. [19] In this review, we elaborate on the design and the emerging appli cations of photoresponsive hydrogels. A comprehensive review about utilizing light for the formation of hydrogels is given by Mi and coworkers. [20] First, we discuss responsive modes and photochemical mechanisms of photoresponsive hydrogels. Fol lowing this, we highlight their applications for dynamic cell environments, smart biointerfaces, controlled drug delivery, photodriven actuators, and lighthealing materials. The review concludes with an outlook on the challenges and potential future approaches for photo responsive hydrogels. Light as Stimulus for Hydrogels Macroscopic Hydrogel PhotoresponsesThe interaction of light with photoresponsive hydrogels can result in different responses, some of which are observable with the bare eye. Those include hydrogel formation or degradation, network contraction or expansion, and chemical modifications in the network, which then have an immediate consequence on Hydrogels are the most relevant biochemical scaffold due to their tunable properties, inherent biocompatibility, and similarity with tissue and cell environments. Over the past decade, hydrogels have developed from static materials to "smart" responsive materials adapting to various stimuli, such as pH, temperature, chemical, electrical, or light. Light stimulation is particularly interesting for many applications because of the capability of contact-free remote manipulation of biomaterial properties and inherent spatial and t...

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Novel concept of the smart NIR-light–controlled drug release of black phosphorus nanostructure for cancer therapy

Cited by 678 publications

References 55 publications

Self‐Powered Photodetectors Based on 2D Materials

Self‐Powered Photodetectors Based on 2D Materials

Dual Stimuli‐Responsive Controlled Release Nanocarrier for Multidrug Resistance Cancer Therapy

Design and Applications of Photoresponsive Hydrogels

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