Novel biparametric MRI and targeted biopsy improves risk stratification in men with a clinical suspicion of prostate cancer (IMPROD Trial)

Abstract

1 Technical Efficacy: Stage 5 J. Magn. Reson. Imaging 2017;46:1089-1095.

Radiomic features from pretreatment biparametric MRI predict prostate cancer biochemical recurrence: Preliminary findings

“…The pulse sequences analyzed in the current study included axial turbo spin‐echo (TSE) T 2 WI, axial diffusion‐weighted imaging (DWI) with creation of an apparent diffusion coefficient (ADC) map using vendor‐specific software. Patients in D 2 underwent mpMRI examination performed using a 3T MR scanner and a PPAC . The pulse sequences analyzed in the study included TSE T 2 WI, axial DWI with the creation of an ADC map.…”

Predictive role of PI-RADSv2 and ADC parameters in differentiating Gleason pattern 3 + 4 and 4 + 3 prostate cancer

“…Prostate multiparametric MRI (mpMRI) has emerged as a valuable tool for detection and localization of PCa, for treatment guidance, and for PCa risk stratification [9,10]. Acquisition of apparent diffusion coefficient (ADC) maps, derived from diffusion weighted imaging (DWI), are recommended by the American College of Radiology as part of standardized mpMRI protocol, as it has been shown that adding DWI and ADC maps increases accuracy for PCa detection and localization [11,12].…”

Comparison of quantitative apparent diffusion coefficient parameters with prostate imaging reporting and data system V2 assessment for detection of clinically significant peripheral zone prostate cancer

“…Importantly, the use of high b-values between 1000 and 1500 s/mm2 in DWI is more sensitive to tumor detection, as conspicuity of PC is improved, especially in those adjacent to or invading the anterior fibromuscular stroma [11–13]. Prostate mpMRI has emerged as an excellent method to detect and localize prostate cancer and thus guide treatment selection [14,15]. There have been many studies demonstrating the major role of DWI in detection of Gleason pattern 4 disease, which have led to an interest in investigating the role of MRI in triaging patients before prostate biopsy.…”

“…There have been many studies demonstrating the major role of DWI in detection of Gleason pattern 4 disease, which have led to an interest in investigating the role of MRI in triaging patients before prostate biopsy. Two recent studies, the multi-center prospective PROMIS study and the bi-parametric IMPROD trial have determined that MRI can reduce the biopsy rate by 27% and 24%, respectively [15–16]. …”