Novel Biodegradable Star-Shaped Polylactide Scaffolds for Bone Regeneration Fabricated By Two-Photon Polymerization

Abstract

The SSL scaffolds provide a beneficial microenvironment for the osteogenic MSCs' differentiation in vitro and support de novo bone formation in vivo.

Enhancement of Healing of Long Tubular Bone Defects in Rabbits Using a Mixture of Atelocollagen Gel and Bone Marrow Aspirate Concentrate

“…Scaffolds usually provide an environment for cell differentiation and survival. In bone tissue engineering, many scaffolds, such as collagen, ceramic, hydroxyapatite scaffolds, and biodegradable synthetic scaffolds including polymer scaffolds, have been developed for inducing bone regeneration [Salinas et al, 2013;Lovati et al, 2016;Timashev et al, 2016;Ye et al, 2016]. As mentioned above, atelocollagen not only acts as a scaffold, but it also promotes osteoblast differentiation and type I collagen production [Kagawa et al, 2012].…”

Polylactide-Based Biodegradable Scaffolds Fabricated by Two-Photon Polymerization for Neurotransplantation

“…Twostaged synthetic strategy of fabricating tetrafunctional polylactides has been presented in the work [9]. A derivative with 760 Da molecular mass of one arm (or 10.5 lactide links) was chosen for fabricating 3D structures.…”

“…The developed strategy of the synthesis of four functional polylactides allowed us to perform the reaction in two stages and to achieve a high percent of the target product yield (>90%) and narrow molecular mass distribution (M w /M n <1.2) [9]. The structure and purity of the synthesized polymer were verified by NMR spectroscopy.…”

“…Degradation of such scaffolds during the culture in vitro or in vivo, and regulation of the rates of new tissue formation relative to the rate of synthetic implant bioresorption is another important topic of implant research [8]. The possibility of gradual material degradation in the process of the scaffold use in vitro allows the process of tissue growth (regeneration) to run [9], whereas in case of the application of biologically stable materials, it may remain in the organism and initiate inflammatory reactions [10,11]. It has been previously shown by us, that 2PP method can be used to fabricate hybrid [12] and hydrogel [13] structures, on which dissociated neuronal cells, obtained from mouse hippocampus, grow.…”

Glycolide/L-Lactide Copolymer (PGLA) Fibers Formed by Wet Spinning from Solution and Modified with Ceramic Nanoadditives

“…Ficek et al in [19] demonstrated the positive results in the treatment of bone cysts using PLA. Timashev et al [20] analyzed the 3D biodegradable scaffold for bone tissue regeneration. Furthermore, the materials made of the lactic acid copolymers have been used as membranes for the GBR (guide bone regeneration), screws and pins to treat defects in bone [21][22][23].In proposed solution, the biodegradable polymer constitutes a scaffold for new osteoblasts cell.…”