Novel Biomarkers of Diabetic Kidney Disease

Rico-Fontalvo, Jorge; Aroca-Martínez, Gustavo; Daza-Arnedo, Rodrigo; Cabrales, José; Yánez, Tomás Rodríguez; Cardona-Blanco, María; Montejo-Hernández, Juan; Barrios, Dairo Rodelo; Patiño-Patiño, Jhonny; Rodríguez, Elber Osorio

doi:10.3390/biom13040633

Cited by 14 publications

(9 citation statements)

References 76 publications

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“…Nephrin is another transmembrane protein that is normally released from podocytes, and its higher urinary levels indicate early glomerular damage and podocytopathies [ 37 ]. The urinary levels of KIM-1, nephrin, and NGAL are significantly increased and used as renal damage markers of DN in both T1DM and T2DM [ 38 , 39 , 40 , 41 ].…”

Section: Discussionmentioning

confidence: 99%

Phloretamide Protects against Diabetic Kidney Damage and Dysfunction in Diabetic Rats by Attenuating Hyperglycemia and Hyperlipidemia, Suppressing NF-κβ, and Upregulating Nrf2

Al-Hussan,

Albadr,

Alshammari

et al. 2024

Pharmaceutics

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Potent hypoglycemic and antioxidant effects were recently reported for the apple-derived phenolic compound phloretamide (PLTM). The renoprotective effects of this compound are yet to be shown. This study aimed to examine the potential of PLTM to prevent diabetic nephropathy in streptozotocin-induced diabetic rats and to examine the possible mechanisms of protection. Non-diabetic and STZ-diabetic male rats were treated orally by gavage with either the vehicle or with PTLM (200 mg/kg; twice/week) for 12 weeks. PTLM significantly increased urine volume and prevented glomerular and tubular damage and vacuolization in STZ-diabetic rats. It also increased creatinine excretion and reduced urinary albumin levels and the renal levels of kidney injury molecule-1 (KIM-1), 8-hydroxy-2′-deoxyguanosine (8-OHdG), neutrophil gelatinase-associated lipocalin (NGAL), and nephrin in the diabetic rats. PTLM also prevented an increase in the nuclear levels of NF-κβ, as well as the total levels of tumor necrosis factor-alpha (TNF-α), interleukin 6 (IL-6), caspase-3, and Bax in the kidneys of diabetic rats. These effects were associated with reduced serum levels of triglycerides, cholesterol, and low-density lipoprotein cholesterol. In both the control and diabetic rats, PTLM significantly reduced fasting plasma glucose and enhanced the renal mRNA and cytoplasmic levels of Nrf2, as well as the levels of Bcl2, superoxide dismutase (SOD), and glutathione (GSH). However, PTLM failed to alter the cytoplasmic levels of keap1 in diabetic rats. In conclusion, PTLM prevents renal damage and dysfunction in STZ-diabetic rats through its hypoglycemic and hypolipidemic activities, as well as through its antioxidant potential, which is mediated by activating the Nrf2/antioxidant axis.

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Section: Discussionmentioning

confidence: 99%

Phloretamide Protects against Diabetic Kidney Damage and Dysfunction in Diabetic Rats by Attenuating Hyperglycemia and Hyperlipidemia, Suppressing NF-κβ, and Upregulating Nrf2

Al-Hussan,

Albadr,

Alshammari

et al. 2024

Pharmaceutics

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“…KIM-1 is a type I transmembrane glycoprotein that is expressed in the apical membrane of proximal renal tubule cells [68]. This biomarker is characterized by appearing 12-24 h after the onset of the injury [67], relating to the severity of the infection [69].…”

Section: Cellular Immunoglobulin Mucin Domain 1 (Kim-1)mentioning

confidence: 99%

Acute Kidney Injury Associated with Severe Leptospirosis: Fatal Re-Emerging Disease in Latin America

Osorio-Rodríguez,

Rodelo-Barrios,

Rebolledo-Maldonado

et al. 2024

Kidney and Dialysis

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Leptospirosis is a re-emerging zoonotic disease that has had an unprecedented impact on most health systems in the world. The spectrum of symptoms is variable and usually ranges from asymptomatic cases to severe manifestations involving multiple organ dysfunction accompanied by jaundice, hemorrhage, meningitis, and acute kidney injury that requires the need for intensive care assistance. Although early antibiotic treatment is usually effective, in severe cases, it may require renal replacement therapy, invasive mechanical ventilation, vasoactive support, and invasive hemodynamic monitoring, increasing the risk of death. In Latin America, the real burden of acute kidney injury in this condition is unknown and may be underestimated due to the rapid progression of the disease, similar to other vector zoonoses, and the low coverage of diagnostic tests in primary care, especially in rural regions. Therefore, below, we review the clinical aspects and describe the scientific, clinical, and therapeutic evidence of acute kidney injury attributed to Leptospira spp. and its relevance in patients with severe leptospirosis in Latin America.

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“…KIM-1 is a type I transmembrane glycoprotein that is expressed in the apical membrane of proximal renal tubule cells [54]. This biomarker is characterized by appearing 12-24 hours after the onset of the injury [53], relating to the severity of the infection [55].…”

Section: Cellular Immunoglobulin Mucin Domain 1 (Kim-1)mentioning

confidence: 99%

Acute Kidney Injury Associated with Severe Leptospirosis: Fatal Re-Emerging Disease in Latin-America

Osorio-Rodríguez,

Rodelo-Barrios,

Rebolledo-Maldonado

et al. 2023

Preprint

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Leptospirosis is a re-emerging zoonotic disease that has had an unprecedented impact on most health systems in the world. The spectrum of symptoms is variable and usually ranges from asymptomatic cases to severe manifestations involving multiple organ dysfunction accompanied by jaundice, hemorrhage, meningitis, and acute kidney injury that requires the need for intensive care assistance. Although early antibiotic treatment is usually effective, in severe cases it may require renal replacement therapy, invasive mechanical ventilation, vasoactive support, and invasive hemodynamic monitoring, increasing the risk of death. In Latin America, the real burden of acute kidney injury in this condition is unknown and may be underestimated due to the rapid progression of the disease, similar to other vector zoonoses, and the low coverage of diagnostic tests in primary care, especially in rural regions. Therefore, below, we review the clinical aspects and describe the scientific, clinical, and therapeutic evidence of acute kidney injury attributed to Leptospira spp. and its relevance in patients with severe leptospirosis in Latin America.

show abstract

Novel Biomarkers of Diabetic Kidney Disease

Cited by 14 publications

References 76 publications

Phloretamide Protects against Diabetic Kidney Damage and Dysfunction in Diabetic Rats by Attenuating Hyperglycemia and Hyperlipidemia, Suppressing NF-κβ, and Upregulating Nrf2

Phloretamide Protects against Diabetic Kidney Damage and Dysfunction in Diabetic Rats by Attenuating Hyperglycemia and Hyperlipidemia, Suppressing NF-κβ, and Upregulating Nrf2

Acute Kidney Injury Associated with Severe Leptospirosis: Fatal Re-Emerging Disease in Latin America

Acute Kidney Injury Associated with Severe Leptospirosis: Fatal Re-Emerging Disease in Latin-America

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