Novel Cell Adhesion Molecules: Roles in Implantation?

MacCalman, Colin D.; Omigbodun, Akinyinka; Tian, X. Cindy; Fortune, J.E.; Furth, Emma E.; Coutifaris, Christos; StraussIII, Jerome F.

doi:10.1007/978-3-662-10323-4_7

Cited by 5 publications

(8 citation statements)

References 46 publications

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“…This cad-11 mRNA transcript has been previously detected in RNA extracts prepared from a range of human tissues, including endometrium, placenta, and ovary (5,6,18). This cad-11 mRNA transcript has been previously detected in RNA extracts prepared from a range of human tissues, including endometrium, placenta, and ovary (5,6,18).…”

Section: Discussionmentioning

confidence: 83%

17β-Estradiol Potentiates the Stimulatory Effects of Progesterone on Cadherin-11 Expression in Cultured Human Endometrial Stromal Cells*

1998

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Cadherin-11 (cad-11) is a novel member of the cadherin gene superfamily of calcium-dependent cell adhesion molecules. To date, the factors capable of regulating this cell adhesion molecule remain poorly characterized. We have recently determined that cad-11 expression in the human endometrium is tightly regulated during the menstrual cycle. The spatiotemporal expression of cad-11 in the stromal cells of the human endometrium during the menstrual cycle suggests that gonadal steroids regulate the expression of this endometrial cell adhesion molecule. In view of these observations, we have examined the ability of progestins, estrogens, and androgens, alone or in combination, to regulate cad-11 expression in isolated human endometrial stromal cells using Northern and Western blot analyses. In these studies, we have determined that progesterone, but not 17beta-estradiol or dihydrotestosterone, is capable of regulating cad-11 messenger RNA and protein expression levels in isolated endometrial stromal cells. In addition, 17beta-estradiol, but not dihydrotestosterone, was capable of potentiating the stimulatory effects of progesterone in a dose-dependent manner. Taken together, these observations suggest that both 17beta-estradiol and progesterone are required for maximal cad-11 expression in human endometrial stromal cells in vitro.

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Section: Discussionmentioning

confidence: 83%

17β-Estradiol Potentiates the Stimulatory Effects of Progesterone on Cadherin-11 Expression in Cultured Human Endometrial Stromal Cells*

1998

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“…In addition, the spatiotemporal expression of another atypical cadherin subtype, known as cadherin-11 (cad-11) or OB-cadherin, has been associated with bone formation (Okazaki et al, 1994) and the development of the central nervous system in the rodent embryo (Kimura et al, 1995;Hoffmann and Balling, 1995). Finally, cad-11 expression is tightly regulated during the terminal differentiation of trophoblast cells isolated from the human term placenta, suggesting that this CAM may be involved in the formation and organization of this tissue (MacCalman et al, 1996(MacCalman et al, , 1997.…”

Section: Introductionmentioning

confidence: 99%

“…We have recently determined that two atypical cadherins, cad-11 and cad-6, are present in the human endometrium (MacCalman et al, 1996(MacCalman et al, , 1997. Cad-11 is expressed in the glandular and surface epithelium of the human endometrium at all stages of the menstrual cycle but is only detected in the stroma during the late luteal phase (MacCalman et al, 1996(MacCalman et al, , 1997. Cad-6 was detected in endometrial stromal cells isolated during the follicular phase of the menstrual cycle using the reverse transcriptase-polymerase chain reaction (RT-PCR;MacCalman et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

Regulated expression of cadherin-6 and cadherin-11 in the glandular epithelial and stromal cells of the human endometrium

et al. 1998

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The cadherins are key morphoregulators. A switch in the cadherin subtype(s) expressed by a population of cells has been associated with the differentiation and formation of tissues during embryonic development. To date, the role(s) of the cadherins in the highly regulated remodeling processes which occur in the human endometrium in preparation for the implanting embryo remain poorly characterized. Here we report that two atypical cadherins, known as cadherin‐6 and cadherin‐11, are spatiotemporally expressed in the human endometrium during the menstrual cycle. Cadherin‐6 levels are high in both the glandular epithelium and stroma of the endometrium during the follicular phase and decline as the cycle enters the luteal phase. The down‐regulation of cadherin‐6 in the glandular epithelium during the luteal phase does not effect the levels of cadherin‐11 in this cell type. In contrast, the loss of cadherin‐6 expression in endometrial stroma cells is concomitant with an increase in the levels of cadherin‐11. Collectively, these observations suggest that multiple factors regulate the expression of these two endometrial cadherins. As a first step in identifying these factors, we examined the effects of progesterone on cadherin‐6 and cadherin‐11 expression in isolated endometrial stromal cells. Progesterone was capable of differentially regulating the expression of these two stromal cell adhesion molecules. These findings lend further support to our hypothesis that steroids are key regulators of cadherin expression in mammalian tissues. Dev. Dyn. 1998;211:238‐247. © 1998 Wiley‐Liss, Inc.

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“…Cadherin-11 (cad-11) is a novel cadherin subtype that is spatiotemporally expressed in the human endometrium and placenta (MacCalman et al, 1996(MacCalman et al, , 1997 (Graham et al, 1992; Graham, 1997 …”

Section: Introductionmentioning

confidence: 99%

Regulated expression of cadherin-11 in human extravillous cytotrophoblasts undergoing aggregation and fusion in response to transforming growth factor 1

et al. 1998

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Novel Cell Adhesion Molecules: Roles in Implantation?

Cited by 5 publications

References 46 publications

17β-Estradiol Potentiates the Stimulatory Effects of Progesterone on Cadherin-11 Expression in Cultured Human Endometrial Stromal Cells*

17β-Estradiol Potentiates the Stimulatory Effects of Progesterone on Cadherin-11 Expression in Cultured Human Endometrial Stromal Cells*

Regulated expression of cadherin-6 and cadherin-11 in the glandular epithelial and stromal cells of the human endometrium

Regulated expression of cadherin-11 in human extravillous cytotrophoblasts undergoing aggregation and fusion in response to transforming growth factor 1

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