Novel comb-type hydrogels of net-[PP-g-AAc]-g-4VP synthesized by gamma radiation, with possible application on Cu2+ immobilization

Lazo, Luz Maria; Burillo, Guillermina

doi:10.1016/j.radphyschem.2009.08.033

Cited by 15 publications

(4 citation statements)

References 30 publications

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“…On the other hand, P4VP also has promising potential applications because it shows biocompatibility with human cells; is cationic in aqueous medium and its pKa is close to 5 . P4VP graft copolymers are very interesting because they show the ability to retain metallic ions, anti‐inflammatory, or antimicrobial drugs; besides, also it has the ability to affix anti‐cancer drugs when is grafted onto graphene oxide …”

Section: Introductionmentioning

confidence: 99%

Comonomer effect: Switching the lower critical solution temperature to upper critical solution temperature in thermo‐pH sensitive binary graft copolymers

Pino‐Ramos

Cedillo

López‐Barriguete

et al. 2019

J of Applied Polymer Sci

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Hydrophilic biocompatible surfaces can be obtained by grafting stimuli‐sensitive polymers onto commercially available medical devices. Thermo and pH‐responsive polymers are two of the most studied materials due to their potential application as drug delivery systems. Poly(N‐vinylcaprolactam) has a lower critical solution temperature (LCST) near to physiological temperature. However, when it is grafted with pH‐sensitive moieties its LCST it is affected undergoing remarkable displacements. We studied the effect of acrylic acid (AAc), 4‐vinylpyridine (4VP), and 1‐vinylimidazole (Vim) on the LCST of N‐vinylcaprolactam (NVCL) grafted onto silicone rubber (SR), and SR‐g‐NVCL (32.5 °C). The binary graft copolymers were obtained by ionizing grafting radiation using the simultaneous technique; the samples were characterized by Fourier transform infrared attenuated total reflectance (FTIR‐ATR), cross‐polarization magic angle spinning nuclear magnetic resonance (CP/MAS 13C‐NMR), and thermogravimetrical analysis (TGA). LCST value was dramatically affected by the comonomer content; even it was observed the switching from LCST to upper critical solution temperature (UCST) for (SR‐g‐NVCL)‐g‐AAc and (SR‐g‐NVCL)‐g‐4VP samples. The observed behavior is rarely reported for binary graft copolymers. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 48170.

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Section: Introductionmentioning

confidence: 99%

Comonomer effect: Switching the lower critical solution temperature to upper critical solution temperature in thermo‐pH sensitive binary graft copolymers

Pino‐Ramos

Cedillo

López‐Barriguete

et al. 2019

J of Applied Polymer Sci

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“…Similarly, the hydrogels based on poly(NIPA) are in the swollen state below the LCST while in the shrunken state above the LCST [47]. 4‐VP is a commonly used monomer to fabricate the pH‐sensitive hydrogels [48]. P(4‐VP) contains weak polybase, whose swelling and collapsing process results from the protonation and deprotonation of the pyridine groups.…”

Section: Resultsmentioning

confidence: 99%

Preparation and Characterization of Thermal and pH Dual Sensitive Hydrogel Based on 1,3‐Dipole Cycloaddition Reaction

Wei

Liu

Zhu

et al. 2020

Polymer Engineering & Sci

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In this study, thermal and pH dual sensitive hydrogels were prepared via Cu-free 1,3-dipole cycloaddition between two copolymers which were modified by azide and maleimide functional groups, respectively. First, the thermally sensitive terpolymers were fabricated via conventional free-radical polymerization of N-isopropylacrylamide, hydroxyethyl methacrylate (HEMA), and N,N-dimethylacrylamide (DMA). Then, polymeric dipolarophiles were synthesized via the esterification between the above terpolymers and N-maleoyl alanine. Similarly, the pH-sensitive terpolymers were also fabricated via conventional free-radical polymerization of 4-vinylpyridine, HEMA, and DMA, and then, polymeric dipoles were acquired via the decoration of the as-prepared terpolymers with 2-azidoacetic acid. Afterward, the smart hydrogels were fabricated via the aqueous 1,3-dipole cycloaddition reaction between the as-prepared polymeric dipolarophiles and dipoles without the use of catalysts. The results of swelling measurements confirm that the hydrogels possessed thermal and pH dual sensitivity. Moreover, the investigation of the behavior of oscillatory swelling shrinking indicates their sensitivity to temperature and pH was reversible and repeatable, which is of great significance for the repeated use of the prepared hydrogels. The proposed strategy demonstrates a great application prospects in the preparation of hydrogels as there were no catalysts and organic solvents employed. POLYM. ENG. SCI., 60:917-924, 2020.

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“…The pH-sensitive response of PAAc ascribed to carboxylic groups (COOH) allows for further chemical reactions to acquire or generate new functional groups [41]. In this context, the functionalization of urinary catheters with PAAc provides numerous binding points for the ionic interaction with Zn ++ ions, which, once bound, can be subsequently reduced to form nanoparticles [9].…”

Section: Introductionmentioning

confidence: 99%

Inhibition of Adherence and Biofilm Formation of Pseudomonas aeruginosa by Immobilized ZnO Nanoparticles on Silicone Urinary Catheter Grafted by Gamma Irradiation

et al. 2023

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Nosocomial infections caused by microbial biofilm formation on biomaterial surfaces such as urinary catheters are complicated by antibiotic resistance, representing a common problem in hospitalized patients. Therefore, we aimed to modify silicone catheters to resist microbial adherence and biofilm formation by the tested microorganisms. This study used a simple direct method to graft poly-acrylic acid onto silicone rubber films using gamma irradiation to endow the silicone surface with hydrophilic carboxylic acid functional groups. This modification allowed the silicone to immobilize ZnO nanoparticles (ZnO NPs) as an anti-biofilm. The modified silicone films were characterized by FT-IR, SEM, and TGA. The anti-adherence ability of the modified silicone films was evidenced by the inhibition of biofilm formation by otherwise strong biofilm-producing Gram-positive, Gram-negative, and yeast clinical isolates. The modified ZnO NPs grafted silicone showed good cytocompatibility with the human epithelial cell line. Moreover, studying the molecular basis of the inhibitory effect of the modified silicone surface on biofilm-associated genes in a selected Pseudomonas aeruginosa isolate showed that anti-adherence activity might be due to the significant downregulation of the expression of lasR, lasI, and lecB genes by 2, 2, and 3.3-fold, respectively. In conclusion, the modified silicone catheters were low-cost, offering broad-spectrum anti-biofilm activity with possible future applications in hospital settings.

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Novel comb-type hydrogels of net-[PP-g-AAc]-g-4VP synthesized by gamma radiation, with possible application on Cu2+ immobilization

Cited by 15 publications

References 30 publications

Comonomer effect: Switching the lower critical solution temperature to upper critical solution temperature in thermo‐pH sensitive binary graft copolymers

Comonomer effect: Switching the lower critical solution temperature to upper critical solution temperature in thermo‐pH sensitive binary graft copolymers

Preparation and Characterization of Thermal and pH Dual Sensitive Hydrogel Based on 1,3‐Dipole Cycloaddition Reaction

Inhibition of Adherence and Biofilm Formation of Pseudomonas aeruginosa by Immobilized ZnO Nanoparticles on Silicone Urinary Catheter Grafted by Gamma Irradiation

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