Novel characterization of CXCR4 expressing cells in uninfected and herpes simplex virus-1 infected corneas

Suvas, Pratima Krishna; Setia, Mizumi; Rana, Mashidur; Chakraborty, Anish; Suvas, Susmit

doi:10.1016/j.jtos.2023.02.006

Cited by 2 publications

(1 citation statement)

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“…The transmission properties of HSV keratitis would be better managed if the role of the CD4+ TRM (Tissue Resident Memory T cells) and their induction by vaccines is well understood[ 210 ]. CXCR4-expressing cells may be key in the migration of neutrophils and the progression of lymphatics onto HSV-infected corneas[ 211 ]. During latent stages, viral proteins maintain low-level sporadic expression without full virion production, and ganglionic HSV-1 specific CD8+ T cell retention during latency serves protective functions[ 212 ].…”

Section: Immune Responses In Herpes Simplex Keratitis: Implications F...mentioning

confidence: 99%

Herpes simplex keratitis: A brief clinical overview

Musa,

Enaholo,

Aluyi-Osa

et al. 2024

World J Virol

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The aim of our minireview is to provide a brief overview of the diagnosis, clinical aspects, treatment options, management, and current literature available regarding herpes simplex keratitis (HSK). This type of corneal viral infection is caused by the herpes simplex virus (HSV), which can affect several tissues, including the cornea. One significant aspect of HSK is its potential to cause recurrent episodes of inflammation and damage to the cornea. After the initial infection, the HSV can establish a latent infection in the trigeminal ganglion, a nerve cluster near the eye. The virus may remain dormant for extended periods. Periodic reactivation of the virus can occur, leading to recurrent episodes of HSK. Factors triggering reactivation include stress, illness, immunosuppression, or trauma. Recurrent episodes can manifest in different clinical patterns, ranging from mild epithelial involvement to more severe stromal or endothelial disease. The severity and frequency of recurrences vary among individuals. Severe cases of HSK, especially those involving the stroma and leading to scarring, can result in vision impairment or even blindness in extreme cases. The cornea's clarity is crucial for good vision, and scarring can compromise this, potentially leading to visual impairment. The management of HSK involves not only treating acute episodes but also implementing long-term strategies to prevent recurrences and attempt repairs of corneal nerve endings via neurotization. Antiviral medications, such as oral Acyclovir or topical Ganciclovir, may be prescribed for prophylaxis. The immune response to the virus can contribute to corneal damage. Inflammation, caused by the body's attempt to control the infection, may inadvertently harm the corneal tissues. Clinicians should be informed about triggers and advised on measures to minimize the risk of reactivation. In summary, the recurrent nature of HSK underscores the importance of both acute and long-term management strategies to preserve corneal health and maintain optimal visual function.

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Section: Immune Responses In Herpes Simplex Keratitis: Implications F...mentioning

confidence: 99%