Abstract:Arrhythmia follows chronobiology, thus necessitating the development of a time-dependent formulation for its treatment. The aim of the current work was to develop a solubility-enhanced chronotherapeutic system of felodipine, a widely prescribed antiarrhythmic. Systematically optimize hot-melt extrusion process was employed to formulate solubility-enhanced extrudates. The film casting method was adopted for the selection of polymers. Drug released at 5, 15, 30min was taken as response variables in 3 2 face-cent… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.