Novel biomarkers of cardiovascular disease: Applications in clinical practice

Lyngbakken, Magnus Nakrem; Myhre, Peder L.; Røsjø, Helge; Omland, Torbjørn

doi:10.1080/10408363.2018.1525335

Cited by 112 publications

(83 citation statements)

References 349 publications

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“…To investigate the effects of rSCUBA diving on CVS function and integrity, we have measured the abovementioned biomarkers (NT-proBNP, high-sensitivity (hs)-TnI, ET-1, and VEGF). In addition, we have measured myoglobin (muscle injury biomarker), C-reactive protein (hs-CRP) and Galectin-3 (Gal-3) (inflammation biomarkers), all of which are clinically implemented and approved CVS biomarkers [14].…”

Section: Introductionmentioning

confidence: 99%

Galectin-3 and Cardiovascular Biomarkers Reflect Adaptation Response to Scuba Diving

et al. 2020

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To understand better the adaptation response of the cardiovascular system (CVS) to self-contained underwater breathing apparatus (SCUBA) diving, Galectin-3 (Gal-3) and specific CVS biomarkers were measured in plasma of 16 male recreational divers before and after (30 min, 3 and 6 h) diving (total time of 30 min at 30 m depth) undertaken a after long non-dive period. The one-time SCUBA dive caused a significant increase in Gal-3, N-terminal prohormone of brain natriuretic peptide (NT-proBNP), high-sensitivity troponin-I (hs-TnI), and myoglobin immediately after diving. Whereas Gal-3 and myoglobin dropped down to the basal levels during the recovery period, NT-proBNP and hs-TnI concentration continued to increase. An immediate increase of vascular endothelial growth factor, detected immediately after diving, was followed by a significant decrease and return to the basal level, 3 and 6 h after diving, respectively. After a significant initial decrease, endothelin-1 increased during the recovery period, but did not return to the basal level. The observed changes in these biomarkers reflect comprehensive, but transient adaptation of CVS and muscular system to the specific environmental conditions during the SCUBA dive. Whether the recurrent activation of these adaption mechanisms due to repetitive dives has positive or negative effects on CVS remains to be elucidated.

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Section: Introductionmentioning

confidence: 99%

Galectin-3 and Cardiovascular Biomarkers Reflect Adaptation Response to Scuba Diving

et al. 2020

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“…Biomarkers have become increasingly important tools helping to improve patient care over the past two decades. Numerous biomarkers have been identi ed in the diagnosis, prognosis and risk prediction of cardiovascular disease but few have made their way to clinical practice [11]. The most extensively used cardiovascular biomarkers are the natriuretic peptides in the diagnosis and prognosis of heart failure and cardiac troponins in the diagnosis of acute myocardial infarction.…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of ST2 for MACEs and all-cause mortality in patients with coronary artery disease during a long-term follow up

M¹,

H²,

Duan³

et al. 2020

Preprint

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PurposeST2 has been proved the prognostic value in acute coronary syndrome (ACS), its prognostic value to predict cardiac events in established coronary artery disease (CAD) patients is unknown. The study ought to investigate the prognostic value of ST2 in patients with established coronary artery disease.MethodsA total of 3650 consecutive patients were included in the study. The primary end point was major adverse cardiovascular events (MACEs). The secondary end point was all-cause death. To explore competing risks, cause-specific hazard ratios were obtained using Cox regression models.ResultsDuring a median follow up of 6.4 years, there were 775 patients had the occurrence of MACEs and 275 patients died. Kaplan–Meier survival estimates indicated that the patients with higher level of ST2 (ST2 > 19 ng/ml) had a significantly increased risk of MACEs (log-rank p<0.001)and all-cause death(log-rank p<0.001). After adjustment for potential confounders, multiple COX regression models showed that higher level of ST2 was an independent predictor in developing MACEs(HR 1.31; 95% CI: 1.13–1.52; p<0.001) and all-cause death(HR 1.78; 95% CI: 1.38–2.30; p<0.001). We saw a significant increase of AUC in ROC curve after addition of GDF-15 to a clinical model 0.586 vs 0.619 For MACEs (p<0.001).For long-term all-cause death the increase of AUC 0.766 vs 0.642 (95% CI 0.787–0.846(p<0.001).ConclusionHigher level of ST2 is significantly associated with long-term all-cause death, MACEs and provides incremental prognostic value beyond traditional risks factors.

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“…This supports the physiological importance of cMyBP-C phosphorylation. During ischemia, dephosphorylated cMyBP-C was more prone to proteolysis than phosphorylated cMyBP-C (Sadayappan et al 2005) and recently 29 kDa cMyBP-C fragments released during ischemia were shown to be useful early indicators of myocardial infarction (Govindan et al 2013;Lyngbakken et al 2019). It is difficult to distinguish the functional effects of phosphorylation of cMyBP-C from other adrenergic targets in the sarcomere, prioritising the use of transgenic models to further enhance our knowledge on these effects.…”

Section: Mybp-c Phosphorylationmentioning

confidence: 99%

MyBP-C: one protein to govern them all

Heling

Geeves

Kad

2020

J Muscle Res Cell Motil

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The heart is an extraordinarily versatile pump, finely tuned to respond to a multitude of demands. Given the heart pumps without rest for decades its efficiency is particularly relevant. Although many proteins in the heart are essential for viability, the non-essential components can attract numerous mutations which can cause disease, possibly through alterations in pumping efficiency. Of these, myosin binding protein C is strongly over-represented with ~ 40% of all known mutations in hypertrophic cardiomyopathy. Therefore, a complete understanding of its molecular function in the cardiac sarcomere is warranted. In this review, we revisit contemporary and classical literature to clarify both the current standing of this fast-moving field and frame future unresolved questions. To date, much effort has been directed at understanding MyBP-C function on either thick or thin filaments. Here we aim to focus questions on how MyBP-C functions at a molecular level in the context of both the thick and thin filaments together. A concept that emerges is MyBP-C acts to govern interactions on two levels; controlling myosin access to the thin filament by sequestration on the thick filament, and controlling the activation state and access of myosin to its binding sites on the thin filament. Such affects are achieved through directed interactions mediated by phosphorylation (of MyBP-C and other sarcomeric components) and calcium.

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Novel biomarkers of cardiovascular disease: Applications in clinical practice

Cited by 112 publications

References 349 publications

Galectin-3 and Cardiovascular Biomarkers Reflect Adaptation Response to Scuba Diving

Galectin-3 and Cardiovascular Biomarkers Reflect Adaptation Response to Scuba Diving

Prognostic value of ST2 for MACEs and all-cause mortality in patients with coronary artery disease during a long-term follow up

MyBP-C: one protein to govern them all

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