Novel class of organic crystal scintillators based on aggregation-induced emission

Satô, Atsushi; Koshimizu, Masanori; Fujimoto, Yutaka; Komatsuzaki, Shusuke; Kishimoto, Shunji; Asai, Keisuke

doi:10.1039/d2qm00187j

Cited by 15 publications

(9 citation statements)

References 46 publications

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“…DQM-OH, DQMF-OH, and DQMCl-OH were obtained by Knoevenagel condensation reaction of compound 3 with compounds 4 a, 4 b, and 4 c, respectively. The intermediates and final compounds were well-characterized by 1 H, 13 C, and 19 F NMR spectroscopy and HRMS in the Supporting Information (Figures S1-S14). In addition, we also confirmed the structure of DQM-OH, DQMF-OH, and DQMCl-OH by single-crystal structure analysis (Figure 1B).…”

Section: Resultsmentioning

confidence: 99%

“…Commercial Endoplasmic Reticulum probe ETR and Mitochondrial probe MTDR were purchased from Beyotime. 1 H NMR (400 MHz), 13 C NMR (100 MHz) and 19 F NMR (376 MHz) spectra were recorded on a Bruker AVANCE III spectrometer using tetramethylsilane as the internal standard. High-resolution mass spectra (HRMS) were recorded on an Agilent Technologies 6510 Q-TOF LC/ MS instrument operated in the ESI mode.…”

Section: General Informationmentioning

confidence: 99%

“…[7,[10][11][12] The mechanism of restriction of intramolecular motion (RIM) proposed by Tang et al has been widely accepted to explain the unique fluorescence of AIEgens. [7] Guided by the RIM mechanism, scientists around the world have made great efforts to develop various kinds of AIEgens, including siloles, [13][14][15] tetraphenylethylenes, [16][17][18] tetraphenylpyrazines, [19][20][21] acrylonitriles, [22][23][24] and metal complexes, [25][26][27] for molecule detection, bioimaging, disease diagnosis, and therapy. [28][29][30][31][32][33][34] Among these, the quinolinemalononitrile core developed by Zhu and co-workers has become an attractive building block for constructing multiple functional AIEgens, because of their facile synthesis and bright solid-state fluorescence.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Halogenation on Quinoline‐Malononitrile‐based AIEgens: Photophysical Properties Investigation and Wash‐Free Imaging

Feng

Meng

Niu

2023

Chemistry An Asian Journal

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Developing halogen-functionalized fluorescent dyes with intriguing photophysical properties, including enhanced photostability, is particularly important for bioimaging. In this work, we synthesized two new halogenfunctionalized aggregation-induced emission (AIE)-active molecules, DQMF-OH and DQMCl-OH, based on the quinoline-malononitrile chromophore. The halogen effect on the photophysical characteristics was detailedly studied by absorption and fluorescence spectroscopy, density functional theory calculations, and crystal structures. Compared with non-halogen substituted AIE luminogen (AIEgen) DQM-OH, the halogen substituted DQMF-OH and DQMCl-OH exhibited red-shifted absorptions and emissions in the solution and solid state. In addition, DQMF-OH and DQMCl-OH also possessed enhanced fluorescence toward viscosity changes. These AIEgens served as remarkable imaging tools for cell tracking in a wash-free manner. Furthermore, DQMF-OH and DQMCl-OH showed much more excellent photobleaching resistance than DQM-OH. Our work sheds new light on developing fluorescent halogenated dyes with enhanced photophysical performances for biological applications.

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Section: Resultsmentioning

confidence: 99%

Section: General Informationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of Halogenation on Quinoline‐Malononitrile‐based AIEgens: Photophysical Properties Investigation and Wash‐Free Imaging

Feng

Meng

Niu

2023

Chemistry An Asian Journal

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“…Organic scintillators have low scintillation light yields and rapid responsiveness. (12)(13)(14) As organic-inorganic hybrid materials, layered perovskite organic-inorganic compounds exhibiting the efficient and fast emission of quantum-confined free excitons have been used as scintillators. (4,(15)(16)(17) Also, inorganic-nanoparticle-loaded organic scintillators have been developed, as introduced later.…”

Section: Introductionmentioning

confidence: 99%

Development of Ce-doped Gd3Al5−yGayO12 Nanoparticle Scintillators

Koshimizu¹,

Fujimoto²,

Asai³

2023

Sensors and Materials

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We synthesized Ce-doped Gd 3 Al 5−y Ga y O 12 (GAGG) nanoparticle scintillators for obtaining efficient emission in living bodies upon X-ray irradiation from outside. To obtain a high photoluminescence quantum yield (QY), the chemical composition and synthesis conditions were optimized. The highest QY of 90%, which is higher than that of a commercially available Ce-doped GAGG single-crystal scintillator (87%), was achieved with the composition for Gd:Al:Ga = 3:3:2, a Ce concentration of 0.1 mol% relative to (Gd + Ce), aging at room temperature for 1 d, and a calcination temperature of 1300 °C. The size of the particles was 200-300 nm. A dominant emission band at around 550 nm was observed in the photoluminescence and X-ray-induced radioluminescence spectra and attributed to the 5d-4f transition of Ce 3+ . The high photoluminescence QY and appropriate size for applications in living bodies indicated that nanoparticle scintillators based on Ce-doped GAGG were successfully developed.

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“…At present, many types of signal markers have been identified, such as colorimetrically labeled gold dyes ( Huang et al, 2020 ) and organic dye ( Sato et al, 2022 ) and non-colorimetrically labeled fluorescent dyes ( Zhang et al, 2020 ), quantum dots ( Luo et al, 2022 ), magnetic beads ( Liu et al, 2015 ), and microspheres ( Yang et al, 2020 ). The fluorescence immunoassay received great attention due to its selectivity, sensitivity, and easy operation.…”

Section: Introductionmentioning

confidence: 99%

Development of fluorescent lateral flow immunoassay for SARS-CoV-2-specific IgM and IgG based on aggregation-induced emission carbon dots

Zhang

et al. 2022

Front. Bioeng. Biotechnol.

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Understanding the dynamic changes in antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is essential for evaluating the effectiveness of the vaccine and the stage for the recovery of the COVID-19 disease. A rapid and accurate method for the detection of SARS-CoV-2-specific antibodies is still urgently needed. Here, we developed a novel fluorescent lateral flow immunoassay (LFA) platform for the detection of SARS-CoV-2-specific IgM and IgG by the aggregation-induced emission carbon dots conjugated with the SARS-CoV-2 spike protein (SSP). The aggregation-induced emission carbon dots (AIE-CDs) are one of the best prospect fluorescent probe materials for exhibiting high emission efficiency in both aggregate and solid states. The AIE-CDs were synthesized and displayed dual fluorescence emission, which provides a new perspective for the design of a high sensitivity testing system. In this work, the novel LFA platform adopted the AIE carbon dots, which are used to detect SARS-CoV-2-specific IgM and IgG conveniently. Furthermore, this sensor had a low LOD of 100 pg/ml. Therefore, this newly developed strategy has potential applications in the areas of public health for the advancement of clinical research.

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Novel class of organic crystal scintillators based on aggregation-induced emission

Abstract: We synthesized 1,1,2,3,4,5-hexaphenyl-1H-silole (HPS) crystals to develop organic crystal scintillators based on aggregation-induced emission (AIE).

Cited by 15 publications

References 46 publications

Effects of Halogenation on Quinoline‐Malononitrile‐based AIEgens: Photophysical Properties Investigation and Wash‐Free Imaging

Effects of Halogenation on Quinoline‐Malononitrile‐based AIEgens: Photophysical Properties Investigation and Wash‐Free Imaging

Development of Ce-doped Gd3Al5−yGayO12 Nanoparticle Scintillators

Development of fluorescent lateral flow immunoassay for SARS-CoV-2-specific IgM and IgG based on aggregation-induced emission carbon dots

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