Novel biomarkers in the prognosis of patients with atherosclerotic coronary artery disease

miR-19a-3p affected ox-LDL-induced SDC-1/TGF-β1/Smad3 pathway in atherosclerosis

“…Biomarkers have multiple clinical applications at multiple stages of diagnosis and treatment (30). Increased expression of SDC-1 and prevention of increased inflammation was observed in myocardial infarction (30). Our study proved that significant fibrous necrosis and calcification appeared in vulnerable plaque tissues of patients with coronary atherosclerosis, which was accompanied by elevated blood SDC-1 levels.…”

“…Animal studies have shown that SDC-1 signaling was weak in the normal aorta and that arterial injury-induced SDC-1 expression at mRNA and protein levels (29). Biomarkers have multiple clinical applications at multiple stages of diagnosis and treatment (30). Increased expression of SDC-1 and prevention of increased inflammation was observed in myocardial infarction (30).…”

Heart failure in erythrodermic psoriasis: a retrospective study of 225 patients

“…Recent studies have shown that FGF23 not only is associated with the development of cardiac complications in patients with CKD but also may be independently associated with cardiac disease (41). Large epidemiological studies have shown a strong associations between FGF23 concentration and the risks of cardiovascular disease, especially heart failure and stroke, and mortality (42,43). Furthermore, these associations were shown to persist after adjustment for renal dysfunction in another study (44).…”

Uncovering the Genetic Link between Acute Myocardial Infarction and Ulcerative Colitis Co-Morbidity through a Systems Biology Approach

“…ICAM-1 in endothelial cells is induced primarily by TNFα or IL-1β, whereas in intestinal epithelial cells, it is induced by IFNγ [86]. Freitas et al [87] have demonstrated that circulating ICAM-1 levels are positively associated with the risk of coronary artery disease and are a potential marker of cardiovascular disease. The ICAM-1 gene polymorphism is closely associated with the development of UC [88].…”