Novel Biomarkers in Heart Failure: New Insight in Pathophysiology and Clinical Perspective

Biasucci, Luigi M.; Maino, Alessandro; Grimaldi, Maria Chiara; Cappannoli, Luigi; Aspromonte, Nadia

doi:10.3390/jcm10132771

Cited by 24 publications

(37 citation statements)

References 98 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The important prognostic role of sST2 has already been established in several previous studies [10,12,27,29,45] and our results just further ascertained that sST2 is an important predictor of mortality, both in-hospital and at 1-month follow-up. Beside the fact that sST2 was significantly associated with short-term adverse outcomes in patients with acute HF enrolled in our study, we can also consider it as a useful tool for patients' follow-up, whether they are presenting stable or decompensated HF.…”

Section: Discussionsupporting

confidence: 87%

A Novel Paradigm Based on ST2 and Its Contribution towards a Multimarker Approach in the Diagnosis and Prognosis of Heart Failure: A Prospective Study during the Pandemic Storm

Miftode

Constantinescu

Cianga

et al. 2021

Life

View full text Add to dashboard Cite

Background: Acute heart failure (HF) represents an increasingly common and challenging presentation in the emergency room, also inducing a great socio-economic burden. Extensive research was conducted toward finding an ideal biomarker of acute HF, both in terms of sensitivity and specificity, but today practicians’ interest has shifted towards a more realistic multimarker approach. Natriuretic peptides (NPs) currently represent the gold standard for diagnosing HF in routine clinical practice, but novel molecules, such as sST2, emerge as potentially useful biomarkers, providing additional diagnostic and prognostic value. Methods: We conducted a prospective, single-center study that included 120 patients with acute HF and 53 controls with chronic HF. Of these, 13 patients (eight with acute HF, five from the control group) associated the coronavirus-19 disease (COVID-19). The diagnosis of HF was confirmed by a complete clinical, biological and echocardiographic approach. Results: The serum levels of all studied biomarkers (sST2, NT-proBNP, cardiac troponin) were significantly higher in the group with acute HF. By area under the curve (AUC) analysis, we noticed that NT-proBNP (AUC: 0.976) still had the best diagnostic performance, closely followed by sST2 (AUC: 0.889). However, sST2 was a significantly better predictor of fatal events, showing positive correlations for both in-hospital and at 1-month mortality rates. Moreover, sST2 was also associated with other markers of poor prognosis, such as the use of inotropes or high lactate levels, but not with left ventricle ejection fraction, age, body mass index or mean arterial pressure. sST2 levels were higher in patients with a positive history of COVID-19 as compared with non-COVID-19 patients, but the differences were statistically significant only within the control group. Bivariate regression showed a positive and linear relationship between NT-proBNP and sST2 (r(120) = 0.20, p < 0.002). Conclusions: we consider that sST2 has certain qualities worth integrating in a future multimarker test kit alongside traditional biomarkers, as it provides similar diagnostic value as NT-proBNP, but is emerging as a more valuable prognostic factor, with a better predictive value of fatal events in patients with acute HF.

show abstract

Section: Discussionsupporting

confidence: 87%

A Novel Paradigm Based on ST2 and Its Contribution towards a Multimarker Approach in the Diagnosis and Prognosis of Heart Failure: A Prospective Study during the Pandemic Storm

Miftode

Constantinescu

Cianga

et al. 2021

Life

View full text Add to dashboard Cite

show abstract

“…Increasing evidence exists to support the role of the heightened inflammatory milieu present in DM with progression of diastolic dysfunction. DM is associated with increased concentration of serum inflammatory markers such as C-reactive protein (CRP), soluble suppression of tumorgenesis-2 (sST2), galectin-3, C-terminal propeptide of procollagen type I (PICP), N-terminal propeptide of procollagen type III (PIIINP), matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix proteinase-1 (TIMP-1) [ 24 ]. It has been shown that patients with HFpEF and DM have higher levels of (PIIINP), galectin-3 (Gal-3), and TIMP-124.…”

Section: Reviewmentioning

confidence: 99%

Role of Diabetes Mellitus in Heart Failure With Preserved Ejection Fraction: A Review Article

Mgbemena¹,

Zhang²,

Velarde³

2021

Cureus

View full text Add to dashboard Cite

The pathophysiology of heart failure with preserved ejection fraction (HFpEF) is complex and poorly understood. There is a high prevalence of Diabetes Mellitus (DM) in patients with HFpEF, and the presence of DM has been shown to increase mortality of patients with HFpEF by 30%-50% even after adjustment for age, gender, hospital factors, and other patient characteristics. Since the prevalence of both entities is increasing worldwide, there is a need to explore their intricate relationship in order to elucidate potential management strategies to reduce the morbidity and mortality associated with this duo. In this review article, we explore the role of DM in the pathophysiology of HFpEF, ethnic and gender differences, and some therapeutic strategies in the management of patients with HFpEF and DM.

show abstract

“…The same authors also found that the evaluated athletes had similar sST2 concentrations as patients with chronic or even acute heart failure at the start line and after the marathon, respectively [ 86 , 88 ]. sST2 is a proven predictor for mortality and poor outcome in HF [ 89 , 90 , 91 ], and therefore it is controversial that apparently healthy athletes express such high values of sST2. A reasonable explanatory hypothesis is that elevated sST2 concentrations in athletes may be induced by regular exposure to increased cardiac strain during exercise, as this may trigger the cardiac myocytes to release sST2 in circulation.…”

Section: The Soluble Tumor Necrosis Factor-like Weak Inducer Of Apoptosis Soluble Cluster Differentiation 163 and Sst2: Promising Perspecmentioning

confidence: 99%

Beyond the Finish Line: The Impact and Dynamics of Biomarkers in Physical Exercise—A Narrative Review

Costache

Miftode

et al. 2021

JCM

View full text Add to dashboard Cite

The research of biomarkers continues to emerge as a developing academic field which is attracting substantial interest. The study of biomarkers proves to be useful in developing and implementing new screening methods for a wide variety of diseases including in the sports area, whether for leisure activities or professional sports. Novel research has brought into question the immune system and the limitations it may impose on sports practicing. As the well-being of athletes is a priority, the state of their immune function offers valuable information regarding their health status and their ability to continue training. The assessment of various biomarkers may contribute to a more accurate risk stratification and subsequent prevention of some invalidating or even fatal pathologies such as the sudden cardiac death. Therefore, we have reviewed several studies that included sports-related pathology or specific morphofunctional alterations for which some immune biomarkers may represent an expression of the underlying mechanism. These include the defensins, immunoglobulin A (IgA), interleukin-6 (IL-6), the tumoral necrosis factor α (TNF-α), and the white blood cells (WBC) count. Similarly, also of significant interest are various endocrine biomarkers, such as cortisol and testosterone, as well as anabolic or catabolic markers, respectively. Literature data highlight that these values are greatly influenced not only by the duration, but also by the intensity of the physical exercise; moderate training sessions actually enhance the immune function of the body, while a significant increase in both duration and intensity of sports activity acts as a deleterious factor. Therefore, in this paper we aim to highlight the importance of biomarkers’ evaluation in connection with sports activities and a subsequent more adequate approach towards personalized training regimens.

show abstract

Novel Biomarkers in Heart Failure: New Insight in Pathophysiology and Clinical Perspective

Cited by 24 publications

References 98 publications

A Novel Paradigm Based on ST2 and Its Contribution towards a Multimarker Approach in the Diagnosis and Prognosis of Heart Failure: A Prospective Study during the Pandemic Storm

A Novel Paradigm Based on ST2 and Its Contribution towards a Multimarker Approach in the Diagnosis and Prognosis of Heart Failure: A Prospective Study during the Pandemic Storm

Role of Diabetes Mellitus in Heart Failure With Preserved Ejection Fraction: A Review Article

Beyond the Finish Line: The Impact and Dynamics of Biomarkers in Physical Exercise—A Narrative Review

Contact Info

Product

Resources

About