2015
DOI: 10.1016/j.ajpath.2015.04.029
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Novel CCR3 Antagonists Are Effective Mono- and Combination Inhibitors of Choroidal Neovascular Growth and Vascular Permeability

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Cited by 28 publications
(44 citation statements)
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References 32 publications
(37 reference statements)
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“…Conversely, JR5558 mice may harbor a mutation of Rd8, a retinal degeneration gene (132); therefore, interpretation of retinal neuronal pathologies in aged JR5558 mice requires some caution. Nevertheless, this new model provides a useful tool for the study of RAP and AMD, as well as for evaluating potential therapeutics for both diseases, such as IL-18 immunotherapy and C-C chemokine receptor type 3 antagonists (130)(131)(132)(133)(134)(135).…”
Section: Jr5558 Micementioning
confidence: 99%
“…Conversely, JR5558 mice may harbor a mutation of Rd8, a retinal degeneration gene (132); therefore, interpretation of retinal neuronal pathologies in aged JR5558 mice requires some caution. Nevertheless, this new model provides a useful tool for the study of RAP and AMD, as well as for evaluating potential therapeutics for both diseases, such as IL-18 immunotherapy and C-C chemokine receptor type 3 antagonists (130)(131)(132)(133)(134)(135).…”
Section: Jr5558 Micementioning
confidence: 99%
“…Choroidal neovascularisation (CNV), a common vision-threatening complication (16), accounts for 90% of cases of severe vision loss in patients with advanced age-related macular degeneration (17)(18)(19). Its pathogenesis involves a disruption of the homeostasis between the retinal pigment epithelium and Bruch's membrane (20).…”
Section: Choroidal Neovascularizationmentioning
confidence: 99%
“…Although the CCR3-eotaxin pathway has been shown to be involved in ocular pathological angiogenesis in choroidal neovascularization (CNV) [11][12][13][22][23][24] and in corneal angiogenesis [9,10] , to our knowledge, this is the first report to dem- onstrate a role for CCR3-eotaxin pathways in retinal neovascularization. Historically, the CCR3-eotaxin pathway has been known to contribute to eosinophil migration in allergic reactions [25] .…”
Section: Discussionmentioning
confidence: 99%
“…In the experimental mouse model of CNV, systemic anti-CCR3 treatment reduced CNV [12,13] . CCR3 was previously shown to be a target in allergic disease, and various oral CCR3 antagonists have been developed [30][31][32][33] .…”
Section: Discussionmentioning
confidence: 99%
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