Novel chalcone-based aromatic polyamides: synthesis, characterization, and properties

Nechifor, M

doi:10.1080/15685551.2015.1136524

Cited by 11 publications

(7 citation statements)

References 25 publications

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“…GC-MS analysis also revealed the presence of specific constituents for PDMS devices fabricated from SU-8 molds: chalcone compounds, 2-chloro-ethanesulfonyl chloride and 4-methoxybenzyl alcohol. Chalcones are very reactive upon UV irradiation and are commonly used in the formulation of photoresists such as SU-8 27,28 . Despite their anti-inflammatory, anti-oxidant, anti-nociceptive, anti-parasites, and anti-proliferative pharmaceutical effects, chalcones have also been found to have a myotoxic effect in zebrafish 29 , and to stimulate apoptosis in human colorectal carcinoma cells 30 .…”

Section: Resultsmentioning

confidence: 99%

3D printed mold leachates in PDMS microfluidic devices

Ferraz

Nagashima

Venzac

et al. 2020

Sci Rep

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The introduction of poly(dimethylsiloxane) (PDMS) and soft lithography in the 90's has revolutionized the field of microfluidics by almost eliminating the need for a clean-room environment for device fabrication. More recently, 3D printing has been introduced to fabricate molds for soft lithography, the only step for which a clean-room environment is still often necessary, to further support the rapid prototyping of PDMS microfluidic devices. However, toxicity of most of the commercial 3D printing resins has been established, and little is known regarding the potential for 3D printed molds to leak components into the PDMS that would, in turn, hamper cells and/or tissues cultured in the devices. In the present study, we investigated if 3D printed molds produced by stereolithography can leach components into PDMS, and compared 3D printed molds to their more conventional SU-8 counterparts. Different leachates were detected in aqueous solutions incubated in the resulting PDMS devices prepared from widely used PDMS pre-polymer:curing agent ratios (10:1, 15:1 and 20:1), and these leachates were identified as originating from resins and catalyst substances. Next, we explored the possibility to culture cells and tissues in these PDMS devices produced from 3D printed molds and after proper device washing and conditioning. Importantly, we demonstrated that the resulting PDMS devices supported physiological cultures of HeLa cells and ovarian tissues in vitro, with superior outcomes than static conventional cultures. Organ-on-a-chip models, by providing an in vivo-like environment, show great potential to advance our understanding of tissue development, physiology, and pathology 1. However, the spread of these highly promising platforms out of specialized microfluidic laboratories is hindered by essential technical challenges. The fabrication of these devices requires having access to dedicated infrastructure such as clean-room facilities with specialized equipment, which is absent in most biological laboratories 1. Novel fabrication processes have been developed to support the rapid prototyping of microfluidic devices, including soft-lithography using PDMS (polydimethylsiloxane) 2,3. PDMS is a transparent, flexible, gas-permeable, fairly inexpensive and rapidly prototyped elastomeric material, which has now become ubiquitous in the field of microfluidics 2,3. PDMS devices are commonly fabricated using molds based on SU-8 (Microchem Corp.), which is a negative epoxy-based photoresist 4. However, the fabrication of SU-8 molds uses lithography and includes multiple steps, it altogether takes several hours per fabrication cycle, and still requires dedicated training and access to a clean-room facility 5,6. As a new revolution in the field of microfluidics, 3D printing has more recently been introduced 7. Initially the use of 3D printing was limited by the price of the printers, their low resolution, the roughness of the 3D printed structures, and the toxicity of the resins 8-10. Photopolymerization-based techniques, such as dig...

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Section: Resultsmentioning

confidence: 99%

3D printed mold leachates in PDMS microfluidic devices

Ferraz

Nagashima

Venzac

et al. 2020

Sci Rep

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“…Furthermore, the time-dependent density functional theory at the MPW1PW91/6-31G* level and the theory on the relaxed geometries at the UB3LYP/6-31G* level was used to simulate the UV-visible absorption spectra and calculate the triplet state energy levels of the two series of dyes [34][35].…”

Section: Molecular Modelingmentioning

confidence: 99%

Photopolymerization and 3D/4D applications using newly developed dyes: Search around the natural chalcone scaffold in photoinitiating systems

et al. 2021

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Two series of 18 new dyes selected from in silico molecular design (i.e.through molecular orbital calculations) were synthesized and used in conjunction with an amine (i.e. ethyl l,4-(dimethylamino)benzoate, EDB) and an iodonium salt (bis(4tert-butylphenyl)iodonium hexafluorophosphate, Iod) as photoinitiating systems (PISs) capable of initiating the free radical polymerization of polyethylene glycol (600) diacrylate (PEG-diacrylate) and the cationic polymerization of 3,4epoxycyclohexylmethyl-3,4-epoxycyclohexanecarboxylate (EPOX) via an oxidationreduction reaction mechanism. Even though most of these dyes exhibit excellent light absorption properties below 380 nm, the photopolymerization efficiency of acrylates carried out under LED@405 nm are much better than that reached with a LED@375 nm both in thin films and thick films. Furthermore, all of them can also boost the cationic polymerization of EPOX upon LED irradiation at 405 nm, in the presence of an iodonium salt and an amine. More interestingly, stereoscopic 3D patterns were successfully fabricated by the laser writing technique which demonstrated reversible swelling properties and reversible shape-memory effects induced via swelling and dehydration for the access to 4D printing.

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“…Chalcone is a class of dyes that can be found in many natural plants and exhibit different light absorption properties and colors depending on the substituents as well as their positions onto the chalcone backbone [19][20][21][22]. In our previous research, more than 50 mono-chalcone derivatives have been studied as photoinitiators for their excellent light absorption properties at the near UV and visible range [23][24][25].…”

Section: Introductionmentioning

confidence: 99%