Novel childhood asthma genes interact with in utero and early-life tobacco smoke exposure

Scholtens, Salome; Postma, Dirkje S.; Moffatt, Miriam F.; Panasevich, Sviatlana; Granell, Raquel; Henderson, John; Melén, Erik; Nyberg, Fredrik; Pershagen, Göran; Jarvis, Déborah; Ramasamy, Adaikalavan; Wjst, Matthias; Svanes, Cecilie; Bouzigon, Emmanuelle; Demenais, Florence; Kauffmann, F.; Siroux, Valérie; Mutius, Erika von; Ege, Markus; Braun‐Fahrländer, Charlotte; Genuneit, Jon; Brunekreef, Bert; Smit, Henriëtte A.; Wijga, Alet H.; Kerkhof, Marjan; Ivan, Cristina; Imboden, Medea; Thun, Gian Andri; Probst‐Hensch, Nicole; Freidin, Maxim B.; Bragina, E. Yu.; Deev, I.A.; Puzyrev, V. P.; Daley, Denise; Park, Julie; Becker, Allan B.; Chan‐Yeung, Moira; Kozyrskyj, Anita L.; Paré, Peter D.; Marenholz, Ingo; Lau, Susanne; Keil, Thomas; Lee, Young Ae; Kabesch, Michael; Wijmenga, Cisca; Franke, Lude; Nolte, Ilja M.; Vonk, Judith M.; Kumar, Ashish; Farrall, Martin; Cookson, William; Strachan, David P.; Koppelman, Gerard H.; Boezen, H. Marike

doi:10.1016/j.jaci.2013.08.049

Cited by 48 publications

(35 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Studies investigating genetic determinants of obstructive lung disease and the effect of early-life smoke exposure on gene expression have found at least three COPD genes whose expression may be influenced by in utero tobacco smoke exposure [69,70]. Epigenetic changes may account for such generational effects [71].…”

Section: Resultsmentioning

confidence: 99%

The association between environmental tobacco smoke exposure and childhood respiratory disease: a review

Vanker

Gie

Zar

2017

Expert Review of Respiratory Medicine

145

View full text Add to dashboard Cite

Introduction: Childhood respiratory illness is a major cause of morbidity and mortality particularly in low and middle-income countries. Environmental tobacco smoke (ETS) exposure is a recognised risk factor for both acute and chronic respiratory illness.Areas covered: The aim of this paper was to review the epidemiology of ETS exposure and impact on respiratory health in children. We conducted a search of 3 electronic databases of publications on ETS and childhood respiratory illness from 1990–2015. Key findings were that up to 70% of children are exposed to ETS globally, but under-reporting may mask the true prevalence. Maternal smoking and ETS exposure influence infant lung development and are associated with childhood upper and lower respiratory tract infection, wheezing or asthma. Further, exposure to ETS is associated with more severe respiratory disease. ETS exposure reduces lung function early in life, establishing an increased lifelong risk of poor lung health.Expert commentary: Urgent and effective strategies are needed to decrease ETS exposure in young children to improve child and long-term lung health in adults especially in low and middle income countries where ETS exposure is increasing.

show abstract

Section: Resultsmentioning

confidence: 99%

The association between environmental tobacco smoke exposure and childhood respiratory disease: a review

Vanker

Gie

Zar

2017

Expert Review of Respiratory Medicine

145

View full text Add to dashboard Cite

show abstract

“…Earlier studies by SEKHON and co-workers [52,53] found that, after crossing the placenta, nicotine can interact directly with nicotinic acetylcholine receptors in the lungs of monkeys, thereby altering lung development and resulting in impaired lung function at birth. More recent research has suggested an interaction of in utero and earlylife smoke exposure with asthma susceptibility genes [54]. This finding highlights the fact that there are still unresolved questions regarding the mechanisms by which exposure to tobacco smoke impairs lung development and enhances respiratory disease.…”

Section: Second-hand Smoke Exposurementioning

confidence: 89%

Early-life origins of chronic respiratory diseases: understanding and promoting healthy ageing

et al. 2014

View full text Add to dashboard Cite

Chronic obstructive respiratory disorders such as asthma and chronic obstructive pulmonary disease often originate early in life. In addition to a genetic predisposition, prenatal and early-life environmental exposures have a persistent impact on respiratory health. Acting during a critical phase of lung development, these factors may change lung structure and metabolism, and may induce maladaptive responses to harmful agents, which will affect the whole lifespan.Some environmental factors, such as exposure to cigarette smoke, type of childbirth and diet, may be modifiable, but it is more difficult to influence other factors, such as preterm birth and early exposure to viruses or allergens.Here, we bring together recent literature to analyse the critical aspects involved in the early stages of lung development, going back to prenatal and perinatal events, and we discuss the mechanisms by which noxious factors encountered early on may have a lifelong impact on respiratory health.We briefly comment on the need for early disease biomarkers and on the possible role of ''-omic'' technologies in identifying risk profiles predictive of chronic respiratory conditions. Such profiles could guide the ideation of effective preventive strategies and/or targeted early lifestyle or therapeutic interventions. @ERSpublications Early-life factors have a role in onset of asthma and COPD; early postnatal interventions may promote lung health http://ow.ly/BvUrx

show abstract

“…Most previous interaction studies of genetic variants with ETS on asthma risk had difficulties to show significant interaction and/or replication in independent samples [14,16,20]. Indeed replication of GxE interaction is much more difficult to achieve than replication of single SNP association.…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly the recent GWIS for childhood asthma and ETS exposure [20] indicated interaction of ETS exposure with PACRG gene (Parkin coregulated gene), which, similarly to DNAH9, has an important role in motile cilia function. Additionally, the pathway of cilia-related genes has been recently shown to be highly relevant to a biomarker of asthma, the FeNO (Fractional exhaled Nitric Oxide), by a bronchial epithelial cell gene expression study [43].…”

Section: Discussionmentioning

confidence: 99%

“…PCDH1 (protocadherin 1) and ADAM33 (ADAM metallopeptidase domain 33) genes that were identified as susceptibility genes for BHR through positional cloning [16,17], were also found to interact with ETS exposure in utero and/or in early life [16,18,19]. More recently, a meta-analysis of genome-wide interaction studies (GWIS) of childhood asthma suggested potential interaction of a number of genes with ETS exposure [20].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Interaction between the DNAH9 gene and early smoke exposure in bronchial hyperresponsiveness

et al. 2016

Self Cite

View full text Add to dashboard Cite

A previous genome-wide linkage scan of bronchial hyperresponsiveness (BHR) in the French Epidemiological study on the Genetics and Environment of Asthma (EGEA) families, performed in the presence of a gene×early-life environmental tobacco smoke (ETS) exposure interaction, showed the strongest interaction in the 17p11 region where linkage was detected only among unexposed siblings. Our goal was to conduct fine-scale mapping of 17p11 to identify single nucleotide polymorphisms (SNPs) interacting with ETS that influence BHR.Analyses were performed in 388 French EGEA asthmatic families, using a two-step strategy: 1) selection of SNPs displaying family-based association test (FBAT) association signals (p≤0.01) with BHR in unexposed siblings, and 2) a FBAT homogeneity test between exposed and unexposed siblings plus a robust log-linear interaction test.A single SNP reached the threshold (p≤3×10−3) for significant interaction with ETS using both interaction tests, after accounting for multiple testing. Results were replicated in 253 French-Canadian families, but not in 341 UK families, probably due in part to differences in phenotypic features between datasets.The SNP showing significant interaction with ETS belongs to DNAH9 (dynein, axonemal, heavy chain 9), a promising candidate gene involved in respiratory cilia mobility and associated with primary ciliary dyskinesia, a disease associated with abnormalities of pulmonary function.

show abstract

Novel childhood asthma genes interact with in utero and early-life tobacco smoke exposure

Cited by 48 publications

References 9 publications

The association between environmental tobacco smoke exposure and childhood respiratory disease: a review

The association between environmental tobacco smoke exposure and childhood respiratory disease: a review

Early-life origins of chronic respiratory diseases: understanding and promoting healthy ageing

Interaction between the DNAH9 gene and early smoke exposure in bronchial hyperresponsiveness

Contact Info

Product

Resources

About