“…Substantial previous literature studies have reported that 3,3′-DIM compounds exhibit immense pharmacological properties such as anti-bacterial, anti-fungal, and anti-proliferative. 8,34,35 This major component 3,3′-DIM is obtained from Brassica cruciferous plants such as cabbage, broccoli, brussels sprouts, cauliflower, etc. Roy's group, 10 for the first time in Leishmania parasites, reported that 3,3′-DIM acts as a potent topoisomerase I poison and induces programmed cell death by inhibiting the mitochondrial H + -ATP synthase.…”