Novel Biodegradable Shape‐Memory Elastomers with Drug‐Releasing Capabilities

Serrano, María Concepción; Carbajal, Luis; Ameer, Guillermo A.

doi:10.1002/adma.201004566

Cited by 142 publications

(118 citation statements)

References 27 publications

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“…On the other hand, a few new shape memory phenomena have been discovered [31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47], which not only enhance the flexibility of the current shape memory technology, but also add in new dimensions for extended versatility and adoptability. Consequently, a number of novel concepts have been proposed for a range of engineering applications [45,[48][49][50][51][52][53][54], in particular in the field of biomedical engineering as of the last couple of years [24,43,[55][56][57][58][59][60][61][62][63][64][65][66][67][68][69][70].…”

Section: Figurementioning

confidence: 99%

Mechanisms of the Shape Memory Effect in Polymeric Materials

et al. 2013

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Abstract:This review paper summarizes the recent research progress in the underlying mechanisms behind the shape memory effect (SME) and some newly discovered shape memory phenomena in polymeric materials. It is revealed that most polymeric materials, if not all, intrinsically have the thermo/chemo-responsive SME. It is demonstrated that a good understanding of the fundamentals behind various types of shape memory phenomena in polymeric materials is not only useful in design/synthesis of new polymeric shape memory materials (SMMs) with tailored performance, but also helpful in optimization of the existing ones, and thus remarkably widens the application field of polymeric SMMs.

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Section: Figurementioning

confidence: 99%

Mechanisms of the Shape Memory Effect in Polymeric Materials

et al. 2013

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“…This means polydiolcitrate elastomers could benefit from smart biodegradable materials for tissue engineering applications [103].…”

Section: Smart Drug Delivery Systemmentioning

confidence: 99%

Smart Delivery Systems with Shape Memory and Self-Folding Polymers

Erkeçoğlu¹,

Sezer²,

Bucak³

2016

Smart Drug Delivery System

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New generation delivery systems involve smart materials such as shape memory and self-folding polymers. Shape memory polymers revert back to their original shape above their glass transition temperatures where this temperature change can be induced conventionally, photolytically, with a lazer or magnetically depending on the composition of the material. This ability to assume original shape upon a trigger can be used in delivering drugs, DNA or cells. Self folding polymers are a new class of materials which may be composed of multilayers with different thermal expansion coefficients or with hinges that allow folding upon being triggered. These new materials allow various architectural designs of smart delivery vehicles predominantly for DNA and cells. The aim of this chapter is given shape and folding polymers and their usage for drug delivery systems.

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“…27 More recently, they were produced as shape-memory thermoresponsive polymers, 28 achieved by incorporating a more hydrophobic diol (1,12-dodecanediol, DD) and increasing the mol ratio of hydroxyl to carboxyl groups in the reaction mixture. The obtained networks include covalent netpoints responsible for the permanent shape and hydrophobic microdomains (either pre-polymer or DD-rich domains), physically cross-linked by intermolecular hydrophobic interactions, as switch structures to fix the temporary shape.…”

Section: Synthesis Of Pddc-hd Pre-polymermentioning

confidence: 99%

“…The synthesis of the hydroxyl-dominant poly(1,12-dodecanediol-co-citrate) pre-polymer (PDDC-HD prepolymer) was carried out according to a previously reported protocol. 28 Briefly, citric acid and DD (molar ratio 4:3 of hydroxyl to carboxyl groups) were melted at 165 • C for 10 min, in a round bottom glass flask. Subsequently, the temperature was decreased to 140 • C and the condensation reaction maintained at that temperature for 1 h. …”

Section: Synthesis Of Pddc-hd Pre-polymermentioning

confidence: 99%

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Shape-memory effect for self-healing and biodegradable photonic systems

Espinha

Serrano

Blanco

et al. 2014

Photonic Crystal Materials and Devices XI

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Photonic systems with the capability to respond to different stimuli are more and more desirable for achieving multifunctionality and higher levels of performance. They demand materials with responsivity that may eventually be used for integrating sensing and actuating functions, a feature highly pursued in technological applications. A notable property which is being gradually incorporated in this kind of multifunctional materials is the shape memory effect (SME). In this work, a material system consisting of a two-dimensional photonic crystal (PC) imprinted in the surface of a shape memory polymer (SMP) is reported. It integrates several interesting features such as elasticity, thermoresponsivity and shape memory. The referred PC is composed of a hexagonal lattice of nanobowls, transferred to the SMP surface using replica molding. Good quality and large extensions of PC were achieved. Differential scanning calorimetry studies confirmed a melting transition responsible for the SME in these materials. From the structural point of view, their surfaces were characterized by atomic force and scanning electron microscopies. From the optical point of view, the characterization of the first order Bragg diffraction angle was carried out. A full programmable character of the structures, derived from the SME, was demonstrated. The reported material system presents some interesting additional features. In particular, the SMP selected for replicating the PC belongs to the family of polydiolcitrates, which are known to be biocompatible and biodegradable elastomers. The PC described herein is thus attractive for the development of disposable devices or for temporal usage in biomedicine or biophotonics.

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Novel Biodegradable Shape‐Memory Elastomers with Drug‐Releasing Capabilities

Cited by 142 publications

References 27 publications

Mechanisms of the Shape Memory Effect in Polymeric Materials

Mechanisms of the Shape Memory Effect in Polymeric Materials

Smart Delivery Systems with Shape Memory and Self-Folding Polymers

Shape-memory effect for self-healing and biodegradable photonic systems

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