Novel biomedical imaging approach for detection of sentinel nodes in an experimental model of gastric cancer

Koyama, T; Tsubota, Akihito; Nariai, Koichi; Mitsunaga, Makoto; Yanaga, Katsuhiko; Takahashi, Hiroshi

doi:10.1002/bjs.5650

Cited by 17 publications

(18 citation statements)

References 24 publications

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“…These molecular biological methods have dramatically improved the sensitivity of SN metastasis in the intraoperative diagnosis but remain incomplete. It is critical to improve the quality of intraoperative diagnosis in SN mapping by developing new techniques [32][33][34]. But basically, allocation bias of metastatic tissue and/or low expression of target mRNA cause false negatives in molecular biological diagnosis.…”

Section: Intraoperative Diagnosis Of Snsmentioning

confidence: 99%

A new stage of sentinel node navigation surgery in early gastric cancer

et al. 2014

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Sentinel node (SN) navigation surgery is expected to realize organ-and function-preserving surgery with SN mapping, and has been applied in operations for breast cancer and melanoma. But there has been no definite evidence for the SN concept in gastric cancer. A prospective multicenter trial to confirm the SN concept for gastric cancer conducted by the Japan Society of Sentinel Node Navigation Surgery reported that the SN detection rate, sensitivity of positive SNs, and accuracy of nodal status are 97.5 % (387/397), 93 % (53/57), and 99 % (383/ 387), respectively. A detailed analysis of the trial suggested that strictly the ''lymphatic basin concept'' rather than the ''SN concept'' was confirmed in early gastric cancer. The Japan Society of Sentinel Node Navigation Surgery started a new trial of function-preserving gastrectomy with lymphatic basin dissection (LBD) for early gastric cancer without metastasis in SNs on the basis of this promising outcome of the trial. It is supposed that LBD guarantees curability in SN navigation surgery for early gastric cancer. Full-thickness resection or endoscopic submucosal dissection in combination with laparoscopic LBD will soon be a new treatment option for early gastric cancer.

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Section: Intraoperative Diagnosis Of Snsmentioning

confidence: 99%

A new stage of sentinel node navigation surgery in early gastric cancer

et al. 2014

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“…39,41,43,50,56 All the studies were designed as prospective trials. Of these, 37 (80%) were prospective descriptive trials, whereas 9 (20%) intentionally planned to include comparative groups.…”

Section: General Resultsmentioning

confidence: 99%

“…Japan (8) Ohdaira et al 35 Prospective Clinical (6) Germany (1) Morita et al 36 Prospective Experimental (3) Ishigami et al 37 Prospective Rino et al 38 Prospective Kitayama et al 39 Gretschel et al 40 Prospective comparison Koyama et al 41 Ishikawa et al 42 Prospective comparison Koyama et al 43 -2008 Japan (3) Yaguchi et al 44 Prospective comparison Clinical (4) Italy (1) Miyashiro et al 45 Prospective comparison Korea (1) Orsenigo et al 46 Prospective Lee et al 47 Prospective comparison Yanagita et al 48 Prospective 2009…”

Section: Identification Of Slnsmentioning

confidence: 98%

Systematic Review of Studies Investigating Sentinel Node Navigation Surgery and Lymphatic Mapping for Gastric Cancer

Can

Yağcı

Çetiner

2013

Journal of Laparoendoscopic & Advanced Surgical Techniques

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Evolutions in minimally invasive surgical techniques and advances in sentinel node navigation surgery (SNNS) have had considerable impact on current insights into surgical treatment of gastric cancer. Extensive data on this method of surgical application have accumulated but have been principally derived from single-institute studies. Isosulfan blue and patent blue violet have been the most frequently used dye tracers in the past; however, indocyanine green has now is increasingly popular. The double-tracer method, where dye and radioisotope tracers are used together, seems to be more effective than any single tracer. Among newly emerging adjunct techniques and promising alternative in particular are infrared ray electronic endoscopy, florescence imaging, nanoparticles, and near-infrared technology. Hematoxylin and eosin (H&E) staining is still the method of choice for the detection of sentinel lymph node (SLN) metastases. Immunohistochemical staining can be used to support H&E findings, but the equipment costs of ultrarapid processing systems are currently slowing down their worldwide spread. We believe minimally invasive function-preserving resection of the stomach, together with lymphatic basin dissection navigated by SLNs, can represent the ideal approach for SNNS to detect clinically node-negative early gastric cancer, although this remains to be elucidated. Patients with cT3 or more advanced disease should still be treated by means of standard D2 dissection.

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“…With the visual advantage of ATX-S10Na (II), SNs would not be missed, and the time required for the surgical procedure may be shortened. In a comparative study using an orthotopic xenograft rat model, there was no significant difference in the detection rates of SNs, the sensitivity, and the number of stained nodes between ATX-S10Na (II) -and enhanced ICG-guided methods (Koyama et al, 2007b). These results suggest that the ATX-S10Na (II)-guided method is comparable to or possibly superior to the enhanced ICG-guided method.…”

Section: Wwwintechopencommentioning

confidence: 86%

“…Therefore, it has substantially less adverse effects (Matsumoto et al, 2003;Mori et al, 2000a;Nakajima et al, 1992;Nakajima et al, 1998). We acknowledge that our studies were conducted in an orthotopic xenograft rat model (Koyama et al, 2007a(Koyama et al, , 2007b, in which the structure and anatomy of the regional lymphatic network may be different from those of human system (Ichikura et al, 2002;Miwa et al, 2003). Alternatively, the rat model may not be comparable to early gastric carcinoma in humans, for which sentinel node navigation surgery is more suitable (Hiratsuka et al, 2001;Isozaki et al, 2004).…”

Section: Little Toxicity In Humanmentioning

confidence: 99%

Novel Biomedical Imaging Approach for Detection of Sentinel Nodes in an Orthotopic Xenograft Rat Model of Human Gastric Carcinoma

Tsubota¹

2011

Management of Gastric Cancer

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Novel biomedical imaging approach for detection of sentinel nodes in an experimental model of gastric cancer

Abstract: These results support the validity of the ATX-S10Na(II)-guided approach in the detection of SNs in gastric cancer in vivo.

Cited by 17 publications

References 24 publications

A new stage of sentinel node navigation surgery in early gastric cancer

A new stage of sentinel node navigation surgery in early gastric cancer

Systematic Review of Studies Investigating Sentinel Node Navigation Surgery and Lymphatic Mapping for Gastric Cancer

Novel Biomedical Imaging Approach for Detection of Sentinel Nodes in an Orthotopic Xenograft Rat Model of Human Gastric Carcinoma

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