Novel Biomarkers of Subclinical Cardiac Dysfunction in the General Population

Shemisa, Kamal; Bhatt, Anish; Cheeran, Daniel; Neeland, Ian J.

doi:10.1007/s11897-017-0342-z

Cited by 20 publications

(27 citation statements)

References 71 publications

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“…22,32 Compared with our hsTnI and BNP results, high proportions (>50%) of men and women were classified as high-risk for CHD on the basis of their HCY level. Whereas hsTnI and BNP are very specific biomarkers for cardiac problems, 7,25,26 plasma HCY levels are increased by a wide range of factors, including certain lifestyle factors, vitamin deficiencies and drugs, 13,25 which may have contributed to this result.…”

Section: Discussionmentioning

confidence: 99%

“…5 Furthermore, the subclinical cardiac dysfunction that precedes HF and other CVD is often undiagnosed because of a lack of screening and testing strategies. 7 The measurement of biomarkers in the general population may help to identify at-risk individuals for timely intervention and prevention before the onset of clinically detectable risk factors or symptomatic CVD. 7,8 To obtain clear local NCD risk data in the general population of Johor, Malaysia, we conducted a community-based project in which members of public were encouraged to undergo blood-based biomarker tests to screen for risk of various NCDs.…”

Section: Introductionmentioning

confidence: 99%

“…7 The measurement of biomarkers in the general population may help to identify at-risk individuals for timely intervention and prevention before the onset of clinically detectable risk factors or symptomatic CVD. 7,8 To obtain clear local NCD risk data in the general population of Johor, Malaysia, we conducted a community-based project in which members of public were encouraged to undergo blood-based biomarker tests to screen for risk of various NCDs. Here, we report the results of the CVD arm of the project, in which high-sensitivity troponin I (hsTnI), B-type natriuretic peptide (BNP) and homocysteine (HCY) levels were measured to assess distribution of the population with previously reported risk thresholds.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Cardiovascular Disease Risk Assessment With High-Sensitivity Cardiac Troponin I and Other Biomarkers: An Observational Cohort Study in Johor, Malaysia

Sickan

et al. 2020

MJPHM

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Although cardiovascular disease (CVD) is a major health challenge in Malaysia, many Malaysians are unaware of their CVD risk. The measurement of biomarkers in the general population may help to identify at-risk individuals before the onset of symptomatic CVD. The aim of this community health screening project was to determine the distribution of high-sensitivity troponin I (hsTnI) and other biomarkers of CVD risk in the general population of Johor, Malaysia. A sampling of self-declared healthy volunteers was conducted during the 2016 Kembara Mahkota community event in Johor. Levels of hsTnI, B-type natriuretic peptide (BNP) and homocysteine (HCY) were analyzed using the ARCHITECT immunoassay and clinical chemistry platforms utilizing fresh venous blood samples. Based on previous data, biomarker levels indicative of high risk were >10 and >12 ng/mL for hsTnI in women and men, respectively, BNP >50 pg/mL in the overall population, and HCY >13.6 µmol/L in women and >16.2 µmol/L in men. A total of 2744 volunteers participated in biomarker testing. Biomarker measurements showed that up to 10% of participants had moderate or high CVD risk based on hsTnI, approximately 2% were above the BNP threshold and >50% of subjects were above the HCY threshold. General population biomarker testing shows distribution of biomarker levels that may be indicative of CVD risk or the presence of disease and suggests that biomarker-guided risk strategies should be more widely implemented to determine the impact they would have on early detection and prevention of disease.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cardiovascular Disease Risk Assessment With High-Sensitivity Cardiac Troponin I and Other Biomarkers: An Observational Cohort Study in Johor, Malaysia

Sickan

et al. 2020

MJPHM

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“…Before patients develop the full-blown picture of HF, they pass into an asymptomatic (subclinical) stage. Patients usually go undiagnosed during this stage due to lack of screening programs [ 8 ]. Subclinical cardiac dysfunction can be detected by decreased left ventricular ejection fraction (LVEF), increased left atrial volume (LAV), and higher left ventricular (LV) mass as measured by ordinary echocardiography [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

The association of diurnal blood glucose variability with subclinical cardiac disease in patients with type 2 diabetes mellitus

Shehab-Eldin¹,

El-Ashmawy²,

Ahmed³

et al. 2020

Journal of the Saudi Heart Association

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Background The relationship between glycemic control and the risk of cardiac disease in patients with Type 2 Diabetes Mellitus (T2DM) is controversial. 1,5-Anhydroglucitol (1,5-AG) is a biomarker of Glucose Variability (GV) and has been associated with clinical cardiovascular disease. However, its association with Subclinical Cardiac Disease (SCD) is unknown. Aim of the work Study the association between GV and SCD. Subjects and methods A cross-sectional study was conducted on 46 asymptomatic patients with T2DM as T2DM individuals group. Another 46 non-diabetic age and sex matched subjects were included as the healthy group. 1,5-AG was measured for all subjects. M-mode echocardiography in parasternal long axis view was used to measure Left Ventricular (LV) end diastolic dimension, LV end systolic dimension, ejection fraction, interventricular septum, LV posterior wall thickness, LV fractional shortening, left atrial dimension and aortic root dimension. Global Longitudinal Strain (GLS) was assessed by speckled tracking echocardiography. Results There were no significant differences between both groups as regarding age, sex, BMI, AST, ALT, and serum creatinine. 1,5-AG was lower in T2DM individuals group. As regarding the echo parameters no significant difference found between both groups regarding left ventricular, left atrial and aortic root dimensions. T2DM individuals group showed a statistically significant higher mitral valve area, apical 2 chambers, apical 4 chambers, apical longitudinal axis and GLS. No correlation found between HbA1c and any echo parameters while 1,5-AG showed a significantly negative correlation with apical 2 chambers, apical 4 chambers, apical longitudinal axis and GLS. ROC curve analysis detected 1,5-AG less than 7.51 ng/ml as the best cut off value with sensitivity of 85.7%, specificity 75% to diagnose patients with T2DM and SCD. Conclusion 1,5-AG might be used as an additional surrogate marker to identify patients with T2DM and SCD.

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“…Certain cyclic myocardial injury markers, including high-sensitivity cardiac troponin (4), natriuretic peptide (5) and cyclic microRNA (miRNA) (6) have garnered a great deal of attention. However, the number of available markers remains limited.…”

Section: Introductionmentioning

confidence: 99%

Plasma‑derived exosomal miR‑183 associates with protein kinase activity and may serve as a novel predictive biomarker of myocardial ischemic injury

et al. 2019

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Myocardial infarction (MI) is primarily caused by ischemic heart or coronary artery disease and is a major cause of mortality worldwide. Thus, it is necessary to establish reliable biochemical markers for the early diagnosis of MI. MicroRNAs (miRNAs or miR) have been demonstrated to circulate in biological fluids and are enclosed in extracellular vesicles, including exosomes. The current study assessed the differential expression of exosomal miRNAs in the plasma of patients with MI and healthy individuals, and the possible mechanism involved. Plasma-derived exosomes were isolated from patients with MI and healthy control individuals, and vesicles with a membrane were observed using transmission electron microscopy. Furthermore, an exosomal miRNA expression profile was compared between patients with MI and healthy individuals using a miRNA microarray. Significantly differentially expressed miRNAs were validated using reverse transcription-quantitative polymerase chain reaction. To the best of our knowledge, the present study was the first to demonstrate that miR-183 was markedly upregulated in patients with MI compared with healthy individuals. In addition, the relative exosomal miR-183 level increased with the degree of myocardial ischemic injury. Additionally, GO and KEGG analyses demonstrated that miR-183 is primarily involved in cell communication, protein kinase activity regulation and adrenergic signaling in cardiomyocytes. Furthermore, a protein-protein interaction network of all the miR-183 target genes was constructed. The results demonstrated that five core genes ( PPP2CB, PPP2CA, PRKCA, PPP2CA, PPP2R5C and PPP2R2A ) in the PPI network were also associated with protein kinase activity regulation and adrenergic signaling in cardiomyocytes. Taken together, these data demonstrate that exosomal miR-183 derived from the serum of patients with MI may be a novel diagnostic biomarker involved in the regulation of protein kinase activity. miR-183 may therefore be further developed for clinical use to benefit patients with coronary artery diseases.

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Novel Biomarkers of Subclinical Cardiac Dysfunction in the General Population

Cited by 20 publications

References 71 publications

Cardiovascular Disease Risk Assessment With High-Sensitivity Cardiac Troponin I and Other Biomarkers: An Observational Cohort Study in Johor, Malaysia

Cardiovascular Disease Risk Assessment With High-Sensitivity Cardiac Troponin I and Other Biomarkers: An Observational Cohort Study in Johor, Malaysia

The association of diurnal blood glucose variability with subclinical cardiac disease in patients with type 2 diabetes mellitus

Plasma‑derived exosomal miR‑183 associates with protein kinase activity and may serve as a novel predictive biomarker of myocardial ischemic injury

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