Novel biodegradable Round Window Disks for inner ear delivery of dexamethasone

Lehner, Eric; Liebau, Arne; Syrowatka, Frank; Knolle, Wolfgang; Plontke, Stefan K.; Mäder, Karsten

doi:10.1016/j.ijpharm.2020.120180

Cited by 17 publications

(9 citation statements)

References 57 publications

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“…The mechanical matrix properties of the PLGA implant in the present study is more flexible with a softer texture, and the release profile provides constant drug levels over time without an initial lag phase [ 17 ]. In previous study, the polymer was mostly degraded after 21 days [ 30 ]. However, swelling, drug release, and polymer degradation are slowed down in vivo due to the small amount of perilymph.…”

Section: Resultsmentioning

confidence: 99%

Microimaging of a novel intracochlear drug delivery device in combination with cochlear implants in the human inner ear

Lehner

Menzel

Gündel

et al. 2021

Drug Deliv. and Transl. Res.

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The effective delivery of drugs to the inner ear is still an unmet medical need. Local controlled drug delivery to this sensory organ is challenging due to its location in the petrous bone, small volume, tight barriers, and high vulnerability. Local intracochlear delivery of drugs would overcome the limitations of intratympanic (extracochlear) and systemic drug application. The requirements for such a delivery system include small size, appropriate flexibility, and biodegradability. We have developed biodegradable PLGA-based implants for controlled intracochlear drug release that can also be used in combination with cochlear implants (CIs), which are implantable neurosensory prosthesis for hearing rehabilitation. The drug carrier system was tested for implantation in the human inner ear in 11 human temporal bones. In five of the temporal bones, CI arrays from different manufacturers were implanted before insertion of the biodegradable PLGA implants. The drug carrier system and CI arrays were implanted into the scala tympani through the round window. Implanted temporal bones were evaluated by ultra-high-resolution computed tomography (µ-CT) to illustrate the position of implanted electrode carriers and the drug carrier system. The µ-CT measurements revealed the feasibility of implanting the PLGA implants into the scala tympani of the human inner ear and co-administration of the biodegradable PLGA implant with a CI array. Graphical abstract

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Section: Resultsmentioning

confidence: 99%

Microimaging of a novel intracochlear drug delivery device in combination with cochlear implants in the human inner ear

Lehner

Menzel

Gündel

et al. 2021

Drug Deliv. and Transl. Res.

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show abstract

“…(Yoon et al, 2015;Zhou et al, 2015). The time required for NPs to enter the body is longer than traditional drugs, but the possible effects of long-term residues of these NPs in animals are still unclear (Wang et al, 2009;Ray et al, 2014;Lehner et al, 2021). Therefore, future studies may need to determine whether the components of NPs will accumulate in the inner ear and the effects of these substances on hair cells.…”

Section: Discussion and Outlook Of Nanomaterials In The Field Of Hearing Lossmentioning

confidence: 99%

“…The drug concentration of IT injection in the inner ear fluid, perilymph, and endolymph was significantly higher than that of oral or non-injection (Jackson and Silverstein, 2002;Buniel et al, 2009). Although IT administration is highly efficient and reduces the toxic and side effects of systemic administration, the concentration of drug reaching the inner ear depends on the dose of drug contacting the RWM circular window membrane of the middle ear, and the difference of RWM permeability will lead to the change of drug retention and elimination rate (Buniel et al, 2009;Lehner et al, 2021), which eventually makes it difficult to formulate a standard for dosing regimen. As a result, it is difficult to achieve precision therapy for hearing loss with traditional medication.…”

Section: Comparison Of Traditional Medicine Treatment and Nanomedicine In Hearing Lossmentioning

confidence: 99%

Promising Applications of Nanoparticles in the Treatment of Hearing Loss

Huang

Xie

et al. 2021

Front. Cell Dev. Biol.

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Hearing loss is one of the most common disabilities affecting both children and adults worldwide. However, traditional treatment of hearing loss has some limitations, particularly in terms of drug delivery system as well as diagnosis of ear imaging. The blood–labyrinth barrier (BLB), the barrier between the vasculature and fluids of the inner ear, restricts entry of most blood-borne compounds into inner ear tissues. Nanoparticles (NPs) have been demonstrated to have high biocompatibility, good degradation, and simple synthesis in the process of diagnosis and treatment, which are promising for medical applications in hearing loss. Although previous studies have shown that NPs have promising applications in the field of inner ear diseases, there is still a gap between biological research and clinical application. In this paper, we aim to summarize developments and challenges of NPs in diagnostics and treatment of hearing loss in recent years. This review may be useful to raise otology researchers’ awareness of effect of NPs on hearing diagnosis and treatment.

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“…However, resorption of the gelfoam does not work well in case of eustachian tube dysfunction or presence of mucosal defect, finally it can frequently induce middle ear fibrosis or adhesions [19]. Previous our experimental study has reported that gelfoam soaked with a corticosteroid prevent the fibrosis in the middle ear [20].. Experimentally and clinically, topical or dexamethasone injection during surgery has been shown to be protective for the inner ear [21,22].…”

Section: Introductionmentioning

confidence: 95%

Middle Ear Packing and External Ear Packing with Fibrin Glue Enhances the Success of Fat Myringoplasty without Hyaluronic Acid Disc

Kim¹,

Jang²

2021

Preprint

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Background: To date, FM using middle ear packing has rarely reported. In this study, we hypothesized that middle ear packing with dexamethasone soaked gelfoam and fibrin glue over the fat graft could promote the success rate of TMP closure regardless of perforation size. Methods: Between January 2005 and July 2020, a total of 209 patients who underwent fat myringoplasty due to chronic TMP at tertiary referral center were encountered and analyzed. The success rate and audiologic outcome was analyzed. Results: The mean successful TM closure rate was 88.0 %. The success rate by different age generation was not significant difference. The size of the perforation grade showed no significant difference. The perforation site by anterior or posterior was not significant. The preoperative mean threshold of AC, BC and ABG were 55.71, 12.98 and 42.73 dB respectively. The postoperative mean threshold of AC, BC and ABG were 23.67, 12.98 and 10.69 dB. The change of preoperative and postoperative hearing showed statistically significant. Conclusion: From our results, the simple trimming of the perforation edge and middle ear packing with external ear canal packing using fibrin glue induced the stable adhesion between the remnant TM and the fat graft.

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Novel biodegradable Round Window Disks for inner ear delivery of dexamethasone

Cited by 17 publications

References 57 publications

Microimaging of a novel intracochlear drug delivery device in combination with cochlear implants in the human inner ear

Microimaging of a novel intracochlear drug delivery device in combination with cochlear implants in the human inner ear

Promising Applications of Nanoparticles in the Treatment of Hearing Loss

Middle Ear Packing and External Ear Packing with Fibrin Glue Enhances the Success of Fat Myringoplasty without Hyaluronic Acid Disc

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