Novel carboxymethyl cellulose-halloysite-polyethylene glycol nanocomposite for improved 5-FU delivery

Ghasemizadeh, Haniyeh; Pourmadadi, Mehrab; Yazdian, Fatemeh; Rashedi, Hamid; Navaei‐Nigjeh, Mona; Rahdar, Abbas; Díez‐Pascual, Ana M.

doi:10.1016/j.ijbiomac.2023.123437

Cited by 27 publications

(11 citation statements)

References 54 publications

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“…Furthermore, the result of comparing the effect of the free drug with the encapsulated drug is very important, as it adds an additional advantage to our system compared to other nanocarriers studied by other authors, where this comparison is not made. 20,22,24,43 Consequently, we have developed a highly biocompatible system capable of potentially addressing one of the primary challenges associated with 5-FU�its low bioavailability due to poor absorption. Furthermore, the nanocarrier was engineered to encapsulate the drug without any material loss, ensuring efficient uptake by cancer cells.…”

Section: ■ Conclusionmentioning

confidence: 99%

“…These nanocomposites utilize various materials such as graphitic carbon nitride, gelatin, poly(ethylene glycol), 25 carbon nanotubes, poly(acrylic acid), poly(vinylpyrrolidone) nanoparticles, 26 chitosan/agarose/graphene oxide hydrogel, 27 or nanocomposites based on halloysite nanotubes coated with carboxymethyl cellulose/poly(ethylene glycol) hydrogel. 20 These formulations have demonstrated high encapsulation efficiency. In vitro drug-release studies have shown improved and sustained delivery of 5-FU in acidic environments compared to physiological mediums, confirming the pHsensitivity of the nanocarriers.…”

Section: ■ Introductionmentioning

confidence: 99%

“…That is why it is important to find vehicles that improve bioavailability, allow controlled release, and reduce the adverse effects. In this sense, various carriers have been developed for the encapsulation and release of 5-FU, with the carrier material strongly influencing these two processes. − …”

Section: Introductionmentioning

confidence: 99%

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Electrochemical Characterization of the Encapsulation and Release of 5-Fluorouracil in Nanocarriers Formed from Soy Lecithin Vesicles

Chamorro Cañon,

Luna,

Sabini

et al. 2024

J. Phys. Chem. B

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5-Fluorouracil (5-FU) is an antineoplastic agent known for its low bioavailability and limited cellular penetration, often resulting in adverse effects on healthy cells. Thus, finding vehicles that enhance bioavailability, enable controlled release, and mitigate adverse effects is crucial. The study focuses on encapsulating 5-FU within soy lecithin vesicles (SLVs) and assessing its impact on the carrier's properties and functionality. Results show that incorporating 5-FU does not affect SLVs' size or polydispersity, even postlyophilization. Liberation of 5-FU from SLVs requires system disruption rather than spontaneous release, with an encapsulation efficiency of approximately 43% determined using Square Wave Voltammetry. Cytotoxicity assays on colorectal cancer cells reveal SLV-based delivery's significant efficacy, surpassing free drug solution effects with 45% cell viability after 72 h vs 73% viability. The research addresses 5-FU's limited bioavailability by creating a biocompatible nanocarrier for efficient drug delivery, highlighting SLVs as promising for targeted cancer therapy due to sustained antiproliferative effects and improved cellular uptake. The study underscores the importance of tailored drug delivery systems in enhancing therapeutic outcomes and suggests SLV/5-FU formulations as a potential advancement in cancer treatment strategies.

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Section: ■ Conclusionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

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Electrochemical Characterization of the Encapsulation and Release of 5-Fluorouracil in Nanocarriers Formed from Soy Lecithin Vesicles

Chamorro Cañon,

Luna,

Sabini

et al. 2024

J. Phys. Chem. B

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“…Similarly, pH‐responsive targeting of 5‐fluorouracil was achieved in a study reported by Ghasemizadeh et al A nanocomposite of halloysite nanotubes was prepared loaded with 5‐fluorouracil and further coated with polyethylene glycol and carboxymethyl cellulose. These nanocomposites released 5‐fluorouracil triggered by the acidic pH of breast cancer cell lines (MCF‐7) and significant cytotoxicity was reported compared to administration of free 5‐fluorouracil 60 . Thus, CMC‐based biodegradable nanocarriers are of great interest for developing pH‐responsive delivery systems to target cancer cells usually expressing acidic pH at the tumor microenvironment 61 …”

Section: Classification Of Ph‐responsive Polymersmentioning

confidence: 99%

“…These nanocomposites released 5-fluorouracil triggered by the acidic pH of breast cancer cell lines (MCF-7) and significant cytotoxicity was reported compared to administration of free 5-fluorouracil. 60 Thus, CMC-based biodegradable nanocarriers are of great interest for developing pHresponsive delivery systems to target cancer cells usually expressing acidic pH at the tumor microenvironment. 61…”

Section: Chitosanmentioning

confidence: 99%

pH‐responsive polymers for drug delivery: Trends and opportunities

Singh,

Nayak

2023

Journal of Polymer Science

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Polymer science has applications in biomedical engineering, prosthetics, surgical implants, and prospective pharmaceutical excipients for drug delivery. “Intelligent or Smart Polymers” are created for drug targeting either by derivatization of natural polymers or controlled radical polymerization of electrolytes. Their mode of action is governed by the environmental stimuli viz. temperature, pH, ionic concentration, magnetism, and so on. pH‐responsive polymers, because of their self‐assembling behavior, alter their solubility, conformation, surface activity, and hydrophilicity when exposed to a specific pH. The physiological pH varies from acidic nuclei to alkaline cytoplasm and highly acidic gastric juice to slightly alkaline plasma; thus, various polymers are under study for delivering small molecules, genes, peptides, enzymes, growth factors, and antibodies. The non‐invasive drug delivery routes like oral, ocular, nasal, pulmonary, transdermal, and rectal routes can be explored for targeting recombinant proteins, monoclonal antibodies, and small molecules with particular emphasis on the individual's physiological and pathological state. Further, these polymers can be designed into various architectures like dendrimers, liposomes, micelles, and metallic nanoparticles that can serve as drug reservoirs for sustaining drug release. The challenges in this field are the selection of biocompatible polymers with ease of synthesis and scale‐up, ensuring effective drug‐loading, and stability aspects, producing robust pharmacological data, and timely regulatory approvals. This review exclusively explores the physicochemical characteristics of pH‐responsive polymers, their categorization, various architectural entities, recent studies and patents, and their emerging applications concerning specific diseases.

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