Novel chitosan-based nanobiohybrid membranes for wound dressing applications

Moghadas, Babak; Dashtimoghadam, Erfan; Mirzadeh, Hamid; Seidi, Farzad; Hasani-Sadrabadi, Mohammad Mahdi

doi:10.1039/c5ra23875g

Cited by 59 publications

(30 citation statements)

References 60 publications

(71 reference statements)

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“…2 Chitosan performs diverse biological functions, such as antifungal and antimicrobial activities, 3 immune-enhancing effects, 4 antioxidant activities, 5 and wound healing properties. 6,7 Thus, it is widely used in food production, agriculture, cosmetics, and biomedicine. 1 The above properties and functionalities are closely related to the degree of deacetylation (DD).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the degree of chitosan deacetylation via induced-electrical properties

Guo

Yang

et al. 2017

RSC Adv.

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Section: Introductionmentioning

confidence: 99%

Evaluation of the degree of chitosan deacetylation via induced-electrical properties

Guo

Yang

et al. 2017

RSC Adv.

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“…Para o material Q2 foi possível observar bandas de absorção referentes ao estiramento simétrico e assimétrico relativas à presença do grupo sulfato em 590 e 1222 cm -1 , respectivamente [32]. O deslocamento e aumento de intensidade da banda a 890 cm -1 pode ser atribuído à contribuição do grupo C-O-S confirmando a sulfatação da quitosana [33].…”

Section: Figuraunclassified

“…Este fato pode ser atribuído ao fato do ácido clorídrico favorecer as interações eletrostáticas entre as cadeias poliméricas, resultando em uma instabilidade estrutural e consequente desorientação dos planos cristalinos, no momento da acidificação [34,36] Já para o material Q2 observam-se picos que indicam uma maior organização estrutural, no entanto com valores de 2ɵ deslocados em relação à quitosana comercial. Estes deslocamentos podem ser resultantes das interações entre o grupo amino protonados da quitosana e os íons sulfato, resultando em uma maior organização dos planos da quitosana após o processo de acidificação, quando comparado com a amostra acidificada com HCl [33,36,37].…”

Section: Figuraunclassified

Catalisadores ácidos baseados na simples modificação da quitosana para a esterificação do ácido oleico

et al. 2018

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RESUMO A quitosana é um polímero linear com excelentes propriedades físico-químicas e tem sido amplamente utilizada em uma variedade de aplicações, incluindo como catalisador em vários tipos de reações. Neste trabalho, a quitosana comercial foi modificada, de modo a obter um material ativo e estável para ser utilizado como catalisador em reações de esterificação. Para este fim, a quitosana foi submetida à hidrólise ácida usando soluções de HCl ou H2SO4. A quitosana ácida foi então, caracterizada e avaliada na reação de esterificação do ácido oleico com metanol. Embora, a modificação da quitosana com soluções diluídas de ácidos inorgânicos seja um método simples para a preparação de catalisador heterogêneo ácido, há evidências que os materiais, apesar de apresentarem bons resultados de conversão do ácido oleico, não são estáveis frente à lixiviação das espécies ativa para o meio reacional nas condições avaliadas.

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“…Hydrophilic membranes based on PVAl and chitosan have been synthesized because the presence of chitosan improves the mechanical, hydrophilic and antibacterial properties of membranes obtained from PVAl [13,14]. These membranes modified by the presence of nanoclays for use in dressings have been obtained with good mechanical and absorption properties [15,16].…”

Section: Introductionmentioning

confidence: 99%

Obtaining Hydrogels based on PVP/PVAL/Chitosan Containing Pseudoboehmite Nanoparticles for Application in Drugs

Miranda¹,

Cunha²,

Barbosa³

et al. 2018

Hydrogels

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People with skin lesions caused by burns, ulcerations and other complications, independent of degree and extension of the problem, has induced the search for methods and materials to optimize the process of tissue repair in matter of time and quality. Thus, materials made by synthetic polymers have been used and improved due to overwhelming demand. The efficacy of dressings and bandage depends on a variety of factors such as biocompatibility, composition uniformity, low cost, long validity, flexibility, and so on. In this chapter, hydrophilic membranes based on polyvinylpyrrolidone-PVP/poly(vinyl alcohol)-PVAl and chitosan containing nanoparticles of pseudoboehmite for use in pharmaceuticals were developed and studied. The hydrogels were obtained by ionizing radiation in electronbeam accelerator at a dose of 25 kGy and characterized by mechanical, thermal and physicochemical tests. Pseudoboehmite nanoparticles were obtained from aluminum nitrate by a sol-gel process. The characterization of the hydrogels was done by various tests such as tensile, swelling, thermal analysis, sol-gel fraction and dynamic mechanical analysis. The results show that the presence of PVAl hydrophilic membrane causes lower degree of swelling, greater attraction and greater resistance to elongation at break in tension, although significantly lower fraction of gel membranes contains only agar and PVP. It was verified that the presence of chitosan nanoparticles and pseudoboehmite promotes a decrease in the formation of cross-links during irradiation of hydrophilic membranes.

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Novel chitosan-based nanobiohybrid membranes for wound dressing applications

Abstract: Montmorillonite nanolayers were treated with chitosan sulfate, as a functional biocompatibilizer, and then exfoliated in chitosan matrix to design nanohybrid membranes for potential wound dressing applications with enhanced physical, mechanical and antibacterial properties.

Cited by 59 publications

References 60 publications

Evaluation of the degree of chitosan deacetylation via induced-electrical properties

Evaluation of the degree of chitosan deacetylation via induced-electrical properties

Catalisadores ácidos baseados na simples modificação da quitosana para a esterificação do ácido oleico

Obtaining Hydrogels based on PVP/PVAL/Chitosan Containing Pseudoboehmite Nanoparticles for Application in Drugs

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