Novel chronotherapeutic rectal aminophylline delivery system for therapy of asthma

Shiohira, Hideo; Fujii, Makiko; Koizumi, Noriko; Kondoh, Masuo; Watanabe, Yoshihisa

doi:10.1016/j.ijpharm.2009.06.017

Cited by 23 publications

(17 citation statements)

References 22 publications

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“…However, the frequency of TP side-effects has recently reduced its usage. Inhaled TP has not been successful either, mostly due to the lack of retention in the airways and irritation [6][7]. The purpose of the present work was to develop TP loaded microspheres and to determine the physicochemical characteristics of the developed microspheres.…”

Section: Introductionmentioning

confidence: 99%

Sodium alginate microspheres for extending drug release: formulation and in vitro evaluation.

Soni¹,

Kumar²,

Namdeo³

2010

Int. J. Drug Delivery

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In the present study, spherical microspheres of theophylline (TP) using sodium alginate as the hydrophilic carrier were prepared to prolong the release. The shape, surface and size characteristics were determined by scanning electron microscopy. The microspheres were found to be discreet and spherical in shape and had a smoother surface. The mean diameter of seven alginate microspheres formulations were between 7.6 ± 0.52 and 22.35 ±0.31 μm. It was observed that mean particle size of the microspheres increased with an increase in the concentration of polymer. The entrapment efficiency was found to be in the range of 70-93%. Optimized alginate microspheres were found to possess good sphericity, size and adequate entrapment efficiency. The in vitro release studies were carried out in pH progression media (pH 1.2, 2.5, 4.5, 7 and 7.4 solutions). Results indicated that percent drug release decreased with an increased alginate concentration. TP-loaded Alginate microspheres showed extended in vitro drug release thus use of microspheres potentially offers sustained release profile along with improved delivery of TP.

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Section: Introductionmentioning

confidence: 99%

Sodium alginate microspheres for extending drug release: formulation and in vitro evaluation.

Soni¹,

Kumar²,

Namdeo³

2010

Int. J. Drug Delivery

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“…Rectal administration of aminophylline suppositories for asthma therapy has been reported as another novel chronopharmaceutical delivery system [13]. Recently drug containing nanoformulation appears to be a new therapeutic strategy in chronotherapy that can increase for example breast cancer curability with no added side effects, costs, and risks for the patients [14].…”

Section: Recently Available Different Chronopharmaceutical Technologiesmentioning

confidence: 99%

“…Rectal administration of aminophylline suppositories for asthma therapy has been reported as another novel chronopharmaceutical delivery system [13]. It consisted of sustained release hollow-type (SR-HT) suppositories using sodium alginate, sodium polyacrylate or polyacrylate-PANa (PA-PANa) co-polymer as gelling polymers/gel agent.…”

Section: Chronotherapy With Rectal Suppositories Of β 2 -Agonist Aminmentioning

confidence: 99%

Chronotherapeutics — A chronopharmaceutical approach to drug delivery in the treatment of asthma

Nainwal

2012

Journal of Controlled Release

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“…Examples of such systems include ChronoDose™, crystal reservoir [18] and thermoresponsive membrane systems [19]. For rectal routes, a novel chronopharmaceutical and rectal aminophylline delivery system for asthma therapy has been reported [20]. It consisted of a sustained-release hollow-type (SR-HT) suppositories using sodium alginate, sodium polyacrylate or polyacrylate-PANa (PA-PANa) co-polymer as gelling polymers/gel agent.…”

Section: Overview Of the Current Status Of Chronopharmaceutical Drmentioning

confidence: 99%

Chronopharmaceutical drug delivery systems: Hurdles, hype or hope?☆

Youan

2010

Advanced Drug Delivery Reviews

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The current advances in chronobiology and the knowledge gained from chronotherapy of selected diseases strongly suggest that “the one size fits all at all times” approach to drug delivery is no longer substantiated, at least for selected bioactive agents and disease therapy or prevention. Thus, there is a critical and urgent need for chronopharmaceutical research (e.g., design and evaluation of robust, spatially and temporally controlled drug delivery systems that would be clinically intended for chronotherapy by different routes of administration). This review provides a brief overview of current delivery system intended for chronotherapy. In theory, such an ideal “magic pill” preferably with affordable cost, would improve the safety, efficacy and patient compliance of old and new drugs. However, currently, there are three major hurdles for the successful transition of such system from laboratory to patient bedside. These include the challenges to identify adequate (i) rhythmic biomaterials and systems, (ii) rhythm engineering modeling, perhaps using system biology and (iii) regulatory guidance.

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Novel chronotherapeutic rectal aminophylline delivery system for therapy of asthma

Cited by 23 publications

References 22 publications

Sodium alginate microspheres for extending drug release: formulation and in vitro evaluation.

Sodium alginate microspheres for extending drug release: formulation and in vitro evaluation.

Chronotherapeutics — A chronopharmaceutical approach to drug delivery in the treatment of asthma

Chronopharmaceutical drug delivery systems: Hurdles, hype or hope?☆

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