Novel chiral ionic liquids stationary phases for the enantiomer separation of chiral acid by high‐performance liquid chromatography

He, Shanshan; He, Yunchao; Cheng, Lingping; Wu, Yaling; Ke, Yanxiong

doi:10.1002/chir.22839

Cited by 18 publications

(10 citation statements)

References 34 publications

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Section: Chromatographymentioning

confidence: 99%

“…reaction for the linkage of the chiral selector to the surface of silica sphere [84]. However, it is strange that just a few articles related to ICSs in HPLC are reported in recent 3 years [55,60,61,[84][85][86]. It is mainly due to the reason that the addition of ionic selectors cannot improve the recognition efficiency obviously compared with CE.…”

Section: Chromatographymentioning

confidence: 99%

See 1 more Smart Citation

Recent advances of the ionic chiral selectors for chiral resolution by chromatography, spectroscopy and electrochemistry

Fan

et al. 2021

J of Separation Science

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Ionic chiral selectors have been received much attention in the field of asymmetric catalysis, chiral recognition, and preparative separation. It has been shown that the addition of ionic chiral selectors can enhance the recognition efficiency dramatically due to the presence of multiple intermolecular interactions, including hydrogen bond, π-π interaction, van der Waals force, electrostatic ion-pairing interaction, and ionic-hydrogen bond. In the initial research stage of the ionic chiral selectors, most of work center on the application in chromatographic separation (capillary electrophoresis, high-performance liquid chromatography, and gas chromatography). Differently, more and more attention has been paid on the spectroscopy (nuclear magnetic resonance, fluorescence, ultraviolet and visible absorption spectrum, and circular dichroism spectrum) and electrochemistry in recent years. In this tutorial review as regards the ionic chiral selectors, we discuss in detail the structural features, properties, and their application in chromatography, spectroscopy, and electrochemistry.

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Section: Chromatographymentioning

confidence: 99%

Section: Chromatographymentioning

confidence: 99%

Recent advances of the ionic chiral selectors for chiral resolution by chromatography, spectroscopy and electrochemistry

Fan

et al. 2021

J of Separation Science

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“…[194], Copyright (2020), with permission from Elsevier. More recently, novel CSPs, based on chiral imidazole bonded to the surface of the silica sphere with strong anion exchange properties, were prepared by He et al [196]. The ionic liquid chiral selector was synthesized by ring-opening of cyclohexene oxide with imidazole or 5,6-dimethylbenzimidazole and modified by appropriate substitute groups.…”

Section: Inmentioning

confidence: 99%

Chiral Ionic Liquids: Structural Diversity, Properties and Applications in Selected Separation Techniques

Flieger

Feder‐Kubis

Tatarczak-Michalewska

2020

IJMS

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Ionic liquids (ILs) are chemical compounds composed of ions with melting points below 100 °C exhibiting a design feature. ILs are commonly used as the so-called green solvents, reagents or highly efficient catalysts in varied chemical processes. The huge application potential of ionic liquids (IL) justifies the growing interest in these compounds. In the last decade, increasing attention has been devoted to the development of new methods in the synthesis of stable chiral ionic liquids (CILs) and their application in various separation techniques. The beginnings of the successful use of CILs to separate enantiomers date back to the 1990 s. Most chiral ILs are based on chiral cations or chiral anions. There is also a limited number of CILs possessing both a chiral cation and a chiral anion. Due to the high molecular diversity of both ions, of which at least one has a chiral center, we have the possibility to design a large variety of optically active structures, thus expanding the range of CIL applications. Research utilizing chiral ionic liquids only recently has become more popular. However, it is the area that still has great potential for future development. This review aimed to describe the diversity of structures, properties and examples of applications of chiral ionic liquids as new chiral solid materials and chiral components of the anisotropic environment, providing chiral recognition of enantiomeric analytes, which is useful in liquid chromatography, countercurrent chromatography and other various CIL-based extraction techniques including aqueous biphasic (ABS) extraction systems, solid–liquid two-phase systems, liquid–liquid extraction systems with hydrophilic CILs, liquid–liquid extraction systems with hydrophobic CILs, solid-phase extraction and induced-precipitation techniques developed in the recent years. The growing demand for pure enantiomers in the pharmaceutical and food industries sparks further development in the field of extraction and separation systems modified with CILs highlighting them as affordable and environmentally friendly both chiral selectors and solvents.

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“…The imidazolium cation (single or multiple) is most commonly used to modify the stationary phase surface [160]. Furthermore, analytes were also separated on a column prepared using polymeric or chiral ILs [161,162]. There are many ways in the literature for obtaining IL-modified stationary phases based on various chemical reactions and substrates.…”

Section: Ionic Liquid Stationary Phasesmentioning

confidence: 99%

The Influence of Ionic Liquids on the Effectiveness of Analytical Methods Used in the Monitoring of Human and Veterinary Pharmaceuticals in Biological and Environmental Samples—Trends and Perspectives

et al. 2020

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Recent years have seen the increased utilization of ionic liquids (ILs) in the development and optimization of analytical methods. Their unique and eco-friendly properties and the ability to modify their structure allows them to be useful both at the sample preparation stage and at the separation stage of the analytes. The use of ILs for the analysis of pharmaceuticals seems particularly interesting because of their systematic delivery to the environment. Nowadays, they are commonly detected in many countries at very low concentration levels. However, due to their specific physiological activity, pharmaceuticals are responsible for bioaccumulation and toxic effects in aquatic and terrestrial ecosystems as well as possibly upsetting the body’s equilibrium, leading to the dangerous phenomenon of drug resistance. This review will provide a comprehensive summary of the use of ILs in various sample preparation procedures and separation methods for the determination of pharmaceuticals in environmental and biological matrices based on liquid-based chromatography (LC, SFC, TLC), gas chromatography (GC) and electromigration techniques (e.g., capillary electrophoresis (CE)). Moreover, the advantages and disadvantages of ILs, which can appear during extraction and separation, will be presented and attention will be given to the criteria to be followed during the selection of ILs for specific applications.

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Novel chiral ionic liquids stationary phases for the enantiomer separation of chiral acid by high‐performance liquid chromatography

Cited by 18 publications

References 34 publications

Recent advances of the ionic chiral selectors for chiral resolution by chromatography, spectroscopy and electrochemistry

Recent advances of the ionic chiral selectors for chiral resolution by chromatography, spectroscopy and electrochemistry

Chiral Ionic Liquids: Structural Diversity, Properties and Applications in Selected Separation Techniques

The Influence of Ionic Liquids on the Effectiveness of Analytical Methods Used in the Monitoring of Human and Veterinary Pharmaceuticals in Biological and Environmental Samples—Trends and Perspectives

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