Novel composite cement containing the anti-microbial compound CPC-Montmorillonite

Yamamoto, Yuya; Nagaoka, Noriyuki; Meerbeek, Bart Van; Yoshida, Yasuhiro

doi:10.1016/j.dental.2021.10.009

Cited by 9 publications

(5 citation statements)

References 26 publications

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“…It cannot prevent recurrent caries, which is one of the main reasons for the failure of the restorations [ 122 ]. The modifications of resin cement include the addition of antimicrobial compounds, such as silver nanoparticles, quaternary ammonium polyethyleneimine nanoparticles, cetylpyridinium chloride modified montmorillonite and chlorhexidine diacetate and ursolic acid [ 123 , 124 , 125 , 126 , 127 ]. Efforts have been made to determine the ideal concentrations of these compounds without adversely affecting the mechanical properties of the resin, while also retaining their antibacterial abilities [ 124 ].…”

Section: New Development Of Luting Cementsmentioning

confidence: 99%

Update on Dental Luting Materials

et al. 2022

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A dental luting material aids in the retention and stability of indirect restorations on the prepared tooth structure. In dentistry, clinicians are using a wide range of luting materials for the cementation of indirect restorations. Zinc oxide eugenol and non-eugenol cements, zinc phosphate cement, zinc polycarboxylate cement, glass ionomer cement and resin cements are common dental cements used in dentistry. Each luting material or cement possesses unique properties and clinical implications. An ideal luting cement should be biocompatible, insoluble, resistant to thermal and chemical assaults, antibacterial, aesthetic, simple and easy to use. It should have high strength properties under tension, shear and compression to resist stress at the restoration–tooth interface, as well as adequate working and setting times. So far, no luting material possesses all of these properties of an ideal cement. Scientists have been modifying the conventional luting cements to improve the material’s clinical performance and developing novel materials for clinical use. To achieve the best clinical outcome, clinicians should update their knowledge and gain a good understanding of the luting materials so that they can make a wise clinical decision on the material selection and obtain an insight into the development of luting cements. Therefore, the objective of this study is to provide a discussion on the physical, chemical, adhesive and aesthetic properties of common luting materials. The clinical indications of these luting materials are suggested based on their properties. In addition, overviews of the modification of the conventional luting materials and the newly developed luting materials are provided.

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Section: New Development Of Luting Cementsmentioning

confidence: 99%

Update on Dental Luting Materials

et al. 2022

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“…To observe the bactericidal and microbicidal activity, direct contact tests are used [6]. This method involves fluorescence microscopy, confocal laser scanning microscopy (CSLM), and SEM to image capture the biofilms growing on material disks [6,[21][22][23][24][25]. In this study, we measured the CPC release and investigated the biofilm inhibition by SEM using the same broth amounts.…”

Section: Discussionmentioning

confidence: 99%

Long-Term Antibacterial Efficacy of Cetylpyridinium Chloride-Montmorillonite Containing PMMA Resin Cement

et al. 2023

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Despite being able to adhesively restore teeth, adhesives and cement do not possess any anticariogenic protection potential, by which caries recurrence may still occur and reduce the clinical lifetime of adhesive restorations. Several antibacterial agents have been incorporated into dental adhesives and cement to render them anticariogenic. Due to an additional therapeutic effect, such materials are classified as ‘dental combination products’ with more strict market regulations. We incorporated cetylpyridinium chloride (CPC), often used for oral hygiene applications, into montmorillonite (CPC-Mont), the latter to serve as a carrier for controlled CPC release. CPC-Mont incorporated into tissue conditioner has been approved by the Pharmaceuticals and Medical Devices Agency (PmontMDA) in Japan. To produce a clinically effective dental cement with the antibacterial potential to prevent secondary caries, we incorporated CPC-Mont into PMMA resin cement. We measured the flexural strength, shear bond strength onto dentin, CPC release, and the biofilm-inhibition potential of the experimental CPC-Mont-containing PMMA cement. An 8 and 10 wt% CPC-Mont concentration revealed the antibacterial potential without reducing the mechanical properties of the PMMA cement.

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“…Dental adhesives and cements generally do not contain antibacterial agents, which may result in caries recurrence and reduce the restorative material's lifespan. MMT has frequently been used as a carrier for CPC, and is widely used in oral hygienic products such as in dental adhesives and cements [44,89,90].…”

Section: Cetylpyridinium Chloride (Cpc) -Montmorillonitementioning

confidence: 99%

Montmorillonite in dentistry: a review of advances in research and potential clinical applications

Prasad Kumara,

Deng,

Cooper

et al. 2024

Mater. Res. Express

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Montmorillonite (MMT) is a biocompatible, cost-effective phyllosilicate mineral clay material with a nanolayered structure belonging to the smectite group. MMT is frequently used as an adsorbent catalyst in organic synthesis, food additives, cosmetics, medical applications and many other applications in varying industries. MMT has been incorporated into numerous experimental dental restorative materials as a reinforcing filler due to its high aspect ratio, forming interfacial solid bonds with the polymer matrix. The relatively high cation exchange capacity and layered structure of MMT pave the way as a medium for drug delivery systems. Furthermore, the incorporation of ions such as calcium, fluoride, silver, and zinc potentially increase the remineralization properties and antibacterial properties of MMT-based dental materials. Despite modern dental restorative materials having advanced significantly with innovations in material nanoscience, challenges such as biocompatibility, inadequate mechanical properties, marginal leakage, polymerization shrinkage, aesthetic concerns, and overall costs remain to be addressed. This review investigates the potential of montmorillonite (MMT) in dentistry, emphasizing its distinctive properties, composite formulations, and applications. It assesses the current state of research in these areas, aiming to highlight existing gaps in knowledge, emerging trends, and lesser-known applications of MMT-based materials. The review underscores MMT's promise as an alternative material across various dental applications while noting the scarcity of research on completed products and in vivo clinical studies.

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Novel composite cement containing the anti-microbial compound CPC-Montmorillonite

Cited by 9 publications

References 26 publications

Update on Dental Luting Materials

Update on Dental Luting Materials

Long-Term Antibacterial Efficacy of Cetylpyridinium Chloride-Montmorillonite Containing PMMA Resin Cement

Montmorillonite in dentistry: a review of advances in research and potential clinical applications

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