Novel ciprofloxacin and norfloxacin-tetrazole hybrids as potential antibacterial and antiviral agents: Targeting S. aureus topoisomerase and SARS-CoV-2-MPro

Synthesis and Anticancer Activity of 1‐(Ethyl/Methyl)‐7‐(p‐Methoxybenzyl Amino) and 7‐Amino‐6‐Fluoroquinolone‐Boron Difluoride Complexes

“…Reducing an azide group at the C‐7 position [42–44] can also produce amine moieties. Azides are essential intermediates in medicinal chemistry, enabling the synthesis of heterocycles such as triazoles and tetrazoles, allowing quinolone‐triazole or tetrazole hybrids to be generated [45–48] …”

“…Azides are essential intermediates in medicinal chemistry, enabling the synthesis of heterocycles such as triazoles and tetrazoles, allowing quinolone-triazole or tetrazole hybrids to be generated. [45][46][47][48] Another successful route to 7-amino-fluoroquinolones uses p-methoxybenzyl amine (PMBA), notably achieving good yields under mild conditions. [49][50][51] In this method, nucleophilic aromatic substitution (S N A) occurs, forming the NÀ C bond between the PMBA and the fluoroquinolone ring, and subsequent hydrolysis of p-methoxybenzyl moiety under acid conditions yields 7-amino-fluoroquinolones.…”

Synthesis of tetrazole hybridized with thiazole, thiophene or thiadiazole derivatives, molecular modelling and antimicrobial activity

“…Because of the high density of nitrogen atoms in the ring structure, tetrazoles are very electron-deficient and polar, allowing them to engage in diverse hydrogen bonding interactions in several biological medications ( Fig. 1 ) ( Cardoso-Ortiz et al, 2023 ). We discovered biological activity for various heterocyclic derivatives connected to the tetrazole ring, such as thiophene-tetrazole, thiazole-tetrazole, and thiadiazole-tetrazole analogues, in the previous survey.…”