Novel cell-based strategies for immunomodulation in vascularized composite allotransplantation
Maria Siemionow,
Yalcin Kulahci,
Fatih Zor
Abstract:Purpose of review
Vascularized composite allotransplantation (VCA) has become a clinical reality in the past two decades. However, its routine clinical applications are limited by the risk of acute rejection, and the side effects of the lifelong immunosuppression. Therefore, there is a need for new protocols to induce tolerance and extend VCA survival. Cell- based therapies have emerged as an attractive strategy for tolerance induction in VCA. This manuscript reviews the current strategies and appl… Show more
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